#146 – Michael Mina: Rapid Testing, Viruses, and the Engineering Mindset

[0] The following is a conversation with Michael Minna.

[1] He's a professor at Harvard doing research on infectious disease and immunology.

[2] The most defining characteristic of his approach to science and biology is that of a first principal's thinker and engineer focused not just on defining the problem, but finding the solution.

[3] In that spirit, we talk about cheap, rapid at home testing, which is a solution to COVID -19 that to me has become one of the most obvious, powerful, and doing.

[4] solutions that frankly should have been done months ago and still should be done now as we talk about its accuracy is high for detecting actual contagiousness and hundreds of millions can be manufactured quickly and relatively cheaply in general i love engineering solutions like these even if government bureaucracies often don't it respects science and data it respects our freedom it respects our intelligence and basic common sense quick mention of these sponsor, followed by some thoughts related to the episode.

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[61] And now, here's my conversation with Michael Minna.

[62] What is the most beautiful, mysterious, or surprising idea in the biology of humans or viruses that you've ever come across in your work.

[63] Sorry for the overly philosophical question.

[64] Wow.

[65] Well, that's a great question.

[66] You know, I love the pathogenesis of viruses.

[67] And one of the things that I've worked on a lot is trying to understand how viruses interact with each other.

[68] And so pre all this COVID stuff, I was a I was really, really dedicated to understanding how viruses impact other pathogens.

[69] So how if somebody gets an infection with one thing or a vaccine, does it either benefit or harm you from other things that appear to be unrelated to most people?

[70] And so one system, which is highly detrimental to humans, but what I think is just immensely fascinating, is measles.

[71] And measles gets into a kid's body.

[72] The immune system picks it up and essentially grabs the virus and does exactly what it's supposed to do, which is to take this virus and bring it into the immune system so that the immune system can learn from it, can develop an immune response to it.

[73] But instead, measles plays a trick.

[74] It gets into the immune system, serves almost as a Trojan horse, and instead of getting eaten by these cells, it just takes them over, and it ends up proliferating in the very cells that were supposed to kill it.

[75] And it just distributes throughout the entire body, gets into the bone marrow, kills off children's immune memories.

[76] And so it essentially, what I've found and what my research has found is that this one virus was responsible for as much as half of all of the infectious disease deaths in kids before we, started vaccinated against it, because it was just wiping out children's immune memories to all different pathogens, which is, you know, I think just astounding.

[77] It's just amazing to watch it spread throughout bodies.

[78] We've done the studies in monkeys, and you can watch it just destroy and obliterate people's immune memories in the same way that, you know, some parasite might destroy somebody's brain.

[79] Is that an evolutionary just coincidence, or is there some kind of advantage to this kind of interactivity between pathogens?

[80] I think in that sense, it's just coincidence.

[81] It probably is a good way for measles to, it's a good way for measles to essentially be able to survive long enough to replicate in the body.

[82] It just replicates in the cells that are meant to destroy it.

[83] So it's utilizing armin cells for its own replication, but in so doing, it's destroying the memories of all the other immunological memories.

[84] But there are the viruses.

[85] So a different system is influenza and flu predisposes to severe bacterial infections.

[86] And that, I think, is another coincidence, but I also think that there are that there are some evolutionary benefits that bacteria may hijack and sort of piggyback on viral infections.

[87] Viruses can, they just grow so much quicker than bacteria.

[88] They replicate faster.

[89] And so there's the system with viruses with flu and bacteria where the influenza has these proteins that cleave certain receptors.

[90] And the bacteria want to cleave those same receptors.

[91] I want to cleave the same molecules that gave entrance to those receptors.

[92] So instead the bacteria found out like, hey, you know, we could just piggyback on these viruses.

[93] They'll do it 100 or a thousand times faster than we can.

[94] And so then they'd just piggyback on and they let flu cleave all these silic acids and then the bacteria just glom on and in the wake of it.

[95] So there's all different interactions between pathogens that are just remarkable.

[96] So does this whole system of viruses that interact with each other and so damn good at getting inside our bodies, does that fascinate you or terrify you?

[97] I'm very much a scientist and so it fascinates me much more than it terrifies me. But knowing enough, I know just how well, you know, we get the wrong virus in our population, whether it's through some random mutation or whether it's this same COVID -19 virus.

[98] And it, you know, these things are tricky.

[99] They're able to mutate quickly.

[100] They're able to find new hosts and rearrange in the case of influenza.

[101] So what terrifies me is just how easily this particular pandemic could have been so much worse.

[102] This could have been a virus that is much worse than it is.

[103] You know, same thing with H1N1 back in 2009.

[104] That terrifies me if a virus like that was much more detrimental.

[105] You know, that would be, it could be much more devastating.

[106] Although it's hard to say, you know, the human species were, well, I hesitate to say that we're good at responding to things because there are some aspects that were, this particular virus.

[107] SARS -CoV -2 and COVID -19 has found a sweet spot where it's not quite serious enough on an individual level that humans just don't, we haven't seen much of a useful response by many humans.

[108] A lot of people even think it's a hoax.

[109] And so it's led us down this path of it's not quite serious enough to get everyone to respond immediately and with the most urgency, but it's enough, it's bad enough that, you know, it's caused our economies to shut down and collapse.

[110] And so I think I know enough about virus biology to be terrified for humans that, you know, it can, it just takes one virus, just takes the wrong one to just obliterate us or not obliterate us, but really do much more damage than we've seen.

[111] It's fascinating to think that COVID -19 is a result of a virus evolving together with like Twitter.

[112] Yeah.

[113] Like figuring out how we can sneak past the defenses of the humans.

[114] So it's not bad enough.

[115] And then the misinformation, all that kind of stuff together is operating in such a way that the virus can spread effectively.

[116] I wonder, I mean, obviously a virus is not intelligent, but there's a rhyme and a rhythm to the way this whole evolutionary process works and creates these fascinating things that spread throughout the entire civilization.

[117] Absolutely.

[118] It's, yeah.

[119] I, I, I, I'm completely fascinated by this idea of social media in particular, how it replicates, how it grows, you know, I've been, how it inter, how it actually starts interacting with the biology of the virus, masks, who's going to get vaccinated, politics, like, these seem so external to virus biology, but it's become so intertwined and it's interesting.

[120] and I actually think we could find out that, you know, the virus actually becomes, obviously not intentionally, but, you know, we could find that choosing people choosing not to wear masks, choosing not to counter this virus in a regimented and sort of organized way, effectively gives the virus more opportunity to escape.

[121] We can look at vaccines.

[122] You know, we're about to have one of the most aggressive vaccination programs.

[123] the world has ever seen.

[124] But we are unfortunately doing it right at the peak of viral transmission when millions and millions of people are still getting infected.

[125] And when we do that, that just gives this virus so many more opportunities.

[126] I mean, orders of magnitude more opportunity to mutate around our immune system.

[127] Now, if we were to vaccinate everyone when there's not a lot of virus, then there's just not a lot of virus.

[128] And so there's not going to be as many, you know, I don't know.

[129] even know how many zeros are at the end of however many viral particles there are in the world right now, you know, more than quadrillions.

[130] And so if you assume that at any given time, somebody might have trillions of virus in them and any given individual.

[131] So then, you know, multiply trillions by millions.

[132] And, you know, you get a lot of viruses out there.

[133] And if you start applying pressure, ecological pressure to this virus, that, you know, when it's that abundant, had the opportunity for a virus to sneak around immunity, especially when all the vaccines are identical, essentially.

[134] It takes as one to mutate and then jumps.

[135] Takes one.

[136] Takes one in the whole world, you know, and we have to not forget that this particular virus was one.

[137] It was one opportunity, and it has spread across the globe, and there's no reason that can't happen tomorrow.

[138] I knew, you know, it's scary.

[139] I have a million other questions in this direction.

[140] but I'd love to talk about one of the most exciting aspects of your work, which is testing or rapid testing.

[141] You wrote a great article in time on November 17th.

[142] This is like a month ago about rapid testing titled How We Can Stop the Spread of COVID -19 by Christmas.

[143] Let's jot down the fact that this is a month ago.

[144] So maybe your timeline would be different.

[145] But let's say in a month.

[146] So you've talked about this powerful idea.

[147] for quite a while throughout the COVID -19 pandemic.

[148] How do we stop the spread of COVID -19 in a month?

[149] Well, we use tests like these.

[150] So the only reason the virus continues spreading is because people spread it to each other.

[151] This isn't magic.

[152] Yes.

[153] And so there's a few ways to stop the virus from spreading to each other, and that is you either can vaccinate everyone, and vaccinating everyone is a way to immunologically prevent the virus from growing inside of somebody and therefore spreading.

[154] We don't know yet, actually, if this vaccine, if any of these vaccines are going to prevent onward transmission.

[155] So that may or may not serve to be one opportunity.

[156] Certainly, I think it will decrease transmission.

[157] But the other idea that we have at our disposal now, we had it in May, we had it in June, July, August, September, October, November, and now it's December, we still have it, we still choose not to use it in this country and in much of the world.

[158] And that's rapid testing.

[159] That is giving, it's empowering people to know that they're infected and giving them the opportunity to not spread it to their loved ones and their friends and neighbors and whoever else.

[160] We could have done this.

[161] We still can.

[162] Today we could start.

[163] We have millions of these tests.

[164] These tests are simple papers, test.

[165] They are, inside of this thing is just a little piece of paper.

[166] Now, and I can actually open it up here.

[167] There we go.

[168] So this, this is how we do it right here.

[169] We have this little paper strip test.

[170] This is enough to let you know if you're infectious.

[171] With somewhere around the order of 99 % sensitivity, 99 % specificity, you can know if you have infectious virus in you.

[172] If we can get these out to everyone's homes, build these, make 10 million, 20 million, 30 million of them a day.

[173] You know, we make more bottles of Desani water every day.

[174] We can make these little paper strip tests.

[175] And if we do that, and we get these into people's homes so that they can use them twice a week, then we can know if we're infectious.

[176] You know, is it perfect?

[177] Absolutely not.

[178] But is it near perfect?

[179] Absolutely.

[180] You know, and so if we can say, hey, the transmission of this is, you know, for every 100 people that get infected right now, they go on to infect maybe 130 additional people.

[181] And that's exponential growth.

[182] So 100 becomes 130.

[183] A couple days later, that 130 becomes another 165 people have now been infected.

[184] And, you know, go over three weeks and 100 people become 500 people infected.

[185] Now, it doesn't take much to have those 100 people not infect 130, but infect 90.

[186] All we have to do is remove, say, 30, 40 percent of new infections from continuing their spread, and then instead of exponential growth, you have exponential decay.

[187] So this doesn't need to be perfect.

[188] We don't have to go from 100 to zero.

[189] We just have to go and have those 100 people infect 90, and those 90 people infect, you know, 82, whatever it might be.

[190] And you do that for, a few weeks, and boom, you have now gone, instead of 100 to 500, you've gone from 100 to 20.

[191] Yes.

[192] It's not very hard.

[193] And so the way to do that is to let people know that they're infectious.

[194] I mean, we're a perfect example right now.

[195] I, this morning, I used these tests to make sure that I wasn't infectious.

[196] Is it perfect?

[197] No, but it reduced my odds 99%.

[198] I already was at extremely low odds because I spent my life quarantining these days.

[199] Well, the interesting thing with this test, with testing in general, which is why I love what you've been espousing, and it's really confusing to me that this has not been taken on, is it's one actual solution that's those available for a long time.

[200] There doesn't seem to have been solutions proposed at a large scale, and a solution that it seems like a lot of people would be able to get behind.

[201] there's some politicization or fear of other solutions that people propose, which is like lockdown.

[202] And there's a worry, you know, especially in the American spirit of freedom, like you can't tell me what to do.

[203] The thing about tests is it like empowers you with information essentially.

[204] So like you, it's, it gives you more information about your, like your role in this pandemic and then you can do whatever the hell you want like it's all up to your ethics and so on so like and it's it's obvious that with that information people would be able to protect their loved ones and also do do their sort of quote unquote duty for their country right this protect the rest of the country that's exactly right i mean it's just it's empowerment but you know this is a problem we have not put these into action in large part because we have a medical industry that doesn't want to see them be used.

[205] We have a political and a regulatory industry that doesn't want to see them be used.

[206] That sounds crazy.

[207] Why wouldn't they want them to be used?

[208] We have a very paternalistic approach to everything in this country.

[209] Despite this country kind of being founded on this individualistic ideal, pull yourself up from your bootstraps, all that stuff.

[210] When it comes to public health, we have a bunch of ivory tower academics who, want data.

[211] You know, they want to see perfection.

[212] And we have this issue of letting perfection get in the way of actually doing something at all, you know, doing something effective.

[213] And so we keep comparing these tests, for example, to the laboratory -based PCR test.

[214] And sure, this isn't a PCR test, but this doesn't cost $100 and it doesn't take five days to get back, which means in every single scenario, this is the more effective test.

[215] And we have, unfortunately, a system that's not about public health.

