#1349 - David Sinclair

[0] David Sinclair Lifespan Why we age and why we don't have to I'm so happy there are people like you out there Because I don't want to age I'm aging clearly But I'm not interested in it I don't like it Yeah well I don't know anybody who does Joe Rogan thanks for having me back on Thanks for coming back The first one was a smash hit man People loved it All my friends were very excited But I had a question for you right off the bat regarding metformin there was actually an article i'm sure you saw it recently um like within the last couple of days that was going around through all the mainstream papers it was uh talking about how for the use of metformin uh dhia and was there something else as well that was taking two years human growth hormone taking two years two biological years off of people's lives in terms of their their age which are natural eight with your actual i'm 52 it would make me 50 Right, even 49 .5, according to the study.

[1] That's what I'm looking for.

[2] Yeah, that was a good study.

[3] You know, it's only nine people, so we have to repeat this.

[4] Were they studs?

[5] Did you get like nine super athletes, or did you get like schmows that don't exercise?

[6] As far as I know, these were just regular.

[7] Schmows?

[8] Schmose, yeah, which is good news for schmows like me. Yes, good news.

[9] Yeah, I mean, that's what you want.

[10] You don't want, like, some people just respond better.

[11] They have super bodies, you know?

[12] Well, the great thing about that study is, first of all, I was with the main author on that paper while it came out.

[13] I was over in Israel as part of my journey up, the Great Rift of Africa, ended up in Israel.

[14] Anyway, the guy there, Steve Horvath is his name.

[15] He and I and a couple of other guys are trying to figure out not just why we age, why we don't have to, but is aging truly reversible?

[16] And that's what this study suggests, is that it's not just about social.

[17] slowing down aging, but one day we could be 80, but biologically 30.

[18] Now, when we're talking about the biological age, how is that measured?

[19] Is this measured by the length of the telomeres?

[20] Is this measured by physical performance?

[21] Is it measured by a combination of these factors?

[22] It's none of that.

[23] It's something brand new.

[24] Most people don't know about it.

[25] So it's called the Horvath clock.

[26] And what Horvath and others have discovered is that if you read the DNA and you don't just look at the letters, a CTG, if you look at what's on the letter C, cytosine is called, there are chemical modifications, and those chemicals change as we get older in very linear and predictable ways.

[27] And if you use a computer, AI, you can say, if I took your blood sample right now, I could read your DNA, look at those chemical groups on the C's, and I could say, you are, okay, you're 52, you might be 46 according to that clock, and also I could predict when you're going to die.

[28] scary thought right yeah like a fortune teller yeah but the good news is well now that we know what's not just measuring aging we actually think that clock is part of the aging process we're learning how to reverse it too hmm now is this just one modality this this combination of growth hormone is this one way of going about it are there other ways of going about it growth hormone dhia metformin is there anything else well that's the first that It's ever been shown to really reverse, but I'm sure there's going to be many more discovered.

[29] We've only had this Hovath clock over the last few years in humans being used widely.

[30] But I think as we use this clock, we're going to figure out that a whole bunch of stuff that we do and things that we can do and combine will not just slow aging, but reverse it.

[31] And not just by two and a half years, eventually, and some of the technology that I talk about in my book, we think could turn the clock back by a decade or more.

[32] Whoa.

[33] Now, what things are you talking about that could possibly turn it back a decade or more?

[34] Well, so the...

[35] And who do I have to blow?

[36] Sorry.

[37] Yeah, you can blow me, but...

[38] Yeah, you may have to do it a few times.

[39] But the amazing thing about where we are now today with aging, and we're right on the cutting edge.

[40] So it's great to be able to share this with your listeners is this clock, it's changes on the DNA, right?

[41] Right.

[42] What I'm saying in my theory of aging is that it's not the DNA that we lose.

[43] That's the old theory.

[44] You know, the old idea that antioxidants hurt the DNA.

[45] Just throw that out for a while, maybe forever.

[46] What I think is going on is that the DNA is getting modified and the cell can't read the DNA the way it used to.

[47] Okay, that's really important.

[48] And so the clock is not just a clock.

[49] It's not a clock on the wall.

[50] It's also, if you move the hands of the clock, time changes.

[51] That's what I think is going on.

[52] Can we pause right here for a moment and explain what you were saying about antioxidants?

[53] Well, antioxidants have been the biggest disappointment.

[54] in the aging field.

[55] It doesn't stop 40 million people every day buying drinks with antioxidants in them, but antioxidants have, with very few exceptions, failed to extend the lifespan of any organism.

[56] But you are a proponent of resveratrol, at least you used to be.

[57] Are you still?

[58] I still take it.

[59] And we still study it in my lab.

[60] But what's, you brought this up, it's really important.

[61] Resveratrol was originally thought to be an antioxidant, and it is a mild antioxidant.

[62] But the way it really works, we know this is a fact from my lab, is that it's stimulating the body's defenses against aging and disease, because it's binding to these enzymes that we work on called Sertuans, and these are the defenders of the body.