[216] We have entirely eroded any ideals of public health in our country for the biomedical complex, you know, this medical industrial complex, which overrides everything.

[217] And that's why, you know, I'm just, can I swear on this podcast?

[218] Yes.

[219] I'm just so fucking pissed that these tests, don't exist.

[220] Meanwhile, and everyone says, you know, oh, we couldn't make these, you know, that we could never do it.

[221] That would be such a hard, a difficult problem.

[222] Meanwhile, the vaccine gets, we have, at the same time that we could have gotten these stupid little paper strip tests out to every household, we have developed a brand new vaccine.

[223] We've gone through phase one, phase two, phase three trials.

[224] We've scaled up its production.

[225] And now we have UPS and FedEx and all the logistics in the world, getting freezers out to where they need to be.

[226] We have this immense, we see when it comes to sort of medicine, you know, something you're injecting into somebody, then all of a sudden people say, oh, yes, we can.

[227] But you say, oh, no, that's too simple a solution, too cheap a solution.

[228] No way could we possibly do that?

[229] It's this faulty thinking in our country, which, you know, frankly, is driven by big money, big, you know, the only time when we actually think that we can do something that's maybe aggressive and complicated is when there's billions and billions and billions of dollars in it, you know, and I mean, on a difficult note, because this is part of your work from before the COVID.

[230] It does seem that I saw a statistic currently that 40 % would not be taken, of Americans would not be taking a vaccine, some, some number like this.

[231] So you also have to acknowledge that, all the money that's been invested, like, there doesn't appear to be a solution to deal with like the fear, distrust that people have.

[232] I bet, I don't know if you know this number, but for taking a strip, like a rapid test like this, I bet you people would say, like the percentage of people that wouldn't take it is in the single digits, probably.

[233] I completely think so.

[234] And, you know, there's a lot of people who don't want to get a test today.

[235] And that's because it gets sent to a lab.

[236] It gets reported.

[237] It has all this stuff.

[238] And we're a country which teaches people from the time they're babies, you know, to keep their medical data close to them.

[239] We have HIPAA.

[240] We have all these.

[241] We have immense rules and regulations to ensure the privacy of people's medical data.

[242] And then a pandemic comes around, and we just assume that all that the average person is going to wipe all that away and say, oh, no, I'm happy giving out, not just my own medical data, but also to tell the authority is everyone who I've spent my time with so that they all get a call and are pissed at me for giving up their names.

[243] You know, so people aren't getting tested, and they're definitely not giving up their contacts when it comes to contact tracing.

[244] And so for so many reasons, that approach is failing, not to even mention the delays in testing and things like that.

[245] And so this is a whole different approach, but it's an approach that empowers people and takes the power a bit away from the people in charge.

[246] You know, and that's what's really grading on, I think, public health officials who say, no, we need the data.

[247] So they're effectively saying, if I can't have the data, I don't want the individuals, I don't want the public to have their own data either, which is a terrible approach to a pandemic where we can't solve a public health crisis without actively engaging the public.

[248] It just doesn't work.

[249] And, you know, and that's what we're trying to do right now, which is a terrible approach.

[250] So first of all, there's a, you have a really nice informative website, rapid test .org, information on this.

[251] I still can't believe this.

[252] It's not more popular.

[253] It's ridiculous.

[254] Okay.

[255] But our, one of the FAQs you have is a rapid test too expensive.

[256] So can, can cost be brought down?

[257] Like, I pay, I take a weekly PCR test, and I think I pay 160, 170 bucks a week.

[258] No, I mean, it's criminal.

[259] Absolutely, we can get cost.

[260] This thing right here costs less than a dollar to make.

[261] With everything combined plus the swabs, you know, maybe it costs $1 .50.

[262] It could be sold for, frankly, it could be sold for $3 and still make a profit if they want to sell it for five.

[263] This one here.

[264] This is a slightly more complicated one, but you can see it's just got the exact same paper strip inside.

[265] This is really, it doesn't look like much.

[266] but it's kind of the cream of the crop in terms of these rapid tests.

[267] This is the one that the U .S. government bought, and it is doing an amazing job.

[268] It has a 99 .9 % sensitivity and specificity, so it's really good.

[269] And so essentially the way it works is you just, you use a swab.

[270] You put the, once you kind of use the swab in yourself, you put the swab into these little holes here.

[271] You put some buffer on and you close it, and a line will show up if it's positive, and a line won't show up.

[272] but it's negative.

[273] It takes five, ten minutes.

[274] This whole thing, this can be made so cheap that the U .S. government was able to buy them by 150 million of them from Abbott for $5 a piece.

[275] You know, so anyone who says that these are expensive, we have the proof is right here.

[276] This one at its, you know, was Abbott did not lose money on this deal.

[277] You know, they got $750 million for selling $150 million of these at $5.

[278] bucks piece.

[279] All of these tests can do the same.

[280] So anyone who says that these should be, you know, unfortunately what's happening, though, is the FDA is only authorizing all of these tests as medical devices.

[281] So what happens when you, if I'm a medical company, if I'm a test production company and I want to make this test, and I go through and the FDA, at the end of my authorization, the FDA says, okay, you know, you now have a medical device.

[282] not a public health tool, but a medical device.

[283] And that affords you the ability to charge insurance companies for it.

[284] Why would I ever, as a, you know, in our capitalistic economy and sort of infrastructure, why would I ever not sell this for $30 when insurance will pay for it or $100?

[285] You know, it might only cost me 50 cents to make, but by pushing all of these tests through a medical pathway at the FDA, what, what, extrudes out the other side is an expensive medical device that's erroneously expensive.

[286] It doesn't need to be inflated in cost.

[287] But the companies say, well, I'd rather make fewer of them and just sell them all for $30 a piece than make tens of millions of them, which I could do, and sell them at a dollar marginal profit.

[288] And so it's a problem with our whole medical industry that we see tests only as medical devices.

[289] And, you know, what I would like to see is for the government, in the same way that they bought 150 million of these from Abbott, they should be buying, you know, all of these tests that they should be buying 20 million a day and getting them out to people's homes.

[290] This virus has cost trillions of dollars to the American people.

[291] It's closed down restaurants and stores and, you know, obviously the main streets across America have shutered.

[292] It's killing people.

[293] It's killing our economy.

[294] It's killing life.

[295] styles and lines.

[296] This is an obvious solution.

[297] To me this is exciting.

[298] This is like this is a solution.

[299] I wish like in April or something like that to launch like the larger scale manufacturing deployment of tests.

[300] It doesn't matter what tests they are.

[301] Obviously the capitalist system would create cheaper and cheaper tests that would be hopefully driving down to $1.

[302] So what are we talking about?

[303] In America there's, I don't know, 300 plus a million people.

[304] So that means you want to be testing regularly, right?

[305] So how many do you think is possible to manufacture?

[306] What would be the ultimate goal to manufacture per month?

[307] Yep.

[308] So if we want to slow this virus and actually stop it from transmitting, achieve what I call herd effects.

[309] Like vaccine, herd immunity, herd effects are when you get that R value below one through preventing onward transmission.

[310] If we want to do that with these tests, we need about 20 million to 40 million of them every day, which is not a lot.

[311] In the United States.

[312] In the United States.

[313] So we could do it.

[314] There's other ways you can have two people in a household, swab each other, you know, swab themselves, rather, and then mix, you know, put the swabs into the same tube and onto one test.

[315] So you can pool.

[316] So you can get a two or three X gain in efficiency through pooling in the household.

[317] could do that in schools or offices, too, where everyone just use a swab.

[318] You have a, there's two people, like, I mean, even if it's just standing in line at a public testing site or something, you know, you could just say, okay, these two are the last people to test or swab themselves.

[319] They go into one thing.

[320] And if it comes back positive, then you just do each person, and, you know, it's rapid.

[321] So you can just say to the people, one of you's positive, let's test you again.

[322] So there's ways to get the efficiency gains much better.

[323] But let's say, I think that the, the, that the optimal number right now that matches sort of what we can produce more or less today if we want it is 20 million a day.

[324] Right now, one company that, I don't have their test here, but one company is already producing five million tests themselves and shipping them overseas.

[325] It's an American company based in California called the Nova, and they are giving five million tests to the UK every day.

[326] Not to the, you know, and this is just because there's no, the federal government hasn't authorized these tests.

[327] Without the support of the government.

[328] So, yeah, so essentially if the government just puts some support behind it, then, yeah, you can get $20 million, probably easy.

[329] Oh, yeah, this, I mean, just here I have three different companies.

[330] These, they all look similar.

[331] Well, this one's closed, but these are three different companies right here.

[332] This is a fourth, Abbott.

[333] Now, this is a fifth.

[334] This is a sixth.

[335] These two are a little bit different.

[336] Do you mind if, in a little bit, would you take some of these?

[337] Yeah, let's do it.

[338] We can absolutely do them.

[339] So you have a lot of tests in front of you.

[340] Could you maybe explain some of them?

[341] Absolutely.

[342] So there's a few different classes of tests that I just have here.

[343] And there's more tests.

[344] There's many more different tests out in the world, too.

[345] These are one class of test.

[346] These are rapid antigen tests that are just the most bare bones paper strip tests.

[347] These are, this is the type that I want to see produced in the tens of millions every day.

[348] It's so simple.

[349] You know, you don't even need the plastic cartridge.

[350] You can just make the paper strip and you could have a little tube like this that, you know, you just dunk the paper strip into.

[351] You don't actually need the plastic, which I'd actually prefer because if we start making tens of millions of these, this becomes a lot of waste.

[352] So I'd rather not see this kind of waste be out there.

[353] And there's a few companies, Quidel is making a test called The Quick View, which is just this.

[354] They've gotten rid of all the plastic.

[355] And for people who are just listening to this, we're looking at some very small tests that fit in the palm of your hand, and they're basically paper strips fit into different containers.

[356] And that's hence the comment about the plastic containers.

[357] These are just injection molded, I think.

[358] and they're, you know, they can build them at high numbers, but then they have to, like, place them in there appropriately and all this stuff.

[359] So it is a, it is a bottleneck, or somewhat of a bottleneck in manufacturing.

[360] The actual bottleneck, which the government, I think, should use the Defense Productions Act to build up, is the, there's a nitrocellulose membrane, a laminated membrane on this, that allows the material, the buffer with a swab mixture to flow across it.

[361] So the way these work, they're called lateral flow tests, and you take a swab, you swab the front of your nose, you dunk that swab into some buffer, and then you put a couple drops of that buffer onto the lateral flow.

[362] And just like paper, if you dip a piece of paper into a cup of water, the paper will pull the water up through capillary action.

[363] This actually works very similarly at flows through somewhat a capillary reaction through this nitrocellulus membrane, and there's little antibodies on there, these little proteins that are very specific, in this case for antigens or proteins of the virus.

[364] So these are antibodies similar to the antibodies that our body makes from our immune system, but they're just printed on these lateral flow tests, and they're printed just like a little line.

[365] So then you slice these all up into individual ones.

[366] And if there's any virus on that buffer as it flows across, the antibodies grab that virus, and it creates a little reaction with some colloids in here that cause it to turn dark.

[367] Just like a pregnancy test, one line means negative.

[368] It means a control strip worked, and two lines mean positive.

[369] It means, you know, but if you get two lines, it just means you have virus there.

[370] You're very, very likely to have virus there.

[371] And so they're super simple.

[372] This is, it is the exact same technology as pregnancy tests.

[373] It's the technology, this particular one from Abbott, this has been used for, for other infectious diseases like malaria and actually a number of these companies have made malaria tests that do the exact same thing.

[374] So they just co -opted the same form factor and just changed the antibodies.

[375] So it picks up SARS -CoF2 instead of other infections.

[376] Is it also the Abbott one?

[377] Is it also strip?

[378] Yep.

[379] Yeah.

[380] This Abbott one here is there's the, in this case, instead of being put in a plastic sheath, it's just put in a cardboard thing and literally glued on.

[381] I mean, it's, it looks like nothing.

[382] You know, it's just, it looks like a, like, I mean, it's just the simplest thing you could, you could imagine.

[383] The exterior packaging looks very Apple -like.

[384] It's nice.

[385] It does, yeah.

[386] Yeah.

[387] Yeah, so it's nice.

[388] And it comes in, this is the, this is how they're packaged, you know, so, and they don't have to, you know, this, these are coming in individual packages against, again, because they're really considered individual medical devices.

[389] But you could package them in, you know, bigger packets and stuff.

[390] You, you want to be careful with, you know, so they all have a little, one of those humidity removing things and oxygen removing things.

[391] So that's, this is one class, these antigen tests.

[392] If we could just pause for a second, if it's okay, and could you just briefly say what is an antigen test and what other tests there are out there, like categories of tests?

[393] Sure.

[394] Just really quick.

[395] So the testing landscape is a little bit complicated, but it's, but I'll break it down.

[396] There's really just three major classes of tests.

[397] We'll start with the first two.

[398] The first two tests are just looking for the virus or looking for antibodies against the virus.

[399] So we've heard about serology tests, or maybe some people have heard about it.

[400] Those are a different kind of test.

[401] They're looking to see, has somebody in the past, does somebody have an immune response against the virus, which would indicate that they were infected or exposed to it.

[402] So we're not talking about the antibody tests.

[403] I'll just leave it at that.

[404] Those, they actually can look very similar to this, or they can be done in a laboratory.

[405] Those are usually done from blood, and they're looking for an immune response to the virus.

[406] So that's one.

[407] Everything I'm talking about here is looking for the virus itself, not the immune response to the virus.

[408] And so there's two ways to look for the virus.

[409] You can either look for the genetic code of the virus, like the RNA, just like the DNA of somebody's human cells, or you can look for the proteins.

[410] themselves, the antigens of the virus.

[411] So I like to differentiate them.

[412] If you were a PCR test that looks for RNA in, let's say if we made it against humans, it would be looking for the DNA inside of our cells.

[413] That would be actually looking for our genetic code.

[414] The equivalent to an antigen test is sort of a test that actually is looking for our eyes or our nose or physical features of our body that would delineate, okay, this is Michael, for example.

[415] And so you're either looking for a sequence or you're looking for a structure.

[416] The PCR tests that a lot of people have gotten now and they're done in labs usually are looking for the sequence of the virus, which is RNA.

[417] This test here by a company called Detect, this is one of Jonathan Rothberg's companies.

[418] he's the guy who helped create modern day sequencing and all kinds of other things.

[419] So this detect device, that's just the name of the company, this is actually a rapid RNA detection device.

[420] So it's almost, it's like a PCR -like test, and we could even do it here.

[421] It's really, it's a beautiful test, in my opinion.

[422] It works exceedingly well.

[423] It's going to be a little bit more expensive, so I think it could confirm, could be used as a confirmatory test for these.

[424] Is there a greater accuracy to it?

[425] Yes, I would say that there is a greater accuracy.

[426] There's also a downfall, though, of PCR and tests that look for RNA.

[427] They can sometimes detect somebody who is no longer infectious.

[428] So you have the RNA test, and then you have these antigen tests.

[429] The antigen tests look for structures, but they're generally only going to turn positive if people have actively replicating virus in them.

[430] And so what happens after an infection dissipates, you have, you've just gone from having sort of a spike.

[431] So if you get infected, maybe three days later, the virus gets into exponential growth, and it can replicate to trillions of viruses inside the body.

[432] Your immune system then kind of tackles it and beats it down to nothing.

[433] But what ends up in the wake of that, you just had a battle.

[434] You had this massive battle that just took place inside your upper respiratory tract.

[435] And because of that, you've had trillions and trillions of viruses go to zero, essentially.

[436] But the RNA is still there.

[437] It's these remnants in the same way that if you go to a crime scene and blood was sort of spread all over the crime scene, you're going to find a lot of DNA.

[438] There's tons of DNA.

[439] There's no people anymore, but there's a lot of DNA there.

[440] Same thing happens here.

[441] And so what's happening with PCR testing is when people go and use these exceedingly high sensitivity PCR tests, people will stay positive for weeks or months after their infection has subsided, which has caused a lot of problems, in my opinion.

[442] It's problems that the CDC and the FDA and doctors don't want to deal with.

[443] But I've tried to publish on it.

[444] I've tried to, you know, suggest that this is an issue, both to New York Times and others, and now it's unfortunately kind of taken on a life of its own of conspiracy theorists thinking they call it a case demic.

[445] They say, oh, you know, PCR is detecting people who are no long, who are false positive.

[446] They're not false positives.

[447] They're late positives, no longer transmissible.

[448] I think the way you, like what I saw in rapid test .org, I really like the distinction between diagnostic sensitivity and contagiousness sensitivity.

[449] That's so, that website is so obvious that it's painful because it's like, yeah, that's what we should be talking about is how accurately is a test able to detect.

[450] your contagiousness.

[451] And you have different plots that show that actually there's, you know, that antigen tests, the tests we're looking at today, like rapid tests, are actually really good at detecting contagiousness.

[452] Absolutely.

[453] It all mixes back with this whole idea that of the medical industrial complex.

[454] You know, in this country, and in most countries, we have almost entirely defunded and devalued public health.

[455] period.

[456] You know, we just, we just have.

[457] And, uh, and what that means is that we don't even, we don't have a language for it.

[458] We don't have a lexicon for it.

[459] We don't have a regulatory landscape for it.

[460] And so the only window we have to look at a test today is as a medical diagnostic test.

[461] And, uh, and that becomes very problematic when we're trying to tackle a public health threat and a public health emergency by definition.

[462] This is a public health emergency that we're in.

[463] And yet we keep evaluating tests as though the diagnostic benchmark is the gold standard, where if I'm a physician, I am a physician, so I'll put on that physician hat for a moment.

[464] And if I have a doctor, if I have a patient who comes to me and wants to know if their symptoms are a result of them having COVID, then I want every shred of evidence that I can get to see, does this person currently or did they, recently have this infection inside of them.

[465] And so in that sense, the PCR test is the perfect test.

[466] It's really sensitive.

[467] It will find the RNA if it's there at all so that I could say, you know, yeah, you have a low amount of RNA left.

[468] You might have been, you said your symptoms started two weeks ago.

[469] You probably were infectious two weeks ago and you have lingering symptoms from it.

[470] But that's a physical diagnosis.

[471] It's kind of like a detective, recreating a crime scene.

[472] They want to go back there and recreate the pieces so that they can assign blame or whatever might be.

[473] But that's not public health.

[474] In public health, we need to only look forward.

[475] We don't want to go back and say, well, was this person, are there symptoms because they had an infection two weeks ago?

[476] In public health, we just want to stop the virus from spreading to the next person.

[477] And so that's where we don't care if somebody was infected two weeks ago.

[478] We only care about finding the people who are infectious today.

[479] And unfortunately, our regulatory landscape fails to apply that knowledge to evaluate these tests as public health tools.

[480] They're only evaluating the tests as medical tools.

[481] And therefore, we get all kinds of complaints that say this test, which detects 99 plus, you know, 99 .8 % of current infected people, by the FDA's rubric, they'll say, no, no, it's only 50 % sensitive.

[482] And that's because when you go out into the world and you just compare this against PCR positivity, most people who are PCR positive in the world right now at any given time are post -infectious.

[483] They're no longer infectious because you might only be infectious for five days, but then you'll remain PCR positive for three or four or five weeks.

[484] And so when you go and just evaluate these tests and you say, okay, this person's PCR positive, does the rapid antigen test detect that?

[485] More often than not, it's no. But that's because those people don't need isolation.

[486] You know, they're post -infectious.

[487] And this is a, it's become much more of a problem than I think even the FDA themselves is recognizing because they are unwilling at this point to look at this as a public health problem requiring public health tools.

[488] We'll definitely talk about this a little bit more because the concern I have is that like a bigger pandemic comes along.

[489] What are the lessons we draw from this and how we move forward?

[490] Let's talk about that in a bit.

[491] But so can we discuss further the lay of the land here of the different tests before us?

[492] Absolutely.

[493] So I talked about PCR tests and those are done in the lab or they're done essentially with a rapid test like this, the detect.

[494] And we can even try this in a moment.

[495] It goes into a little heater, so you might have one of these in a household or one of these in a nursing home or something like that, or in an airport, or you could have one that has a hundred different outlets.

[496] This is just to heat the tube up.

[497] These are the rapid tests.

[498] They are super simple, no frills.

[499] You just swab your nose, and you put the swab into a buffer, and you put the buffer on the test.

[500] So we can use these right now if you want.

[501] Yeah.

[502] We can try it out.

[503] And all the tests we're talking about, they usually swabbing the nose.

[504] Like, that's the...

[505] That's still the main, yeah.

[506] There are some saliva tests coming about, and these can all work potentially with saliva.

[507] They just have to be recalibrated.

[508] But these swabs are really not bad.

[509] This isn't the deep swab that goes, like, way back into your nose or anything.

[510] This is just a swab that you do yourself, like, right in the front of your nose.

[511] So if you want to do it...

[512] Yeah, do you mind if I...

[513] Sure, yeah.

[514] Yeah, why don't we start with this one?

[515] Because this is the Abbott's Bynex Now test, and it's really, it's pretty simple.

[516] This is the swab from the Abbott test.

[517] That's correct.

[518] That's the swab from the Abbott test.

[519] So what I'm going to do to start is I'm going to take this buffer here, which is, this is just the buffer that goes on to this test.

[520] So this is a brand new one.

[521] I just opened this test out.

[522] I'm going to just take six drops of this buffer.

[523] and put it right onto this test here.

[524] Two, three, four, five, six.

[525] Okay.

[526] And now you're going to take that swab.

[527] Open it up.

[528] Yep.

[529] And now just wipe it around inside the, into the front of your nose, do a few circles on each nostril.

[530] That looks good.

[531] This always makes me want to sneeze.

[532] Yeah.

[533] Okay, now I'm going to have you do it yourself.

[534] I'm getting emotional.

[535] hold it parallel to the test so put the test down on the table yep and then go into that bottom hole yep and push forward so you can start to see it in the other hole there you go and now turn once it hits up against the top just turn it three times one two three and sort of yep and now you just close to pull off that adhesive sticker there and now you just close the whole thing and that's it that's it now what we will see uh is we will see uh align form what's happening now is the the buffer that you put in there is uh now uh moving up onto the paper strip test and it has the material from the swab in there and so what we'll see is a line will form uh and that's going to be the control line and then we'll also see ideally we'll see no line for the actual test line and that's because you should be negative so one line will be positive and two lines will be negative it's very cool there's this purple thing creeping up onto the control line that's perfect that's what you want to be seeing so you want to see that so right now you are want to see that that blue line turns pink or purply color.

[536] There's a blue line that's already there printed.

[537] It should turn sort of a purple pink color.

[538] And ideally, there will be no additional line for the sample.

[539] And if there is, that's the 99 point whatever percent accuracy on.

[540] That means I have, I'm contagious.

[541] That would mean that you're likely contagious.

[542] or you likely have infectious virus in you.

[543] What we can do, because one of the things that my plan calls for is because sometimes these tests can get false positive results, it's rare, maybe 1%, or in the case of this by next now, this Abbott test, 0 .1%, so 1 in 1 ,500, something like that, can be falsely positive.

[544] What I recommend is that when somebody is positive on one of these, you turn around and you immediately test on a different test.

[545] You could either do it on the same, but for as good measure, you want to use a separate test that is somewhat orthogonal, meaning that it shouldn't turn falsely positive for the same reason.

[546] This particular test here, this detect test, because it is looking for the RNA and not the antigen, this is an amazingly accurate test, and it's sort of a perfect gold standard or a confirmatory test for any of these antigen tests.

[547] So one of the recommendations that I've had, especially if people start using antigen tests before you get onto a plane or, you know, as what I call entrance screening, if somebody's positive, you don't immediately tell them your positive go isolate for 10 days.

[548] You tell them, let's confirm on one of these, on a detect test.

[549] that is a, because it's completely orthogonal, it's looking for the RNA instead of the antigen.

[550] There's no reason, no biological reason, that both of these should be falsely positive.

[551] So if one's falsely positive and the other one is negative, especially because this one's more sensitive, then I would trust this as a confirmatory test.

[552] If this one's negative, then the antigen test, you know, would be considered falsely positive.

[553] It does look like there's only a single line, so this is very exciting news.

[554] That's right, yep.

[555] It says wait 15 minutes to see both lines, but in general, if somebody's really going to be positive, that line starts showing up within a minute or two.

[556] So you want to keep the whole, we'll keep watching it for the whole 15 minutes as it's sitting there, but I would say you're, knowing that you've had PCR tests recently and all that, you know.

[557] The odds are pretty good.

[558] The odds are very good.

[559] Packaging, very iPhone -like.

[560] I'm digging this sexy packaging.

[561] I'm a sucker for good packaging.

[562] Okay.

[563] So then there's this test here, which is, you know, this is another, you know, it's funny.

[564] Let me let me open this up and show you.

[565] This is a really nice test.

[566] It's another antigen test.

[567] Works the exact same way as this, essentially.

[568] But what you can see is it's got like lights in it and a power button and stuff.

[569] This is called an allume test, which is, you know, fine.

[570] And it's a really nice test.

[571] test, to be honest, but it has to pair with an iPhone.

[572] And so it's good as a, I think that this is going to become, this is, there's a lot of use for this from a medical perspective, you know, where you want good reporting.

[573] This can, because it pairs of an iPhone, it can immediately send, send the report to a Department of Health, whereas these paper strip tests that, they're just paper, they don't report anything unless you want to report it.

[574] And so I'm going to just pick it apart.

[575] And so you can see is there's like fluorescent readers and little lasers and LEDs and stuff in there.

[576] You can actually see the lights going off.

[577] Oh.

[578] And there's a paper strip test right inside there.

[579] But you can see that there's like a whole circuit board and all this stuff.

[580] Mm -hmm.

[581] Right.