[63] And you were saying if I remember correctly, you take resveratrol, you take a powdered form, actually bought exactly what you take, and you mix it with yogurt in the morning?

[64] Is that how you do it?

[65] Yep.

[66] What's the dose that you take?

[67] Well, it probably comes out to about a gram in the morning.

[68] A gram.

[69] Okay, so if someone's taking capsules, well, it depends.

[70] Probably capsules are 250 milligrams.

[71] That'd be four in the morning.

[72] Yeah, you know, I'm still alive, so that's, it's a good sign.

[73] Oh, thank you.

[74] Do you, um, is it important to take it with fats?

[75] Is that why you take it with yogurt?

[76] Yeah, yeah, either high protein, which is, you know, Greek yogurt suffices or fat.

[77] But water, it's like brick dust.

[78] It won't dissolve and it won't be absorbed.

[79] But a glass of whole milk maybe would be okay?

[80] Yeah, that's great.

[81] But it has to have something to bind to.

[82] Is that the deal?

[83] For sure.

[84] Yeah.

[85] In our studies, in humans and in mice, if we didn't give them high fat food, it barely got in.

[86] There was five -fold less.

[87] Now, this study of metformin, DHA, and human growth hormone does not include NMN.

[88] right so but nmn is also effective uh well let's delve in a little bit please if you read the paper uh and i i have uh turns out one of the effects of this treatment was the reduction in the levels of a protein called cd 38 cd 38 resides on immune cells and it goes up as we get older and what they found one of the biggest effects of the treatment was the levels of this cd 38 protein went down.

[89] So what is the CD -38?

[90] This is the main enzyme in our bodies that degrades NAD.

[91] NAD is required for the Sertouin defenders to work.

[92] So one possibility is that, and I'm sure it's complicated, but one way this could be working is by allowing your body to make NAD and store it rather than degrading it as we get older.

[93] Interesting.

[94] So would supplementing with NMN, which is a form of NAD, correct?

[95] A precursor, yeah.

[96] Precursor.

[97] Would that enhance the effects, do you believe?

[98] Like, if they tried to do a new study?

[99] It could.

[100] Could.

[101] It could.

[102] Potentially.

[103] Each of these patients cost $10 ,000 for the treatment, so it's not easy to do these studies.

[104] $10 ,000 for the entirety of the treatment and the treatment lasted?

[105] How long?

[106] I don't remember how long they treated the patients for.

[107] But I do know that it wasn't cheap.

[108] That's why they only did nine.

[109] At first I said to my friend, Steve Horvath, nine patients, are you kidding me?

[110] Why didn't you do 50?

[111] And I went, well, we didn't have the money.

[112] That's the problem.

[113] Anyway, my point really is that we need to test a lot of different combinations, include Anamand, include there's one called Rapamycin, which is a little bit more risky and toxic, but there are better molecules in development.

[114] The question is, what is the best combination?

[115] And do you use it with exercise and fasting?

[116] Or is it bad to combine them all together?

[117] We don't know yet.

[118] That's a good question, too, that I'm.

[119] wanted to ask you because one of the things that came out of the podcast was input from some other people that I know that are nutrition experts and performance experts that were skeptical about metformin.

[120] And they were saying that metformin, although it may have an anti -aging effect, it actually decreases physical performance in athletes.

[121] Well, there is a study that shows that and resveratrol too actually.

[122] Really?

[123] Can prevent the great gains from hard exercise.

[124] So here's the solution that I think is worth trying a solution.

[125] And that is a theme that I have in my book and in my research.

[126] And that is we don't want to be doing everything every day necessarily.

[127] We want to pulse it.

[128] We want to shock the body and let it recover.

[129] We know that you can't just exercise.

[130] I mean, some people have been on this show run 100 miles every weekend.

[131] But generally you want to hit it hard and let it recover, hit it hard to recover.

[132] So what I am planning to do, and actually started doing is on days that I'm exercising and recovering, I don't take metformin.

[133] And then when I'm just sitting around or on a plane, I do.

[134] And that way, I think that my body can have the best of both worlds.

[135] So when you are not exercising and you take it, you feel like it doesn't have a hit when you are exercising and not taking it?

[136] So somehow or another, whatever performance hit it has, it's temporary?

[137] Yeah, right.

[138] So well...

[139] This is all just theoretical.

[140] It is.

[141] We're right on the cutting edge of human knowledge.

[142] We don't actually know what the best thing is.

[143] But my, my best guess is that we want to allow the body to recover.

[144] So I don't take metformin on those days, rather than taking metformin every day like a diabetic would.

[145] Now, what is the, what's the hit?

[146] Like, what is happening?

[147] What's the mechanism behind the performance hit from taking metformin?

[148] Oh, we don't know.

[149] But I can tell you the best explanation that I can give you.

[150] So metformin is a derivative of a plant molecule, the French lilac, so it's not a crazy molecule.

[151] It's pretty natural.