[582] And so this is the kind of thing that, you know, the FDA is looking for for like home use and things like that because it's kind of foolproof.

[583] feel like you can't go wrong with it.

[584] It pairs with an iPhone, so you need Bluetooth.

[585] So it's going to be more limited.

[586] It's a great test.

[587] Don't get me wrong.

[588] It's as good as any of these.

[589] But, you know, when you compare this thing with a battery and a circuit board and all this stuff, it's got its purpose, but, you know, it's not a public health tool.

[590] I don't want to see this made in the tens of millions a day and thrown away.

[591] But FDA likes that kind of stuff.

[592] FDA loves this stuff, you know, because they can't get it out of their mind that this is a public health crisis.

[593] You know, we need, we need, I mean, just look at the difference here.

[594] Something with flashing lights is essential.

[595] Got batteries, it's got a Bluetooth thing.

[596] It's a great test, but, you know, it's, to be honest, it's not any better than this one.

[597] And so, you know, I want this one.

[598] It's nice and all.

[599] The form factor is nice, but, and it's really nice that it goes to Bluetooth.

[600] But it goes against the principle of just 20 million a day.

[601] Exactly.

[602] The easy solution.

[603] Everybody has that you can manufacture, and probably, you could have probably scaled this up in a couple of weeks.

[604] Oh, absolutely.

[605] These companies, I mean, the rest of the world has these.

[606] They can be scaled up.

[607] They already exist.

[608] You know, SD biosensis, one company is making tens of millions a day, not coming to the United States, but going all over Europe, going all over Southeast Asia and East Asia.

[609] So they exist.

[610] The U .S. is just, you know, we can't get out of our own way.

[611] I wonder why somebody, I don't know if you were paying attention, but somebody like an Elon Musk type character.

[612] So he was really into doing some, like, obvious engineering solution.

[613] Like, this at -home rapid test seems like a very Elon Musk thing to do.

[614] I don't know if you saw, but I had a little Twitter conversation with Elon Musk.

[615] Does he not like?

[616] Do you know what his thoughts are on rapid testing?

[617] Well, he was using a slightly different one, one of these, but that requires an instrument called the BD Veritor.

[618] And he got a false positive.

[619] Or, no, I shouldn't say.

[620] He didn't necessarily get a false positive.

[621] positive.

[622] He got discrepant results.

[623] He did this test four times.

[624] He got two positives, two negatives.

[625] But then he got a PCR test, and it was a very low positive result.

[626] So I think what happened is he just tested himself at the tail end of an...

[627] This was actually right before he was about to send those.

[628] It was the day of, essentially, that he was sending the astronauts up to the space station the other day.

[629] So he was using these rapid tests because he wanted to make sure that he was good to go in, and he got discrepant results.

[630] Ultimately, they were correct.

[631] But, you know, two were negative, two were positive.

[632] But what really happened, once he got his, he shared his PCR results, and they were very low, positive.

[633] So really what was happening is, my guess, is he found himself right at the edge of his positivity, of his infectiousness.

[634] And so, you know, the test worked how it was supposed to work.

[635] It probably had he used it two days earlier, it would have been screaming positive.

[636] You know, he wouldn't have gotten discrepant results.

[637] But he found himself right at the edge by the time he used the test.

[638] So the PCR would always pick it up because it's still, because that will still stay positive then for weeks potentially.

[639] But the rapid antigen test was starting to falter, not in a bad way, but just he probably was really no longer particularly infectious.

[640] And so it was kind of when it gets to be a very low viral load, it becomes stochastic.

[641] It's fascinating.

[642] This is this duality.

[643] So one, you can think from an individual perspective, it's unclear when you take four and half are positive, half a negative, like, what are you supposed to do?

[644] But from a societal perspective, it seems like if just one of them is positive, just stay home for a couple days, for a while.

[645] So when you're a CEO of a company, you're launching astronauts to space, you may not want to rely absolutely on the antigen test as a thing by which you steer your decisions of like 10 ,000 plus people companies.

[646] But us individuals just living in the world, if it comes up positive, then you make decisions based on that.

[647] And then that scales really nicely to an entire society of hundreds of millions of people.

[648] And that's how you get that virus to stop spreading.

[649] That's exactly right.

[650] You don't have to catch every single one.

[651] And the nice thing is that these will, these will catch the people who are most infectious.

[652] So with Elon Musk, it generally, that test, we don't have the counterfactual.

[653] We don't have his results from three days earlier when he was probably most infectious.

[654] But my guess is the fact that it was catching two out of the four, even when he was down at a CT value, a really, really very, very low viral load on the PCR test suggests that it was doing its job.

[655] And you just want to, and the nice thing is because these can be produced at such scale, getting one positive doesn't immediately have to mean 10 days of isolation.

[656] That's the CDC's more conservative stance to say, if you're positive on any test, stay home for 10 days and isolate.

[657] But here, people would just have more tests.

[658] So the recommendation should be test daily.

[659] If you turn positive, test daily until you've been negative for 24, 48 hours, and then go back to work.

[660] And the nice thing there is, you know, right now people just aren't testing because they don't want to take 10 days off.

[661] They're not getting paid for it, so they can't take 10 days off.

[662] Do you know what Elon thinks about this idea of rapid testing for everybody?

[663] So I understood, I need to look at that whole Twitter thread.

[664] So I understand his perhaps criticism of, he had like a conspiratorial tone from my vague look at it of like, what's going on here with these tests.

[665] But what does he actually think about this very practical to me, engineering solution of just deploying rapid tests to everybody.

[666] It seems like that's a way to open up the economy in April.

[667] Well, to be honest, I've been trying to get in touch with them again.

[668] I think take somebody like Elon Musk with the engineering prowess within his ranks, you know, to easily, easily build these at the tens of millions a day.

[669] He could build the machines from scratch.

[670] You know, a lot of the companies, they buy the machines from South Korea or Taiwan, I believe, we don't have to like we can build these machines they're simple to build get put somebody like Elon Musk on it you know take some of his best engineers and say look the US needs a solution in two weeks build these machines you know figure it out he'll do it he could do it this is a guy who who is literally he has started multiple entirely new industries he has the capital to do it without the US government if he wanted to, and you know what, it would, the return on investment for him would be huge.

[671] But frankly, the return on investment in the country would be hundreds of billions of dollars, because it means we could get society open.

[672] So I know that he, his first experience with these rapid tests, was confusing, which is how I ended up having this Twitter kind of conversation with him very briefly.

[673] But I think that if he understood sort of a little bit more, and I think he does, I really love to talk to him about it because I think he could totally change the course of this pandemic in the United States single -handedly.

[674] You know, he loves grand things.

[675] Yeah, I think out of all the solutions I've seen, this is this is the obvious like engineering solution to at least a pandemic of this scale.

[676] I love that you say the engineering solution.

[677] So this is something I've been really trying to, I'm an engineer, you know, my my previous history was all engineering, and that's really how I think.

[678] I then went into medicine and Ph .D. world, but, but I, I think that the world, like, one of the major catastrophes or one of the major problems is that we have physicians making the decisions about public health and a pandemic when really we need engineers.

[679] This is an engineering problem.

[680] And so what I've been trying to do, I actually really want to, you know, start a whole new, a new, field called public health engineering, you know.

[681] And so I've been, eventually I want to try to bring it to MIT and get MIT to want to start a new department or something.

[682] That's, it's a doubly awesome idea.

[683] Okay, I love this.

[684] I love every aspect.

[685] I love everything you're talking about.

[686] A lot of people believe because vaccines started being deployed currently that, you know, we are no longer in need of a solution.

[687] We're no longer in need of slowing the spread of the virus.

[688] To me, as I understand, it seems like this is the most important time to have something like a rapid testing solution.

[689] Can you kind of break that apart?

[690] What's the role of rapid testing in the next, you know, what is it, three, four months maybe?

[691] Even more.

[692] The vaccine rollout isn't going to be as peachy as everyone is hoping.

[693] You know, and I hate to be the Deppie Downer here, but there's a lot of unknowns with this vaccine.

[694] You've already mentioned one, which is there's a lot of people who just don't want to get the vaccine.

[695] You know, I hope that that might change as things move forward and people see their neighbors getting in and their family getting it, and it's safe and all.

[696] We don't know how effective the vaccine is going to be after two or three months.

[697] We've only measured it in the first two or three months, which is a massive problem, which we can go into biologically, because there's reasons to, very good reasons to believe that the efficacy could fall way down after two or three months.

[698] We don't know if it's going to stop transmission, and if it doesn't stop transmission, then we're not, then there's, you know, herd immunity is much, much more difficult to get because that's all based on transmission blockade.

[699] And frankly, we don't know how easily we're going to be able to roll it out.

[700] Some of the vaccines need really significant cold chains, have very short half -lives outside of that cold chain.

[701] We need to organize massive numbers of people to be able to distribute these.

[702] Most hospitals today are saying that they're not equipped to hire the right people to be even administering enough of these vaccines.

[703] And then a lot of the hospitals are frustrated because they're getting much smaller allocations than they were expecting.

[704] So I think right now, like you say, right now is the best time, you know, besides three or four or five or six months ago, right now is the best time to get these rapid tests out.

[705] And we need to, I mean, the country has the capacity to build them.

[706] We have, we're shipping them overseas right now.

[707] We just need to flip a switch, get the FDA to recognize that there's more important things than diagnostic medicine, which is the effectiveness of the public health program when we're dealing with a pandemic.

[708] They need to authorize these as public health tools or, you know, frankly, the president's could.

[709] You know, there's a lot of other ways to get these tests to not have to go through the normal FDA authorization program, but maybe have the NIH and the CDC give a stamp of approval.

[710] And if we could, we could get these out tomorrow.

[711] And that's where that article came from, you know, how we can stop the spread of this virus by Christmas.

[712] We could.

[713] You know, now it's getting late.

[714] And so we have to keep updating that time frame, maybe putting Christmas in the title wasn't, I should have said, how we can stop the spread of this virus in a month, it would be a little bit more timeless.

[715] But, uh, but we could do it.

[716] You know, we really could do it.

[717] And that's the most frustrating part here is that, uh, we're just choosing not to as a country.

[718] We're choosing to bankrupt our society because some people at the FDA and other places just can't seem to get their head around the fact that this is a public health problem, not a bunch of medical problems.

[719] Is there a way to change that policy wise?

[720] So this is, this is a much bigger thing that you're speaking to, which I love in terms of the MIT engineering approach to public health.

[721] Is there a way to push this?

[722] Is this a political thing, like where some Andrew Yang type characters need to like start screaming about it?

[723] Is it more of an Elon Musk thing where people just need to build it and then on Twitter start talking crap to politicians for not doing it?

[724] What What are the ideas here?

[725] I think it's a little of both.

[726] I think it's political on the one hand, and I've certainly been talking to Congress a lot, talking to senators.

[727] Are they receptive?

[728] Oh, yeah.

[729] I mean, that's the crazy thing.

[730] Everyone but the FDA is receptive.

[731] I mean, it's astounding.

[732] I mean, I advise, you know, informally, I advise the president and the president -elects teams.

[733] I talk to Congress.

[734] I talk to senators, governors, you know, and then all the way down to, you know, mayors of towns and things.

[735] And I mean, months ago, I held a roundtable discussion with Mayor Garcetti, who's the mayor of L .A., and I brought all the, all the companies who make these things.

[736] This was in, like, July or August or something.

[737] I brought all the companies to the table and said, okay, how can we get these out?

[738] And unfortunately, it went nowhere because the FDA won't authorize them as public health tools.

[739] the nice thing is that this is one of the nice and frustrating things.

[740] This is one of the few bipartisan things that I know of.

[741] And like you said, it's a real solution.

[742] Lockdowns aren't a solution.

[743] They're an emergency bandaid to a catastrophe that's currently happening.

[744] They're not a solution.

[745] And they're definitely not a public health solution if we're taking a more holistic view of public health, which includes people's well -being, includes their psychological.

[746] well -being, their financial well -being, you know, just stopping a virus if it means that all those other things get thrown under the bus is not a public health solution.

[747] It's a, it's a, it's a, it's a myopic or very tunnel -visioned approach to a viral virus that's spreading.

[748] This is a simple solution with essentially no downfall.

[749] You know, there is no, nothing bad about this.

[750] It's just giving people a result.

[751] And it's bipartisan, you know, the most conservative and the most liberal people.

[752] Everyone just wants to know their status.

[753] You know, nobody wants to have to wait in line for four hours to find out their status on Monday a week later on Saturday.

[754] You know, it just doesn't make any sense.

[755] It's a useless test at that point.

[756] And everyone recognizes that.

[757] So why do you think, like the mayor of L .A., why do you think politicians are going for these, from my perspective, like kind of half -ass lockdowns, which is not, so I have seen good evidence that like a complete lockdown can work, but that's in theory, it's just like communism in theory can work.

[758] Like theoretically speaking, but it just doesn't, at least in this country, we don't, I think it's just impossible to have complete lockdown.