[152] But what it does is many things in the body.

[153] Scientists will quite annoyingly argue about it for, they have for the past 40 years.

[154] So there's no correct answer, but what I think is going on is that metformin is interfering with the mitochondria, mitochondria in the cell.

[155] Miticondria, we call them battery packs.

[156] They're basically making chemical energy.

[157] Without that chemical energy, we'd be dead in about 20 seconds.

[158] So we need that for life.

[159] So metformin interrupts that energy production in the mitochondria, but you need the mitochondria to amplify after you've exercised.

[160] So they're antagonizing each other.

[161] So why does metformin work?

[162] By inhibiting the mitochondria, the body gets a signal that it doesn't have enough chemical energy.

[163] It's not making enough.

[164] So it expands the number of mitochondria.

[165] These are ancient remnants of bacteria that entered our cells.

[166] And we have less if we sit around, and like we are now.

[167] And we have more if we exercise.

[168] And metformin, by telling the body a shit we're running out of energy, the body responds and makes more mitochondria, just like exercise does.

[169] But I think if you're taking metformin and exercising, that inhibition is preventing the benefits somehow of what you get with exercise.

[170] Preventing it how so?

[171] Like what did the study, or what studies have been done, and what did they reveal?

[172] I don't remember the precise details of the study.

[173] It was giving metformin every day to people who were in a controlled exercise.

[174] I think it was treadmill a few times a week.

[175] But then what they measured was the mitochondrial benefit.

[176] And I think they measured a bit of strength.

[177] It's so confusing that there's a mitochondrial benefit, but a performance hit.

[178] Well, no, they actually, metformin prevented the mitochondria from amplifying up.

[179] Oh.

[180] All right.

[181] So it must be interfering.

[182] with the signal that you get from exercise, whatever that is.

[183] We don't know exactly what that is.

[184] So you'd really have to be some sort of a guinea pig to try to fuck with this stuff to go back and forth from taking it and exercising, not taking it, and exercising.

[185] I'm one of those guinea pigs.

[186] Yeah.

[187] And what do you, no disrespect, but how hard are you working out?

[188] Not enough.

[189] Yeah, that's what I'm saying.

[190] I spend three hours a week in the gym.

[191] That's not bad.

[192] It's all in one day.

[193] That's maintenance.

[194] Oh, one day?

[195] Really?

[196] One day, three hours?

[197] Yeah, that's it.

[198] Why are you doing it that way?

[199] Because I'm a smart.

[200] But you're so smart.

[201] That drives me crazy when smart people do dumb shit.

[202] Like I had Peter Hotez on the podcast, who's a brilliant man from the University of Texas.

[203] He's a researcher in tropical diseases and he's obsessed with diseases and the importance of vaccination, all these different things.

[204] Then he's talking about how his diet is terrible.

[205] He eats junk food.

[206] He's constantly eating jacking the box and shit.

[207] I'm like, what the fuck, man?

[208] You're so smart, and you're a guy who works on diseases.

[209] What's the number one cause of diseases?

[210] Yeah, I don't get that.

[211] Some of my colleagues eat the worst food, and they study longevity.

[212] Crazy.

[213] It's crazy.

[214] It's like they can't help their impulses.

[215] It's like there's so many people like that that are obsessed with various aspects of health or performance, but they just can't get it together.

[216] Well, I would work out more if I had time.

[217] I'm usually working until midnight, and after that I'm not really.

[218] can you go to the gym you do have an excuse you have a crazy work schedule you do have an excuse yeah well I'm on planes a bit so I try to exercise on the planes pretty hard do you really what you do you do you go to the bathroom you go to the bathroom squats so nobody thinks you crazy yeah he's got to pee a lot or you're doing blowing there or something yeah I've done exercise for a while people think you're in there doing meth yeah doing something in there squats yeah um so what do you do when you work out uh I lift waits for an hour, then do a fair bit of stretching, and then I actually do some hot and cold treatment.

[219] Oh, okay.

[220] Yeah, you remember we did the cryotherapy last time?

[221] Yes.

[222] Yeah, that was fantastic.

[223] Yeah, you want to do it again?

[224] Today, if you have time.

[225] Oh, fantastic.

[226] I'm in.

[227] Yeah, I was planning on doing it today.

[228] I did hot yoga earlier, so I like to do hot yoga in the morning and then cryo after podcast.

[229] That's how I like to mix it up.

[230] All right, let's do it.

[231] I don't have a cryo handy at my place, but I do the sauna and then.

[232] in the cold tub.

[233] You should get a cryout set up.

[234] They're not that expensive.

[235] You can get one.

[236] What about these infrared boxes?

[237] Are they any good?

[238] Oh, for saunas?

[239] I do not know.

[240] But some people swear by them.

[241] Laird Hamilton, who we're talking about it.

[242] By the way, how good is that coffee?

[243] It's fantastic.

[244] I might need a top up.

[245] Superfood coffee.

[246] Well, we'll get you more.

[247] Well, oh, Jeff is going off to pick up our Pablo Escobar mugshot picture.

[248] I'm obsessed with mugshots for some strange reason.

[249] Always collecting new mugs.

[250] shot pictures.

[251] We've got a giant Pablo Escobar.

[252] It's very nice.

[253] The Laird Hamilton stuff is that's got turmeric.

[254] It's got coconut milk.

[255] It's organic coffee.

[256] I'm so addicted to it.

[257] I drink that stuff like water.

[258] Yeah, I'm going to have to get myself some.

[259] Yeah, it's delicious.

[260] I mean, you can just, you don't need a machine either.

[261] You can mix it yourself.

[262] He has all the stuff.

[263] You just pour it into coffee.

[264] Yeah.

[265] I mean, he's a hero of mine for...

[266] He's a stud.

[267] What is he's 50 -something now?

[268] He's a thousand years old.

[269] The guy runs mountains.

[270] and surfs things tall as the empire state building he's a very interesting character the last i saw him uh was watching something on instagram and i saw him in a sauna with oven mitts on riding a bike like a one of those uh echo bikes like those rogue you know those aerosol bikes riding one of those fucking things in a sauna i was doing his sauna routine i did not like it i was cranking the sauna up to 220 degrees and uh i think i cooked my lungs a little bit not bad but people who listen to the podcast afterwards my apologies because i was i was coughing like that for like four or five episodes and then i had decided okay this is fucking stupid like i don't think this is good for me right well you know hormesis yes uh what doesn't kill you makes you live longer that's not exactly true you can push it a little too far sometimes yeah about booze booze doesn't kill you but it definitely doesn't make you live longer.

[271] That is true.

[272] If you drink hard every night, you look like shit.

[273] If you look at two people, one that drinks hard and their brother who just drinks water and runs all the time, boy, that water drinking guy looks fucking fantastic, doesn't he?

[274] In comparison.

[275] Well, yeah, that's probably another one of my vices.

[276] I've got to lay off the alcohol.

[277] Booze?

[278] Yeah.

[279] Well, how much do you drink?

[280] I'd probably have one or two a day.

[281] When I'm on vacation like you, I overdue it.

[282] I just got back from vacation.

[283] It's my body's way out of shape yeah i get fat on vacation man last time i was on vacation i was doing this i was grabbing my size i was in italy and i went hard i was drinking wine every now i was drinking about a half a bottle of wine every night i was eating pasta all day long but i when i'm on vacation i just go fuck it and also it kind of gives me a little project when i come back you know like all right now it's time to get serious right right well uh i was uh in africa recently and uh i got to tell you one of the When you see a wildebeest get attacked and chewed on for 45 minutes by a crocodile, nothing better than going back to the camp and having a beard or to calm down.

[284] So I did a lot of that.

[285] So when you were on safari, how did you, are you in one of those open jeep deals?

[286] Yeah, a lot of that.

[287] We did also some hiking.

[288] We had Maasai leaders that would go out with a federal officer with gun to protect us.

[289] Oh, Christ.

[290] Oh, it was fun.

[291] It's so different than being in a gym.

[292] to walk among the cats.

[293] Oh, yeah, man. For sure, you're almost dead.

[294] Yeah.

[295] It's like you're right there.

[296] You feel like you're alive.

[297] You know how you get the feeling of what it was like to be an early human.

[298] I've never encountered anything other than bears in the woods that are terrifying.

[299] I've never seen a mountain line while like hunting.

[300] I've only seen two mountain lines ever.

[301] One was from my back porch in Colorado and one was in the street in Santa Barbara.

[302] I was driving and I saw one run across the street.

[303] I didn't realize it was a mountain line.

[304] until I saw the tails like oh shit I thought it was a coyote or something then I saw that long tail um but while hunting I've the only thing I've ever seen is a grizzly bear I saw a grizzly bear once I've seen black bears black bears are unnerving grizzly bears are terrifying they look at you like this you could shoot them and they'll still come they just look right through you they look like am I eating you what's going on with you am I going to eat you like they're trying to black bears are like oh should I get out of here should I run am I the boss or you the boss I'm Like, they're not sure.

[305] Grizzly bears are fucking sure they're the boss.

[306] He's trying to figure out whether or not they should eat you.

[307] Right.

[308] And actually, one of the things you realize when you're amongst these animals, it's a huge privilege for us to go for a walk without getting eaten.

[309] Yes.

[310] Yeah.

[311] We don't think about it that way because we're so used to being in parks and, oh, I'm out in nature.

[312] The fuck you are.

[313] You're not really in nature.

[314] You're some weird sort of nature preserve that we've sort of set up inside cities.

[315] Right.

[316] And people ask me about my work.

[317] Oh, isn't what you're doing unnatural?

[318] No, fuck natural.

[319] What about our weld is natural anyway?

[320] Brushing your teeth isn't naturally, they're stupid.

[321] Right.

[322] Yeah, you're born with a toothbrush in your hand?

[323] Shut up.