[759] And still, politicians are going for these kind of lockdowns that everybody hates that's really destroying really hurting small businesses like why are they going and big businesses and yeah all businesses but like basically not just hurting yeah they're destroying small businesses right which is going to have potentially I mean long -lasting yeah I've been reading as I don't shout up about the rise and fall of the Third Reich and, you know, there's economic effects that take a decade to, you know, there's going to be long -lasting effects that may be destructive to the very fabric of this nation.

[760] So why are they doing it and why are they not using the solution?

[761] Is there, is there an intuition?

[762] I mean, you've said the FDA has a stranglehold, I guess, on this whole public health problem.

[763] Is that, is that all it is?

[764] That's honest.

[765] it's pretty much all it is.

[766] The companies, so somebody like Mayor Garcetti or Governor Baker, Cuomo, Newsom, any of these, DeWine, I've talked to, you know, I've talked to a lot of governors in this country at this point, and, of course, the federal government, including the president's own teams, you know, and the heads of the NIH, the heads of the CDC about this.

[767] The problem is the tests don't exist in this country at the level that we need them to right now to make that kind of policy, to make that kind of program.

[768] They could, but they don't.

[769] And so what that means is that when Mayor Garcetti says, okay, what are my actual options today, despite these sounding like a great idea, he looks around and he says, well, they're not authorized.

[770] right now for at -home use.

[771] And from his perspective, he's not about to pick that fight with the FDA.

[772] And it turns out nobody is.

[773] Why are people afraid of it?

[774] It seems like an easy strong -in -at -the -fight.

[775] It's like - Well, it's not a, so they don't see it as a fight.

[776] They think that the FDA is the end -all -be -all.

[777] Everyone thinks the FDA is the end -all -b -all.

[778] And so they just defer, everyone is deferential, including the heads of all the other government agencies, because that is their role.

[779] But what everyone is failing to see is that the FDA doesn't even have a mandate or a remit to evaluate these tests as public health tools.

[780] So they're just falling in this weird gray zone where the FDA is saying, look, we evaluate medical products.

[781] That's the only thing that I meant, like Tim Stenzel, head of in vitro diagnostics at the FDA.

[782] He's doing what his job is, which is to evaluate medical tools.

[783] unfortunately, this is where I think the CDC has really blundered.

[784] They haven't made the right distinction to say, look, okay, the FDA is evaluating these for doctors to use and all that, but, you know, we're the CDC and we're the public health agency of this country, and we recognize that these tools require a different authorization pathway and a different use, not prescriptions.

[785] There's a difference in medical devices and public health, and I guess FDA is not designed for this public health, especially in emergency situations.

[786] And they actually explicitly say that.

[787] I mean, when I go and talk to Tim, you know, he's a very reasonable guy.

[788] But when I talk to him, he says, look, we don't.

[789] We just do not evaluate a public health tool.

[790] If you're telling me this is a public health tool, great, go and use it.

[791] And so I say, okay, great, we'll go and use it.

[792] And then the comment is, but, you know, does it give a result back?

[793] to somebody.

[794] I say, well, yes, of course it gives a result back to somebody.

[795] It's being done in their home.

[796] So, well, then it's defined as a medical tool.

[797] You can't use it.

[798] So it's stuck in this gray zone where we, unfortunately, there's this weird definition that any tool, any, any test that gives a result back to an individual is defined by CMS, Centers for Medicaid Services, as a medical device requiring medical authorization.

[799] But then you go and ask, it gets crazier, because then you go and ask Sima Verma, the head of CMS, you know, okay, can these be authorized as public health tools and not fall under your definition of a medical device?

[800] So then the FDA doesn't have to be the ones authorizing it as a public health tool.

[801] And Sima Verma says, oh, well, we don't, we don't have any jurisdiction over point of care and sort of rapid devices like this.

[802] We only have jurisdiction over lab devices.

[803] So it's like nobody has ownership over it, which means that they just stay in this purgatory of not being approved.

[804] And so this is where I think, frankly, it needs a president.

[805] It needs a presidential order to just unlock them, to say, this is more important than having a prescription.

[806] And in fact, I mean, really what's happening now, because there is this sense that tests our public health tools, even if they're not being defined as such, The FDA now is pretty much, not only are they not authorizing these as public health tools, what they're doing by authorizing what are effectively public health tools as medical devices, they're just diluting down the practice of medicine.

[807] Right.

[808] I mean, his answer right now, unfortunately, is, well, I don't know why you want these to be sort of available to everyone without a prescription.

[809] We've already said that a doctor can write a whole prescription for a whole college campus.

[810] it's like, well, if you're going in that direction, then that's no longer medicine.

[811] Having a doctor write a prescription for a college campus, for everyone on the campus to have repeat testing, now we're just in the territory of eroding medicine and eroding all of the legal rules and reasons that we have prescriptions in the first place.

[812] So it's just everything about it is just destructive instead of just making a simple solution, which is these are okay as public health tools, as long as they meet X and why metrics go and CDC can put their stamp of approval on them.

[813] Well, what do you think, sorry if I'm stuck on this, your mention of MIT and public health engineering, right?

[814] I mean, it has a sense of, I talk to competition biology folks.

[815] It's always exciting to see computer scientists start entering the space of biology, and there's actually a lot of exciting things that happened because of that, trying to understand the fundamentals of biology.

[816] So from the engineering approach to public health, what kind of problems do you think can be tackled?

[817] What kind of disciplines are involved?

[818] Do you have ideas in this space?

[819] Oh, yeah.

[820] I mean, I can speak to one of the major activities that I want to do.

[821] So what I normally do in my research lab is develop technologies that can take a drop of somebody's blood or some saliva and profile for hundreds of thousands of different antibodies against every single pathogen that somebody could be possibly exposed to.

[822] That's awesome.

[823] So this is all new technology that we've been developing more from a, from a bioengineering perspective.

[824] But then I use a lot of the mathematics tools to A -interpret that.

[825] But what I really want to do, for example, to kind of kick off this new field of what I consider public health engineering is to create, maybe it's a little ambitious, but create a weather system for viruses.

[826] I want us to be able to open up our iPhones, plug in our zip code, and get a better sense, get a probability of why my kid has a runny nose today.

[827] Is it COVID?

[828] Is it a rhinovirus, or is it flu?

[829] And, you know, we can do that.

[830] We can start building the rules of virus spread across the globe, both for pandemic preparedness, but also for just everyday use.

[831] In the same way that people used to think that predicting the weather was going to be impossible.

[832] Of course, we know that's not impossible now.

[833] Is it always perfect?

[834] No, but does it offer, does it, you know, completely change the way that we go about our days?

[835] Absolutely.

[836] You know, I envision, for example, right now, we open up our iPhone, we plug in a zip code, and if it tells us it's going to rain today, we bring an umbrella.

[837] So, you know, in the future, it tells us, hey, you know, there's a lot of SARS -CoV -2 in your community, instead of grabbing your umbrella, you grab your mask.

[838] You know, we don't have to have masks all the time.

[839] But if we know the rules of the game that these viruses play by, we can start preparing for those.

[840] And, you know, every year we go into every flu season, blindfolded with our hands tied behind our back, just saying, I hope this isn't a bad flu season this year.

[841] I don't, I mean, this is, you know, we're in the 21st century.

[842] you know, it's becoming, you know, I mean, we have the tools at our disposal now to not have that attitude.

[843] This isn't like 1920s.

[844] You know, we can, we can just say, hey, this is going to be a bad flu season this year.

[845] Let's act accordingly and with a targeted approach.

[846] Now, we don't, for example, we don't just use our umbrellas all day long every single day in case it might rain.

[847] We don't board up our homes every single day in cases a hurricane.

[848] We wait and if we know that there's one coming, then we act for a small period of time accordingly.

[849] And then we go back and we've prepared ourselves in like these little bursts to not have it ruin our days.

[850] I can't tell you how exciting that vision of the future is.

[851] I think that's incredible.

[852] And it seems like it should be within our reach.

[853] Just these like weather maps of viruses floating about the earth and And it seems obvious.

[854] It's one of those things where right now it seems like maybe impossible.

[855] And then looking back like 20 years from now, we'll wonder like why the hell this hasn't been done away earlier.

[856] Though one difference in weather, I don't know if you have interesting ideas in the space, the difference in weather and viruses is it includes, the collection of the data includes the human body.

[857] potentially and that means that there is some as with the contact tracing question there's some concern about privacy this seems to be this dance that's really complicated you know with Facebook getting a lot of flack for basically misusing people's data or you know just whether there's perception or reality there's certainly a lot of reality to it too where they're not good stewards of our private data.

[858] So there's this weird place where it's like obvious that if we do, if we collect a lot of data about human beings and maintain privacy and maintain all like basic respect for that data, just like honestly common sense respect to the data, that we can do a lot of amazing things for the world, like a weather map for viruses.

[859] Is there a way forward?

[860] to gain trust of people, or to do this, to do this well?

[861] Do you have ideas here?

[862] How big is this problem?

[863] I think it's a central problem.

[864] There's a couple central problems that need to be solved.

[865] One, how do you get all the samples?

[866] That's not actually too difficult.

[867] I have a pilot project going right now with getting samples from across all the United States.

[868] Tens of thousands of samples every week are flowing into my lab and we process them.

[869] So it's taking the, it's taking like one of the, basically, this biology here in chemistry and converting that into numbers.

[870] That's exactly right.

[871] So what we're doing, for example, there's a lot of people who go to the hospital every day, a lot of people who donate blood, people who donate plasma.

[872] So one of the projects that I have, I'll get to the privacy question a moment, but this, so what I want to do is the name that I've given this is a global immunological observatory.

[873] You know, there's no reason not to have that.

[874] Good name.

[875] I've said, you know, instead of saying, well, how do we possibly get enough people on board to send in samples all the time?

[876] Well, just go to the source.

[877] You know, so there's a company in Massachusetts that makes 80 % of all the instruments that are used globally to, to collect plasma from plasma donors.

[878] So I went to this company of Hemenetics and said, you know, is there a way, you have 80 % of the global market on plasma donations.

[879] Can we, we start getting plasma samples from healthy people that use your machines.

[880] So that hooked me up with this company called Octafarma.

[881] And Octafarma has a huge reach and offices all over the country where they're just collecting people's plasma.

[882] They actually pay people for their plasma.

[883] And then that gets distributed to hospitals and all the stuff is anonymous plasma.

[884] So I've just been collecting anonymous samples.

[885] And we're processing them, in this case for COVID antibodies to watch from January, up through December, we're able to watch how the virus entered into the United States and how it's transmitting every day, you know, across the U .S. So we're getting those results organized now and we're going to start putting them publicly online soon to start making at least a very rough map of COVID.

[886] But that's the type of thinking that I have in terms of like, how do you actually capture huge numbers of specimens?

[887] You can't, ask everyone to participate on sort of a, I mean, you maybe could if you have the right tools and you can offer individuals something in return like 23 and Me does.

[888] You know, that's a great way to get people to give specimens and they get results back.

[889] So with these technologies that I've been building, along with some collaborators at Harvard, we can come up with tools that people might actually want.

[890] So I can offer you your immunological history.

[891] I can say, give me a drop of your blood on a filter paper, mail it in, and I will be able to tell you every infectious disease you've ever encountered, and maybe even when you encountered it roughly.

[892] I could tell you, do you have COVID antibodies right now?

[893] Do you have Lyme disease antibodies right now?

[894] Flu, Tripoli, and all these different viruses, also peanut allergies, you know, milk allergies, anything.

[895] You know, if your immune system makes a response to it, we can detect that response.

[896] So all of a sudden we have this very valuable technology that on the one hand gives people maybe information they might want to know about themselves, but on the other hand becomes this amazingly rich source of big data to enter into this global immunological observatory sort of mathematical framework to start building these maps, these epidemiological tools.

[897] But you ask about privacy.

[898] And absolutely that's essential to keep in mind first and foremost.

[899] So privacy can be, you can keep these samples 100 % anonymous.

[900] They're just, when I get them, they show up with nothing.

[901] They're literally just tubes.

[902] I know a date that they were collected and a zip code that they're collected from or, or even just sort of a county level ID.

[903] With an IRB and with ethical approval and with the people's consent, we can maybe collect more data, but that would require consent.

[904] But then there's this other approach, which I'm really excited about, which is.

[905] certainly going to gain some scrutiny, I think, but we'll have to figure out where it comes into play.

[906] But I've been recognizing that we can take somebody's immunological profile, and we can make a biological fingerprint out of it.

[907] And it's actually stable enough so that I could take your blood.

[908] Let's say I don't know who you are, but you sent me a drop of blood a year ago, and then you sent me a drop of blood today.

[909] I don't know that those two blood spots are coming from the same person.

[910] they're just showing up in my lab.

[911] But I can run our technology over that, and it just gives me your immunological history, but your immunological history is so unique to you and the way that your body responds to these pathogens is so unique to you that I can use that to tether your two samples.

[912] I don't know who you are.

[913] I know nothing about you.

[914] I only know when those samples came out of a person, but I can say, oh, these two samples a year apart actually belong to the same person.

[915] Yeah, so there's sufficient information that immunological history to match the samples.

[916] Or from a privacy perspective, that's really exciting.

[917] Is that generally hold for humans?

[918] So you're saying there's enough uniqueness to match?

[919] Yeah, because it's very stochastic, even twins.

[920] So this, I believe, you know, we haven't published this yet.

[921] We will soon.

[922] You have a twin, too, right?

[923] I do have a twin.

[924] I have an identical twin brother, which makes me interested in this.

[925] He looks very much like me. Oh, is that how that works?

[926] and you know DNA can't really tell us apart but this tool is one of the only tools in the world that could tell twins apart from each other could still be accurate enough to say this blood you know it's like 99 .999 % accurate to say that these two blood samples came from the same individual and it's because it's a combination both of your immunological history but also how your unique body responds to a pathogen, which is random.

[927] The way that we make antibodies is, by and large, it's got an element of randomness to it, how the cells, when they make an antibody, they chop up the genetic code to say, okay, this is the antibody that I'm going to form for this pathogen.

[928] And you might form, if you get a coronavirus, for example, you might form hundreds of different antibodies, not just one antibody against the spike protein, but hundreds of different antibodies against all different parts of the virus.

[929] So that gives this really rich resolution of information that when I then do the same thing across hundreds of different pathogens, some of which you've seen, some of which you haven't, it gives you an exceedingly unique fingerprint that is sufficiently stable over years and years and years to essentially give you a barcode, you know, and I don't have to know who you are, but I can know that these two specimens came from the same person somewhere out in the world so fascinating that there's this trace your life story in the space of viruses in the space of uh pathogens like like these or you know because there's this entire universe of these organisms that are trying to destroy each other and then your little trajectory through that space leaves a trace yep and then you can look at that trace.

[930] That's fascinating.

[931] And that, I mean, there's, okay, that data period is just fascinating.

[932] And the vision of making that data universally connected to where you can make, like, infer things and just like with the weather is really fascinating.

[933] And there's probably artificial intelligence applications there, start making predictions, start finding patterns.

[934] Exactly.

[935] We're doing a lot of that already.

[936] And that's how, how do we have this going?

[937] You know, I've been trying to get this funded for years now.

[938] And I've spoken to governments.

[939] You know, everyone says, cool idea.

[940] I'm not going to do it.

[941] You know, why do we need it?

[942] Oh, really?

[943] The why do you need it?

[944] The why do you need it?

[945] And of course, now, you know, I mean, I wrote in 2015 about this, why we would, why this would be useful.

[946] And of course, now we're seeing why it would be useful.

[947] Had we had this up and running in 2019, had we had it going.

[948] We were drawing blood from, you know, or getting blood samples from hospitals and clinics and blood donors from New York City, let's just say.

[949] You know, that could have, we didn't run the first PCR test for coronavirus until probably a month and a half or two months after the virus started transmitting in New York City.

[950] So it's like with the rain, we didn't start wearing umbrella or taken out umbrellas.

[951] Exactly, for two months.

[952] But different than the rain, we couldn't actually see that was spreading, you know.

[953] And so Andrew Cuomo had no choice but to leave the city open.

[954] You know, there were hints that maybe the virus was spreading in New York City, but, you know, he didn't have any data to back it up.

[955] No data.

[956] And so it was just week on week and week.

[957] And he didn't have any information to really go by to allow him to have the firepower to say, we're closing down the city.

[958] This is an emergency.

[959] We have to stop spread before it starts.

[960] And so they weigh it until the first PCR tests were coming about.

[961] And then the moment they started running a PCR test, they find out it's everywhere.

[962] And so that was a disaster because, of course, New York City, you know, it was just hit so bad because nobody was, you know, we were blind to it.

[963] We didn't have to be blind to it.

[964] And the nice thing about this technology is we wouldn't have, with the exact same technology we had in 2017, we could have detected this novel coronavirus spreading in New York city in 2020, not because we changed, not because we are actually actively looking for this novel coronavirus, but because we would see, we would have seen patterns in people's immune responses using AI or just frankly using our, just the raw data itself.

[965] We could have said, hey, it looks like there's something that looks like known coronavirus is spreading in New York, but there's gaps.

[966] You know, there's, for some reason, people aren't developing an immune response to this coronavirus that seems to be spreading to these normal things.

[967] that, you know, and it just looks, the profile looks different.

[968] And we could have seen that.

[969] And immediately, especially since we had an idea that there was a novel coronavirus circulating in the world, we could have very quickly and easily seen, hey, clearly we're seeing a spike of something that looks like a known coronavirus, but people are responding weirdly to it.

[970] Our AI algorithms would have picked it up.

[971] And just our basic, heck, you could put, you could have put it in an Excel spreadsheet we would have seen it.

[972] Some basic visualization would have shown it.

[973] We would have seen spikes and they would have been kind of like off, you know, immune responses that the shape of them just looked a little bit different, but they would have been growing and we would have seen it.

[974] And it could have saved tens of thousands of lives in New York City.

[975] So to me, the fascinating question, everything we've talked about, so both the huge collection of data at scale, just super exciting.

[976] and then the kind of obvious at -scale solution to the current virus and future ones is the rapid testing.

[977] Can we talk about the future of viruses that might be threatening our very existence?

[978] So do you think like a future natural virus can have an order of magnitude greater, effect on human civilization than anything we've ever seen.

[979] So something that either kills all humans or kills, I don't know, 60, 70 % of humans.

[980] So something we can't even imagine.

[981] Is that something that you think is possible?

[982] Because it seems to have not happened yet.

[983] So maybe like the entirety, whoever the programmer is of the simulation, that sort of launched the evolution for the Big Bang, seems to not want to destroy us humans.

[984] Or maybe that's a natural side effect in the evolutionary process that humans are useful.

[985] But do you think it's possible that the evolutionary process will produce a virus that will kill all humans?

[986] I think it could.

[987] I don't think it's likely.

[988] And the reason I don't think it's likely is, well, on the one hand, it hasn't happened yet, in part because mobility is, is a recent phenomena.

[989] People weren't particularly mobile until fairly recently.

[990] Now, of course, now that we have people flying back and forth across the globe all the time, the chances of global pandemics has escalated exponentially, of course.

[991] And so on the one hand, that's part of why it hasn't happened yet.

[992] We can look at things like Ebola.

[993] Now, Ebola, we don't, we haven't generally had major Ebola epidemics in the past, not because Ebola wasn't transmitting and infecting humans, but because they were, it was largely affecting and infecting humans in disconnected communities.

[994] So you see out in rural parts of Africa, for example, in Western Africa, you might end up having isolated Ebola outbreaks, but there weren't connections that were fast enough that would allow people to then spread it into the cities.

[995] Of course, we saw back in 2014 -15 a massive Ebola outbreak that wasn't because it was a new strain of Ebola, but it was because there's new inroads and connections between the communities and people got it to the city.

[996] And so we saw it start to spread.

[997] So that should be a little bit foreshadowing of what's to come.

[998] And now we have this pandemic.

[999] We had 2009.

[1000] We have this.

[1001] There is a benefit.

[1002] Or there is sort of a natural check.

[1003] And this is like kind of Latco -Volterre, predator prey dynamic kind of systems, ecological systems and mathematics that if you have something that's so deadly, people will respond more, maybe with a greater panic, A greater sense of panic, which alone could, you know, destroy humanity.

[1004] But at the same time, like, we now know that we can lock down.

[1005] We know that that's possible.

[1006] And so if this was a worse virus that was actually killing 60 % of people who was infecting, we would lock down very quickly.

[1007] My biggest fear, though, is let's say that was happening.

[1008] You need serious lockdowns if you're going to keep things going.

[1009] So the only reason we were able to keep things going during our lockdowns is because it wasn't so bad that we were still able to have people work in the grocery stores, still have people work in the shipping to get the food onto the shelves.

[1010] So on the one hand, we could probably figure how to stop the virus, but can we stop the virus without starving?

[1011] I'm not sure that that, if this was another acute respiratory virus that say it had a slightly, say it transmitted the same way, but say it actually did worse damage to your heart, but it was like a month later that people start having heart attacks.

[1012] in mass. It's like not just one -offs, but really severe.

[1013] Well, that could be a serious problem for humanity.

[1014] So in some ways, I think that there are lots of ways that we could end up dying at the hand of a virus.

[1015] I mean, we're already seeing it.

[1016] Just, I mean, my fear is still, I think coronaviruses have demonstrated a keen ability to destroy or to create outbreaks that can potentially be deadly to large numbers of people.

[1017] Flu strains, though, are still, by and large, my concern.

[1018] So you think the bad one might come from the flu, the influenza?

[1019] Yeah, the replication cycle, they're able to genetically recombine in a way that coronaviruses aren't.

[1020] They have segmented genomes, which means that they can just swap out whole parts of their genomes, no problem, repackage them, and then boom, you have a whole antigenic shift, not adrift.

[1021] What that means is that on any occasion, any day of the year, you can have, boom, a new, whole new virus that didn't exist yesterday.

[1022] And now with farming and industrial livestock, we're seeing animals and humans come into contact much more.

[1023] Just the opportunities for an influenza strain that is unique and deadly to humans increases, all the while transmission and mobility has increased.

[1024] It's just a matter a time in my opinion.

[1025] What about from immunology perspective of the idea of engineering a virus?

[1026] So not just the virus leaking from a lab or something, but actually being able to understand the protein, like everything about what makes a virus enough to be able to figure out ways to maybe targeted or untargeted attack.

[1027] biologists.

[1028] Suburtonity.

[1029] Yeah.

[1030] Is that something, obviously that's somewhere on the list of concerns, but is that anywhere close of the top ten highlights along with nuclear weapons and so on that we should be worried about, or is the natural pandemic the really the one that's much greater concern?

[1031] I would say that the former, that man -made viruses and genetically engineered, viruses should be right up there with the greatest concerns for humanity right now.

[1032] You know, we know that the tools, for better or worse, the tools for creating a virus are there, you know, we can do it.

[1033] I mean, heck, you know, the human species is no longer vaccinated against smallpox.

[1034] I didn't get a smallpox vaccine.

[1035] You didn't get a smallpox wanted to make smallpox and distribute it to the world in some way, it could be exceedingly deadly and detrimental to humans.

[1036] And that's not even sort of using your imagination to create a new virus.

[1037] That's one that we already have.

[1038] Unlike the past, when smallpox would circulate, you had large fractions of the community that was already immune to it.

[1039] And so it wouldn't spread or it would spread a little bit slower, but now we have, essentially, in a few years, we'll have a whole global population that is susceptible.

[1040] Let's look at measles.

[1041] We have an entire, I mean, measles, I have, you know, there are some researchers in the world right now, which for various reasons, are working on creating a measles strain that evades immunity.

[1042] It's not for bioterrorism.

[1043] At least that's not the expectation.

[1044] It's for using measles as an oncolic virus to kill cancer.

[1045] And the only way you can really do that is if your immune system doesn't, you know, if you take a measles virus and there's, you know, we don't have to go into the details of why it would work, but it could work.

[1046] Measles likes to target potentially cancer cells.

[1047] But to get your immune system, not to kill off the virus if you're trying to use the virus to target it, you maybe want to make it blind to the immune system.

[1048] But now imagine we took some virus like measles, which has an R -Nod of 18, transmits extremely quickly.

[1049] and now we have essentially, let's say we had a whole human race that is susceptible to measles.

[1050] And this is a virus that spreads orders of magnitude easier than this current virus.

[1051] Imagine if you were to plug something toxic or detrimental into that virus and release it to the world.

[1052] So it's possible to be both accidental and intentional.

[1053] Absolutely.

[1054] Yeah, so Mark Lipsitch, who's a good colleague of mine at Harvard, we're both in the he's the director of the Center for Communicable Disease Dynamics from a faculty member he's spoken very very forcefully and and uh and he's very outspoken about the dangers of gain of function testing where in the lab we are intentionally creating viruses that are exceedingly deadly under the auspices of trying to learn about them so that if the idea is that if we kind of accelerate evolution and make these really deadly viruses in the lab, we can be prepared for if that virus ever comes about naturally or through unnatural means.

[1055] The concern, though, is, okay, that that's one thing, but what if that virus got out on somebody's shoe?

[1056] Just what if?

[1057] You know, if the, if the, if the effects of an accident are potentially catastrophic, is it worth taking the chances just to be prepared a little bit for something that may or may not ever actually develop.

[1058] And so it's a serious ethical quandary we're in, how to both be prepared, but also not cause a catastrophic mistake.

[1059] As a small tangent, there's a recent really exciting breakthrough of Alpha II, of Alpha Fold 2 solving protein folding or achieving state -of -of -the -art performance on protein folding.

[1060] And then I thought proteins have a lot to do with viruses.