[324] Right, right.

[325] So dumb.

[326] I flew over here, what?

[327] I had 30 ,000 feet drinking a cocktail, surfing the internet.

[328] Not so natural.

[329] That's natural.

[330] You're getting bombarded by solar radiation.

[331] You're boozing it up.

[332] You're also somehow or another online.

[333] No way that anybody's ever going to be able to explain to me that my puny brain's can understand.

[334] Right.

[335] Yeah, exactly.

[336] Well, yeah, don't give me the argument that aging is natural, therefore it's acceptable.

[337] I don't buy any of those natural things, because everything on Earth is natural, even chemicals.

[338] We're not getting them from the stars.

[339] We're not pulling them out of other dimensions.

[340] Like, what are you talking about?

[341] It's all from Earth.

[342] Everything.

[343] Right.

[344] Even pharmaceuticals.

[345] Most of them are derived from plants.

[346] Sure.

[347] In Africa, I was hanging out with the Butwa tribe.

[348] These are the pygmies.

[349] They used to be in the forest, and I had the chief take me through the forest, and he was showing me all the drugs they used to take.

[350] there's this clostidinium i think i'm saying it right it was a leaf they used to chew on they'd smoke a bit of weed they'd go a little dizzy they'd crouch down after about 15 minutes they'd stand up and they felt invincible they'd go kill one of those uh elephants in the jungle jesus pygmy's killed elephants yeah mini elephants oh the smaller elephants yeah but now they can't they're smaller people right it's all mini out there they can't except the worms the worms were about this long my buddy justin wren we're a big supporter of a fight for the forgotten charity it's charity that my friend Justin Wren set up and they build wells for the pygmies in Congo and through this application called the Cash App and I personally donated to and we also were doing benefits for them.

[351] We're doing a big benefit in L .A. coming up soon that'll be announcing soon.

[352] But he goes over there all the time and he's had malaria three times and just recently has acquired some unknown parasite that is just devastating his health.

[353] He's trying to figure out what it is, so he's got to go through a battery of tests, and they've got to, you know, examine him.

[354] But next time he goes over there, apparently, he's going to bring his own food.

[355] But, I mean, the fucking poor guy's got malaria three times.

[356] Yeah.

[357] Well, he should be taking his medicine more often, I think.

[358] Well, no, it recurs.

[359] Does it really?

[360] Yeah.

[361] Because you can't get rid of it.

[362] Well, it becomes systemic.

[363] Right.

[364] It's horrific, man. I mean, the way he describes it.

[365] And he's a gorilla.

[366] I mean, a fucking gorilla.

[367] He's a huge man. He fights for bellatory.

[368] He's one of their heavyweight contenders.

[369] So he's this, you know, 250 pounds stud of a guy who goes over there and catches these horrific diseases and just like barely survives.

[370] Right.

[371] He gets the medication and comes back.

[372] But then when he gets sick, sometimes it'll kick back in again.

[373] It's kicked back in twice.

[374] Another reason you don't want to go back to natural way of life.

[375] But you're a good man, Joe, for supporting the pygmies.

[376] I was Justin as such a fucking angel.

[377] When you talk to him and you see his documentaries that he's put out and his films that they've done with water for and now just with his organization, fight for The Forgotten.

[378] Like, you can't help, but help.

[379] Oh, gosh.

[380] I was on the Ugandan side of the volcano rift, and the way they live was just, it was shocking.

[381] And we're going to help rebuild a school for them, but they need help.

[382] And they're right on the edge of civilization.

[383] The Batwar tribe, the pygmies are in the worst situation than anybody.

[384] And they're the lowest of the low.

[385] They're picked on racially.

[386] They were kicked off their land to save the gorillas and these elephants.

[387] And they don't know what to do.

[388] They've got everything they knew how to live is gone.

[389] Isn't that crazy?

[390] They're kicked off their land to save animals.

[391] Right.

[392] Yeah.

[393] Well, yeah, but there's no way out.

[394] You've got to do that.

[395] Well, isn't there a way to not kill the animals and have them all coexist?

[396] I guess you could have kept them in.

[397] It's a national park, so you can't.

[398] easily have humans living in the National Park.

[399] I suppose you could, but they are trying to modernize them.

[400] So they put them on this small few acres of land, which they're trying to learn how to farm.

[401] And the way they subsist is through tourism.

[402] So I would recommend anyone who's interested, go see them, support them, buy a lot of stuff.

[403] I think we bought up quarter of the village.

[404] They love that.

[405] But we're going to go back and do something meaningful.

[406] That's awesome.

[407] That's awesome.

[408] Natural.

[409] So we were taught, we got rid off the sidetrack.

[410] So you You were in Africa, which is the most realistic environment.

[411] I mean, if you want to really know what nature is all about, you were in the most realistic environment.

[412] It's all tooth, fang, and claw.

[413] It's like whatever survives survives and whatever doesn't becomes food, and there's just this constant cycle going on.

[414] And you're walking around.