[1061] It seems like being able to use machine learning to design proteins that achieve certain kinds of functions will naturally allow you to use maybe down the line, not yet, but allow you to use machine learning to design basically viruses, maybe like measles for good, which is like to, attack cancer cells but also for bad is that is that uh is that a is that a crazy thought or is this a natural place where this technology may go i suppose is all technologies can which is for good and for bad do you think about the role of machine learning in this oh yeah absolutely i mean alpha fold uh is amazing you know it's an amazing algorithm uh series of algorithms.

[1062] And it does demonstrate, to me, it demonstrates just how powerful, you know, everything in the world has rules.

[1063] We just don't know the rules.

[1064] You know, we often don't know them.

[1065] But, you know, our brain has rules, how it works.

[1066] Everything is plus and minus.

[1067] There's nothing in the world that's really not at its most basic level, positive, negative.

[1068] You know, it's all, obviously, it's all just charge.

[1069] And that means everything, you can figure it out with enough computational power and enough.

[1070] In this case, I mean, machine learning and AI is just one way to learn rules.

[1071] It's an empirical way to learn rules, but it's a profoundly powerful way.

[1072] And certainly, now that we are getting to a point where we can take a protein and know how it folds, given its sequence, we can reverse engineer that, and we can say, okay, we want a protein to fold this way, what is the sequence need to be?

[1073] We haven't done that yet so much, but it's just the next iteration of all of this.

[1074] So let's say somebody wants to develop a virus, it's going to start with somebody wanting to develop a virus to defeat cancer, something good, you know, and so it will start with a lot of money from the federal government, you know, for all the positives that will come out of it.

[1075] but we have to be really careful because that will come about.

[1076] There's no doubt in my mind that we will develop.

[1077] We're already doing it.

[1078] We engineer molecules all the time for specific uses.

[1079] Oftentimes we take them from nature and then tweak them.

[1080] But now we can supercharge it.

[1081] We can accelerate the pace of discovery.

[1082] To not have it just be discovery, we have it be true ground -up engineering.

[1083] Let's say you're trying to make a new molecule to stabilize somebody with some retinal disease, right?

[1084] So we come up with some molecule that can improve the stability of somebody with retinal degeneration.

[1085] You know, just a small tweak to that to say make a virus that causes the human race to become blind, you know.

[1086] I mean, it sounds really conspiracy theoryish, but it's not.

[1087] We're learning so much about biology, and there's always nefarious reasons.

[1088] I mean, heck, look at how AI and, you know, just Google searches, those can be, you know, they are every single day being leveraged by nefarious actors to take advantage of people, to steal money, to do whatever it might be, eventually, probably to create wars, or already to create wars.

[1089] And, I mean, I don't think there's any question at this point behind disinformation campaigns.

[1090] And so it's being leveraged.

[1091] This thing that could be wholly good is always going to be leveraged for bad.

[1092] And so how do you balance that as a species?

[1093] I'm not quite sure.

[1094] The hope is, as you mentioned previously, that there's some that we were able to also develop defense mechanisms.

[1095] And there's something about the human species that seems to keep coming up with, like, ways to just, just like on the deadline, just at the last moment of figuring out how to avoid.

[1096] destruction.

[1097] I think I'm like eternally optimistic about the human race not destroying ourselves, but you could do a lot of things that would be very painful.

[1098] Yes.

[1099] Well, we're doing it already.

[1100] You know, just, I mean, we are seeing how our regulation today.

[1101] Right.

[1102] We did this thing.

[1103] It started as a good thing, regulation of medical products.

[1104] But now it is, you know, unwillingly and unintentionally harming us.

[1105] Our regulatory landscape, which was developed wholly for good in our country, is getting in the way of us, deploying a tool that could stop our economies from having to be sort of sputteringly closed that could stop deaths from happening at the rate that they are.

[1106] And it's, you know, I think we will come to a solution.

[1107] Of course, now we're going to get the vaccine and it's going to make people lose track of like why we even bother testing, which is a bad idea.

[1108] But we're already seeing that we have this amazing capacity to both do damage when we don't intend to do damage and then also to pull up when we need to pull up and, you know, stop complete catastrophe.

[1109] And so we are an interesting species in that way, that's for sure.

[1110] So there's a lot of young folks undergrads, grads, they're also young, listen to this.

[1111] So is there, you've talked about a lot of fascinating stuff that's like there's ways that things are done and there's actual solutions and they're not always like intersecting.

[1112] Do you have a device for undergraduate students or graduate students or even people in high school now about a life, about career of how they might be able to solve real big problems?

[1113] in the world, how they should live their life in order to have a chance to solve big problems in the world?

[1114] It's hard.

[1115] I struggle a little bit sometimes to give advice because the advice that I give from my own personal experience is necessarily distinct from the advice that would make other people successful.

[1116] I have unending ambitions to make things better, I suppose, and I don't see, I don't see barricades where other people sometimes see barricades.

[1117] Now, even just little things.

[1118] Like, when this virus started, I'm a medical director at Brighamow Women's Hospital, and so I oversee or help to oversee molecular virology diagnostics.

[1119] So when this virus started, wearing my epidemiology hat and wearing my sort of viral outbreak hat, I recognize that this is going to be a big virus that was important at a global level, even if the CDC and WHO weren't ready to admit that it was a pandemic.

[1120] It was obvious in January that it was a pandemic.

[1121] So I started trying to get a test built at the Brigham, which is one of Harvard's teaching hospitals.

[1122] You know, the first encounters I had with the upper administration of the hospital were pretty much no, why would we do that?

[1123] That's silly.

[1124] Who are you?

[1125] You know, and I said, well, okay, don't believe me, sure.

[1126] But I kept pushing on it.

[1127] And then eventually I got them to agree.

[1128] It was really only a couple of weeks before the biogen conference happened.

[1129] We started building the test.

[1130] I think they started looking abroad and saying, okay, this is happening, sure.

[1131] Like, maybe he was right.

[1132] But then I went a step further, and I said, we're not going to have enough tests at the hospital.

[1133] And so my ambition was to get a better testing program started.

[1134] And so I figured, what better place to scale up testing than the Broad Institute?

[1135] Broad Institute's is amazing, you know, very high throughput, high efficiency, research institute that does a lot of genomic sequencing, things like that.

[1136] So I went to the road and I said, hey, you know, there's this coronavirus that's obviously going to impact our society greatly.

[1137] Can we start modifying your high -efficiency instruments and robots for coronavirus testing?

[1138] Everyone in my orbit in the hospital world just said, that's ridiculous.

[1139] You know, how could you possibly plan to do that?

[1140] It's impossible.

[1141] You know, and to me it was like the most dead simple thing to do.

[1142] It didn't, but the higher ups and the people who think about, you know, I think one of the most important things is to recognize that most people in the world don't see solutions.

[1143] They just see problems.

[1144] And it's because it's an easy thing to do.

[1145] Thinking of problems and how things will go wrong is really easy because you're not coming up with a brand new solution.

[1146] And this to me was just a super simple solution.

[1147] Hey, let's get the brood to help build tests.

[1148] Every single hospital director, you know, told me no, like it's important.

[1149] possible.

[1150] My own superior is the ones I report to in the hospital, said, you know, Mike, you're a new faculty member.

[1151] Your ideas, you know, probably will, would be right, but you're too naive and young to know that it's impossible.

[1152] Right.

[1153] You know, obviously now the broad is, is the highest throughput laboratory in the country.

[1154] And, you know, and so I think my recommendation to people is as much as possible, get out of the mode of thinking about things as problems.

[1155] Sometimes, you piss people off, I could probably use a better filter sometimes to try to like be not so upfront with certain things, but, but it's just so crucial to always just see, to just bring, like think, think about things in new ways that other people haven't, because usually there's something else out there.

[1156] And one of the things that has been most beneficial to me, which is that my, my education was really broad.

[1157] It was engineering and physics.

[1158] And, well, and then I became a Buddhist monk for a while.

[1159] And so that gave me a different perspective.

[1160] But then it was medicine and immunology.

[1161] And now I've brought all of it together from a mathematics and biology and medicine perspective and policy and public health.

[1162] And I think that, you know, I'm not the best in any one of these things.

[1163] I recognize that there are going to be geniuses out there who are just worlds better than me at any one of these things that I try to work on.

[1164] But my superpower is bringing them all together, You know, and just thinking, and that's, I think, how you can really change the world.

[1165] You know, I don't know that I'll ever change the world in the way that I hope.

[1166] But that's how you can have a chance.

[1167] Yeah, that's how you can have a chance, exactly.

[1168] And I think it's also what, you know, this, to me, this rapid testing program, like, this is the most dead simple solution in the world.

[1169] And this literally could change the world, actually.

[1170] It could change the world.

[1171] It could change.

[1172] And it is.

[1173] You know, there's countries that are doing it now.

[1174] The U .S. isn't, but I've been advising many countries on it.

[1175] And I would say that, you know, some of the early papers that we put out earlier on, a lot of the things actually are changing, you don't always, unless you really look hard, you don't know where you're actually having an effect.

[1176] Sometimes it's more overt than other times.

[1177] In April, I published a paper that was saying, hey, with the PCR values from these tests, we need to really focus on the CT values, the actual quantitative values of these lab -based PCR tests.

[1178] At the time, all the physicians and laboratory directors told me that was stupid.

[1179] You know, why would you do that?

[1180] They're not accurate enough.

[1181] And, of course, now it's headline news that, you know, Florida, they just mandated reporting out the CT valleys of these tests.

[1182] Because there's a real utility of them.

[1183] You can understand public health from it.

[1184] You can understand better clinical management.

[1185] You know, that was a simple solution to a pretty difficult problem.

[1186] And it is changing the way that we approach all of the way.

[1187] the lab testing in this country is starting to, it's taken a few months, but it's starting to change because of that.

[1188] And, you know, that was just me saying, hey, this is something we should be focusing on.

[1189] Got some other people involved and other people, and now people recognize, hey, there's actual value in this number that comes out of these lab -based PCR tests.

[1190] So sometimes it does grow fairly quickly.

[1191] But I think the real answer, my only answer, I don't know what, you know, recognize that everyone, some people are going to be really focused on and have one small but deep skill set.

[1192] I go the opposite direction.

[1193] I try to bring things together.

[1194] But the biggest thing I think is just don't see barriers.

[1195] Like just see, like there's always a solution to a barrier.

[1196] If there's a barrier that literally means a solution to it, that's why it's called a barrier.

[1197] And just like you said, most people will just present to you, only be thinking about it and present to you with barriers.

[1198] And so it's easy to start thinking that's all there is in this world.

[1199] Yeah.

[1200] And just think big.

[1201] I mean, God, you know, there's nothing wrong with thinking big.

[1202] Elon Musk thought big and, you know, and then thinking big builds on itself.

[1203] You know, you, you get a billion dollars from one big idea, and then that allows you to make three new big ideas.

[1204] And there's a hunger for it.

[1205] If you think big and you communicate that vision with the world, all the most brilliant and, like, passionate people will just, like, you'll attract them.

[1206] and they'll come to you, and then it makes your life actually really exciting.

[1207] The people I've met at, like, Tesla and NeuroLink, I mean, there's just like this fire in their eyes.

[1208] They just love life, and it's amazing, I think, to be around those people.

[1209] I have to ask you about what was the philosophy, the journey that took you to becoming a Buddhist monk, and what were, what did you learn about life?

[1210] what did you take away from that experience?

[1211] How did you return back to Harvard and the world that's unlike that experience, I imagine?

[1212] Yeah, well, I was at Dartmouth at the time.

[1213] Well, I went to Sri Lanka.

[1214] I was already pretty interested in developing countries and sort of under -resourced areas.

[1215] And I was doing a lot of engineering work, and I went there, but I was also starting to think maybe health was something of interest.

[1216] and so I went to Sri Lanka because I had a long interest in Buddhism as well just kind of interested in it as a thing which aspect of the philosophy attracted you I would say that the thing that interested me most was really this idea of kind of a butterfly effect of like you know what you do now has ripple effects that extend out beyond what you can possibly imagine, both in your own life and in other people's lives.

[1217] And in some ways, Buddhism has, not in some ways, in a pretty deep way, Buddhism has that as part of its underlying philosophy in terms of rebirth and sort of your actions today propagate to others, but also propagate to sort of what might happen in your circle of what's called samsara and rebirth.

[1218] And I don't, I don't know that I subscribe fully to this idea that we are reborn, which always was a little bit of a debate internally, I suppose, when I was a monk.

[1219] But it has always been, it was that, and then it was also meditation.

[1220] At the time, I was a fairly elite rower.

[1221] I was, you know, rowing at the national level.

[1222] And rowing to me was very meditative.

[1223] It was, you know, just there's, even if you're in a boat with other people, it's, I mean, on the one hand, it's like the extreme of like a team sport, but it's also the extreme sort of focus and concentration that requires, that's required of it.

[1224] And so I was always really into just meditative type of things.

[1225] He's doing a lot of pottery too, which was also very meditative.

[1226] And so Buddhism just kind of really, really, there are a lot of things about meditating that just appealed.

[1227] And so I moved to Israel.

[1228] Blanca, planning to only be there for a couple of months.