[415] Yeah.

[416] Now, when you walking, were you walking when you saw the crocodile eat the wildebeest?

[417] No. You're in the Jeep.

[418] I was in the Jeep for that.

[419] How does a Jeep thing work?

[420] Why don't they just jump in the Jeep?

[421] I don't understand that.

[422] Good question, and I ask myself that as they were walking by.

[423] Same with the guerrillas.

[424] They've been habituated to humans.

[425] They literally don't even see the Jeep.

[426] Well, the guerrillas don't, you know, they're not aggressive unless they think you're a threat.

[427] They don't eat meat.

[428] They're just eating plants all day.

[429] Yeah, they're still pretty dangerous.

[430] One swipe from a gorilla.

[431] Oh, my God.

[432] Grayback, silverback.

[433] Yeah, it's interesting that the jeeps have been around for so long.

[434] they just go under the Jeep They're going to see Yeah, yeah It's as though the jeeps aren't there You might have six jeeps looking We saw some lions rip apart a Impala Right in front of us And they're just going about their daily lives Did you see it catch it?

[435] Just missed that We saw them running away Oh god If I saw them running in real life I'd shit my pants Well they were running towards our camp So we were running the other way Oh dude I heard a horrible story about these people They were on safari camp this person went to use the bathroom in the middle of the night.

[436] Apparently, you know, there's cabins and you have to leave the cabin to go to the bathroom.

[437] And the cats went in the bathroom and got them and dragged them out.

[438] You're kidding?

[439] No. That's the worst way to go.

[440] Yeah.

[441] It's the hyenas you got to watch out for because they'll actually eat you alive.

[442] Oh, fuck.

[443] Yeah.

[444] The locals don't like the hyenas.

[445] They don't have respect.

[446] Any animal that eats another animal while it's still screaming.

[447] Oh, yeah.

[448] They don't give a fuck.

[449] They don't try to kill you.

[450] They just eat.

[451] Yeah, that wildebeest had a broken leg It got away from the crock But it was It's bush meat at that point Yeah But there were people in the Jeep Some other Americans Chearing It was like a sport for them Oh no I didn't appreciate that Fucking American It was a solemn moment This animal's gonna die And they're like woohoo Ew And they were chasing it Must be men right It was mixed It was girls I'd be super concerned I think it was a few But If girls were cheering Yeah, fuck him Might have been I think it was the guy's cheering But they were chasing this poor animal It's hoof had been broken off And it was running on a broken leg And they were chasing it The people were?

[452] The Jeep And the people in the back of the Jeep Yeah my kids were with me They were screaming and crying It was emotional I don't want to see that Yeah Yeah I've never seen anything Take anything out in the real world It's shocking You know you can see it on BBC or whatever As much as you want But when you see it live My friend Johnny Hamilton, he works at a ranch in Colorado, shot out to Johnny.

[453] He was following the trail of this gigantic elk.

[454] They'd seen all these footsteps, and then they'd seen mountain line footsteps.

[455] And then there was no more mountain line footsteps.

[456] And then they followed it about 100 yards or so, and they found the cat on top of the elk.

[457] It had jumped on the elk's back and killed the elk.

[458] It's a 150 -pound cat, a 900 -pound elk, a big bull, and it just leaped up on its back and just got a hold of its neck and dragged it to the ground, but it rode it for like 100 yards.

[459] Yeah, the crock did this too, to the Wildebeest.

[460] So elephants are interesting.

[461] We saw a lot of those, and what we learned was that the old elephants, because they've run out of their teeth, their teeth wear down, and at some point they just can't chew anymore, so they have to find really soft stuff.

[462] Eventually they die.

[463] And that gives rise to this legend That there's this graveyard for elephants Not a graveyard, it's just where the soft food is But I was thinking if elephants had technology They could easily solve aging They just get dentures and leave them along Yeah, why can't we just trank them And give them some implants Yeah, well They do it with people, right?

[464] I think in the zoo they might do something like that Do they?

[465] They do with dogs My teeth rebuilt, they were wearing out Yeah, I've seen that before with people It's cool It made sense They fix my daughter's teeth But I said to the dentist I know we're changing topic here, but it's funny.

[466] I said to the dentist, can you fix my teeth?

[467] You just did my daughter.

[468] They went, oh, no, you're almost 50.

[469] We don't fix teeth at 50.

[470] Excuse me?

[471] Because they feel like you're on your way out.

[472] Exactly.

[473] Yeah, someone said that to me in terms of meniscus.

[474] I had a meniscus tear.

[475] And they said, well, when you're younger, you have more blood flow to your meniscus, and we would just surgically repair it and hope it would fix.

[476] Or perhaps today use stem cells.

[477] but most likely because of your age, it's not going to heal correctly.

[478] And I'm like, okay, I'm confused because you're talking about blood flow, like blood flow.

[479] Like, what is happening that's different?

[480] I don't, I think this is like some old medicine nonsense.

[481] Like, is blood not flowing?

[482] I mean, I, well, it's flowing.

[483] And someone with your fitness is flowing probably as much as a 30 -year -old anyway.

[484] I'm in better shape than I was when I was 30.

[485] I do more shit.

[486] I do more running.

[487] You know, I'm like, I'm got a lot of blood flowing around, man. I think they compare you to sedentary people.

[488] For sure they do.

[489] That's the problem with most medicine is that it's tailored to the average person.

[490] Yeah.

[491] We got to fix that.

[492] It's got to be personalized, tailored, measured.

[493] I think if I wanted to go on safari like that, like you did, I would have to make sure that I wasn't around any cheering assholes like that.

[494] I would have to take some sort of a solo trip and I'd have to be heavily armed and then wearing armor, some sort of armor.

[495] Well, so that was in Tanzania.

[496] And a flamethrower.

[497] Yeah.

[498] I bring the Elon Musk flame throw with me. Right, right.

[499] Fuck those things, man. Did you ever see Survivor Man?

[500] Do you know Survivor Man?

[501] Yeah, sure.

[502] Les is a great guy.

[503] But he's committed to finding Bigfoot now.

[504] It's all he's doing these days.

[505] All right.

[506] Yeah.

[507] But anyway, Les did an episode where he did Survivor Man in Africa.

[508] And the scenario, he would create these fake scenarios.

[509] You know, just man -made scenarios.

[510] Like, what is?

[511] if you were in a hot air balloon and the hot air balloon got a hole in it and crash landed in these lion infested territories.

[512] So he literally did that.

[513] That's insane.

[514] In the basket.

[515] So he had a few items in the basket and the flame thrower for the hot air balloon with him to ward off the fucking lions.

[516] So here he is, it's nighttime in Africa.

[517] And by the way, he self -films everything.

[518] you know the reason why they came out with that other show with that who's that other dude the other dude that that got busted like sleeping in the holiday in he got he's going to the yeah bare grills he was going to the four seasons at night he's like this is how you could do it but i'm not going to do it he would he would show you how to do it you could sleep in an igloop but meanwhile he would fucking he was getting room service and eating steaks and shit yeah that's what i do but less shroud really does it i mean he brings a series of cameras so this is him and Les went and he so he pretends the thing crash landed so this is his scenario that he's created for himself but the reality is he really is surrounded by lions and so he has a limited amount of propane and he would fire up look at look look he would fire up that thing which is what you use to get in the hot air balloon and scare the shit out of the lions so through the night he would hear he would hear that look at the fucking zebras and shit so he'd hear it in the middle of the night and you'd have to fire that thing up to scare everybody the fuck away and then after an hour or so they'd be like oh fuck time to fire it up again and so he was out there sleeping in this basket trying yeah so crazy he's so crazy and he would also do these things where he would have virtually no food for seven eight days you know and just really just get super super skinny and almost starve to death that's the opposite of being in a jeep he's got like a bottle water i got a pocket knife i got some rope like this is how you do it i got a stick what is that oh some sort of a machete type thing fucking crazy yeah we went up in a balloon uh which was beautiful by the way it's fun isn't it i did that in italy recently yeah really wild yeah it's uh anyone who's afraid of heights don't worry it's beautiful but we had a truck underneath us with people with guns just in case that happened oh that's good yeah so they're following you yeah there's a whole industry and keeping people alive that want to stupid shit.

[519] Yeah, right.

[520] You can imagine, oh, sorry, the Serengeti burnt down, yet with some guy in a balloon.

[521] How many days, right?

[522] How many days did you go there for?

[523] We traveled for 16 days.

[524] I took my whole family, brother, his kids.

[525] How old are the kids?

[526] Two nephews, and my kids are 16, 14, 12.

[527] Perfect age for this.

[528] And they don't recommend you being under a certain age if you're going to take malaria medication, right?

[529] They all did.

[530] Whoops.

[531] Really?

[532] I don't, I think 12 might be okay But I think it's like under 10 or something like that Where they's, you know The stuff is heavy duty Like did it fuck with you?

[533] Did you have crazy nightmares?

[534] I took the one that doesn't give you nightmares But my other siblings had that My father came, so he's 80 And that was actually the reason we went To his 80th birthday present Oh wow, that's cool What a cool present 16 days It was awesome We went Kenya, Tanzania, Uganda What did you like best?

[535] Tanzania is supposed to be gorgeous.

[536] Yeah, Serengeti was incredible.

[537] It was all good.

[538] I really liked hanging out with human beings, too.

[539] They're interesting species.

[540] Oh, for sure.

[541] Yeah, I enjoy humans.

[542] Yeah.

[543] So it was the origins journey, I called it.

[544] And so we went to, we started in Oldavide Gorge, which is where humans, the original fossils were found, going back a few million years.

[545] Wow.

[546] And started there and then just went through looking at the various animals.

[547] So we saw the guerrillas.

[548] And we ended up a few days ago I was in Jerusalem looking at where we come.

[549] Oh, wow.