[1229] But then I was shadowing in this medical clinic, and there was this physician who was just really, I mean, it's just kind of a horrible situation, frankly, this guy was trained decades earlier, he was an older physician, and he was still just practicing like these fairly barbaric approaches to medicine because he had, you know, as a rural town, and he just didn't have a lot of, he didn't have any updated training, frankly.

[1230] And so, you know, I just remember this, like, girl came in with, like, shrapnel in her hand.

[1231] And his solution was to, like, air it out.

[1232] And so he was, like, without even numbing her hand, he was, like, cutting it open more with this idea that, like, the more oxygen and stuff, you know.

[1233] And it just, I think there was something about all of this.

[1234] And I was already talking to these monks at the time each, I would be in this clinic in the morning and I'd go.

[1235] and my idea was to teach English to these monks in the evening.

[1236] It turned out I'm a really bad English teacher.

[1237] So they just taught, they allowed me just to sit with them and meditate, and they were teaching me more about Buddhism than I could have possibly taught them about English or being an American or something.

[1238] And so I just slowly, I just couldn't take, I couldn't handle being in that clinic.

[1239] So more and more, I just started moving to, you know, spending more, and more time at this monastery.

[1240] And then after about two months, I was supposed to come back to the States, and I decided I didn't want to.

[1241] So I moved to this monastery in the mountains, primarily because I didn't have the money to, like, just keep living.

[1242] So living in a monastery is free.

[1243] Yeah.

[1244] And so I moved there and just sort of meditating more and more, and then months went by, and I, it just really gravitated.

[1245] I gravitated to the whole, to the whole notion of it.

[1246] I mean, it became, it sounds strange, but, you know, meditating almost, just like anything that you've put your mind to, became exciting, you know, it became, like, there weren't enough hours in the day to meditate.

[1247] And I would do it for, you know, 18 hours a day, 15 hours a day, just sit there, and you, and like, I mean, I hate sleeping anyway, but I wouldn't want to go to sleep because I felt like I didn't accomplish what I needed to accomplish in meditation that day, which is so because there is no end, you know, but it was always, but there are these, uh, there are these steps that happened during meditation that are very prescribed in a way.

[1248] Buddha talked about them, you know, and these are ancient writings, which exist.

[1249] I mean, the writings are real.

[1250] They're thousands of years old now.

[1251] And, um, you know, the, so whether it was Buddha writing them or whoever, you know, there are lots of different people who have contributed to the, to these writings over the years.

[1252] And, um, but they're very prescribed.

[1253] And they, um, they tell you what you're going to go through.

[1254] And I didn't really focus too much on them.

[1255] I read a little bit about them, but your mind really does when you actually start meditating at that level, like not an hour here and there, but like truly just spending your day as meditating.

[1256] It becomes kind of like this other world where it becomes exciting.

[1257] And you're actively working.

[1258] You're actively meditating, not just kind of trying to quiet things.

[1259] That's sort of just the first stage of trying to get your mind to focus.

[1260] Most people never get past that first stage, especially in our culture.

[1261] Could you briefly summarize what's waiting beyond the stage of just quieting the mind?

[1262] It's hard for me to imagine that there's something that can be described as exciting on there.

[1263] Yeah, it's an interesting question.

[1264] So I would say, so the first thing, the first step is truly just to like be able to close your eyes, focus on your breath and not have other things.

[1265] thoughts enter into your mind.

[1266] That alone is just so hard to do.

[1267] Like, I couldn't do it now if I wanted.

[1268] But I could then.

[1269] But once you get past that stage, you start entering into like all these other, you go through kind of, I went to this like pretty trippy stage, which is a little bit euphoric, where you just kind of start not hallucinating.

[1270] I mean, it wasn't like some you start getting into the stage where you're able to quiet your mind for so long for hours at a time that, like for me, I started getting really excited about this idea of mindfulness, which is part of Buddhism in general, but it's part of Tarvatum Buddhism in particular for this, in this way, which was, you take, you start focusing on your daily activities, whether that's sipping a cup of tea or walking.

[1271] or you know sweeping around I lived in on this mountain side in this cottage thing was built into the rock and you know so every morning I would wake up early and sweep around it and stuff because that's just what we did and you start to you meditate on all those activities and one of the things that was so exciting which sounds completely ridiculous now was just almost learning about your daily activities in ways that you you never would have thought about before.

[1272] So what is involved with, like, picking up this glass of water?

[1273] You know, if I said, okay, I'm just going to pick, I'm going to take a drink of water.

[1274] To me right now, it's a single activity, right?

[1275] You just, but during meditation, it's not a single activity.

[1276] It's a whole series of activities of, like, little engineering feats and feelings.

[1277] And it's gripping the water.

[1278] and it's feeling that the glass is cold and it's lifting and it's moving and dragging and dragging and you start to learn a whole new language of life and that to me was like this really exhilarating thing that it was an exhilarating component of meditation that there was never enough time it's kind of like learning a new computer language like it gets really exciting when you start coding and all these new things you can do you learn how to much to experience life in a much richer way, and so you never run out of ways to go deeper and deeper and deeper in the way you experience you and just the drinking of the glass of water.

[1279] That's exactly right.

[1280] And what becomes kind of exhilarating is you start to be able to predict things that you never are, I don't even have predictions, the right word.

[1281] But I always think of the Matrix, you know, where I forget who it was.

[1282] Somebody was shooting at Neo, and he like leans backwards and he dodges the bullets.

[1283] You know, in some ways when you start breaking every little action that your hands do or that your feet do or that your body does, down into all these little actions that make up one what we normally think of as an action, all of a sudden you can start to see things almost in slow motion.

[1284] I like to think of it very much like language.

[1285] The first time somebody hears a foreign language, it sounds really fast usually.

[1286] You don't hear the spaces between words.

[1287] And And it just sounds like just like a stream of conscious.

[1288] And it just sounds like a stream of noises if you've never heard the language before.

[1289] And as you learn the language, you hear clear breaks between words, and it starts to gain context.

[1290] And all of a sudden like that, what once sounded very fast slows down and it has meaning.

[1291] That's our whole life.

[1292] There's this whole language happening that we don't speak generally.

[1293] But if you start to speak it, and if you start to learn it, and you start to say, Hey, I'm picking up this glass is actually 18 little movements.

[1294] Then all of a sudden, like, it becomes extremely exciting and exhilarating to just breathe.

[1295] You know, breathing alone in the rise and fall of your abdomen or the way the air pushes in and out of your nose becomes almost interesting.

[1296] And what's really neat is the world just starts slowing down.

[1297] And I'll never forget that feeling.

[1298] And it's the, if there was one euphoric feeling from meditation, I want to gain back.

[1299] but I don't think I could without really meditating like that again and I don't think I will was this slow motion of the world it was finding the spaces between all the movements in the same way that the spaces between all the words happen and then it almost gives you this new appreciation for everything you know it was like it was really amazing and so I think it came to an abrupt end though when the tsunami hit I was there in the Indian Ocean tsunami hit in 2004 And it was like this dichotomy of being a monk and, you know, just meditating in this extraordinary place.

[1300] And then the tsunami hits and kills 40 ,000 people in a few minutes on the coast of this really small little country in Sri Lanka.

[1301] And, you know, then I, like my whole world of being a monk came crashing down when I go to the coast.

[1302] And I mean, that was just a devastating visual sight and emotional site.

[1303] But the strangest thing happened, which was that everyone just wanted me to stay as a monk.

[1304] You know, people in that culture, they wanted to, the monks largely fled from the coast lines.

[1305] Those, you know, and so then there I was, and people wanted me to be a monk.

[1306] They wanted me to stay on the coast, but be a monk and not help, like not help in the, in the way that I considered helping.

[1307] They wanted me just to keep meditating so they could bring me Donna, like offerings and have their sort of karmic responsibilities attended to as well.

[1308] And so that was really bizarre to me. It was like, how could I possibly just sit around while all these people, half of everyone's family just died.

[1309] And so in any case, I stopped being a monk and I moved to this refugee camp and lived there for another six months or so, and just stayed there, not as a monk, but tried to raise some money from the U .S. and tried to, like, I didn't know what I was doing, frankly, I was 22.

[1310] And I don't think I appreciated at the time how much of a role I was having in that community's life.

[1311] But it's taken me many years to process all of this since then, I would say it's what put me into the public health world, living in that refugee camp, and that difference that happened, you know, from being a monk to being in this devastating environment, just really changed my whole view of what, sort of why I was existing, I suppose.

[1312] Well, so there's this richness of life in a single drink of water that you experienced, and then there's this power, of nature that's capable to take lives of thousands of people.

[1313] So given all that, the absurdity of that, let me ask you, and the fact that you study things that could kill the entirety of human civilization, what do you think is the meaning of this all?

[1314] What do you think is the meaning of life, this whole orchestra we've got going on?

[1315] Does it have a meaning?

[1316] And maybe from another perspective is how does one live a meaningful life, if such as possible?

[1317] Well, you know, from what I've seen, I don't think there's a single answer to that by any stretch.

[1318] One of the most interesting things about Buddhism to me is that the human existence is part of suffering, which is very different from Judeo -Christian existence, which is that human existences, something to be, is a very different, you know, it's something to, there's a richness to it.

[1319] In Buddhism, it's just another one of your lives.

[1320] And it, but it's your opportunity to attain nirvana and become a monk, for example, and meditate to attain nirvana.

[1321] Else you kind of just go back into the samsar, the cycle of suffering.

[1322] And so, you know, when I look at, I mean, in some ways, the notion of life and what the purpose of life is, you know, they're kind of completely distinct, this sort of Western view of life, which is that this life is the most precious thing in the world versus this is just another opportunity to try to get out of life.

[1323] I mean, the whole notion of nirvana and in Buddhism at getting out of this sort of cycle of suffering is to vanish.

[1324] You know, if you could attain nirvana, you know, throughout this life, the idea is that you don't get reborn.

[1325] And so when I look at these two, you know, on the one hand, you have Christian, you know, Christian faith and other things that want to go to heaven and like live forever in heaven.

[1326] Then you have this other whole half of humans who want nothing more than to get out of the cycle, of rebirth and just poof, you know, not exist anymore.

[1327] The cycle of suffering.

[1328] Yeah, and so how do you reconcile those two?

[1329] And I guess...

[1330] Do you have both of them in you?

[1331] Do you basically oscillate back and forth?

[1332] I don't think I, I think I just, I look at us in a, I think we're just a bunch of proteins that, you know, we form and we, they work in this really amazing way.

[1333] And they might work in a bigger scale.

[1334] Like, there might be some connections that we're not really clear about, but they're still biological.

[1335] I believe that they're biological.

[1336] How do these proteins become conscious?

[1337] And why do they want to help civilization by having at home rapid tests at scale?

[1338] Well, I think, I don't have an answer to that one, but I really do believe that.

[1339] It's just, you know, this is just an evolution of consciousness.

[1340] I don't, I don't personally think is, my feeling is that we're a bunch of pluses and minuses.

[1341] have just gotten so complex that they're able to make rich feelings, rich emotions.

[1342] And I do believe, though, you know, on the one hand, I sometimes wake up some days.

[1343] My fiancé doesn't always love it, but, you know, I kind of think we're all just a bunch of robots with, like, pretty complicated algorithms that we deal with.

[1344] Yeah.

[1345] And, you know, in that sense, like, okay, if the world just blew up tomorrow and nothing was lived, you know, nothing existed the day after that.

[1346] it's just another blip in the universe you know but at the same time i don't know so that's kind of probably my most core basic feeling about life is like we're just a blip and we may as well make the most of it while we're here blipping it's it's one hell of a fun blip though it is it's an it's an amazing uh you know blink of a of an eye in time michael this is you're one of the most interesting people i've met one of the most interesting conversations important ones now.

[1347] I'm going to publish it very soon.

[1348] I really appreciate taking the time.

[1349] I know how busy you are.

[1350] It's really fun.

[1351] Thanks for talking today.

[1352] Well, thanks so much.

[1353] This was a lot of fun.

[1354] Thanks for listening to this conversation with Michael Minna.

[1355] And thank you to our sponsors.

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[1361] If you enjoy this thing, subscribe on YouTube, review it with five stars on Apple Podcast, follow on Spotify, support it on Patreon, or connect with me on Twitter at Lex Friedman.

[1362] And now, let me leave you with some words from Teddy Roosevelt.

[1363] it is not the critic who counts.

[1364] Not the man who points out how the strong man stumbles or where the doer of deeds could have done them better.

[1365] The credit belongs to the man who actually is in the arena, whose face is marred by dust and sweat and blood, who strives valiantly, who errs, who comes short again and again, because there is no effort without error and shortcoming, but who does actually strive to do the deed.

[1366] needs, who knows great enthusiasms, the great devotions, who spends himself in a worthy cause, who at the best knows in the end that triumph of high achievement, and who at the worst, if he fails, at least fails while daring greatly, so that his place shall never be with those cold and timid souls who neither know victory nor defeat.

[1367] Thank you for listening and hope to see you next time.