[550] A real origins tour.

[551] Yeah.

[552] Up the crack.

[553] That's exciting, man. That's exciting.

[554] Wow, that is so cool.

[555] So what was the most unusual thing?

[556] Besides Jerusalem.

[557] Was that the most unusual thing?

[558] That's the most insane thing where all the religions are on top of each other, touching rocks and blessing the spring.

[559] And humans are crazy.

[560] They'll worship anything.

[561] Well, I'm sure.

[562] sure you've seen i was in germany once and uh was there for ufc and i was flipping through the channels of the television and there was uh this live feed from mecca and uh this was pre instagram i was not on instagram i definitely would have because i watched it for hours i just sat there in my room drinking a cocktail with my feet up watching this these people circle around this what is that square shaped thing in the center of mecca yeah i forget what's the religious object that i believe i think says something to do with an asteroid like there's a piece of some find out that makes sense this is important to people but the uh the the watching people circle they're all wearing the religious garb this islamic garb that they have to wear and they're all circling around this thing like for hours and hours and hours and it's oddly appealing Like part of you once ago, I recognize that there's got to be a very strong sense of unity and community in everybody agreeing that we are all going to treat this.

[563] This is a sacred object.

[564] This is a sacred place.

[565] We're going to wear sacred clothes.

[566] We're all going to follow this path.

[567] And we're all going to be together in this.

[568] Like this super reinforced sense of community that's actually ordained by.

[569] God himself.

[570] Well, we all need that feeling.

[571] For me, it's science and the fossils that I and my colleagues believe were the origins.

[572] Everyone needs an origin story.

[573] Here it is.

[574] How would you say that?

[575] Kabah?

[576] Kabah.

[577] It's built around a sacred black stone, a meteorite that the Muslims believe was placed by Abraham and Ishmael in the corner of the Kabah, a symbol of God's covenant with Abraham and Ishmael, and by extension with the Muslim community itself.

[578] Hmm.

[579] Okay.

[580] Yeah.

[581] So it is actually a meteorite, which how incredible, right?

[582] Like a little bit of science and a little bit of religion all wrapped up together.

[583] There's a discovery.

[584] So this is what it looks like.

[585] So you're watching this.

[586] The channel that I was watching in Germany, again, this is probably like more than 10 years ago, 12 years ago perhaps, and watching this circle around this like religious spot.

[587] It was very, very careful.

[588] captivating.

[589] Yeah, the one that I remember most from, I think was Jerusalem, yeah, was people touching the stone where the crucifix was thought to be, and they were lined up for hours to just touch it for a few seconds.

[590] Meanwhile, the origin of humans, the fossils, there's maybe two or three people hanging out.

[591] No one really cares.

[592] Admittedly, it is out of the way.

[593] It's not in the middle of Middle East.

[594] But still, it struck me that humans are more focused on these icons of religion rather than where I believe we really came from.

[595] Africa, yeah.

[596] Oh, I mean, if you look at it and you see it, you touch it, you feel it.

[597] It's the only sensible explanation.

[598] I mean, you can still have religion, that's fine.

[599] But, you know, don't tell me those fossils were put there by somebody.

[600] No, I mean, obviously not.

[601] But it is that the idea that a human being came from some lower hominid, which came originally from a shrew is so, so hard to follow.

[602] Like, if you go all the way back to 65 million years ago to the asteroid hidden in the Yucatan, and you're like, wait, what happened?

[603] Like, yeah, yeah, yeah, big rock, smashed, killed everything, except like these little rodent things, and they just eventually evolved.

[604] Yeah, but that's what I love about science.

[605] It's amazing.

[606] It's amazing.

[607] It's actually true.

[608] Yes.

[609] We can prove it.

[610] Yeah, I mean, you can really follow the fossil record.

[611] That's one of the funny things when people go, oh, what about the missing link?

[612] There's holes in the fossil record.

[613] Well, it's holes in your education.

[614] But it's not holes.

[615] I mean, they go out to Australia Epithicus.

[616] Explain Australia Epithicus.

[617] Explain the various other human beings.

[618] You know, explain homo Floriansis.

[619] Explain the Neanderthal.

[620] Explain all these different.

[621] There's a whole slew of different fucking things that were human.

[622] Like, what was that?

[623] God's experiments?

[624] Was God fucking around?

[625] Yeah.

[626] I was like, let's try to make them super.

[627] short and wide and thick and heavy like a five foot seven 200 pound person that's way stronger than a person to add those are no good listen let's get a taller skinnier one but with bigger brains aha right and let's have them breathe that's what we did let's bang them yeah everybody bang I don't know if it was marriage or rape but something happened I think most rape mostly most breeding was rape until about like 500 years ago I agree with you do you know that to this day there's a country is it Kurdistan?

[628] What is the there's a country that 20 % of all marriages begin in kidnapping no way so there's a shame to the female being kidnapped and she ultimately has to marry her captor find out that's, is it Kurdistan?

[629] Kyrgyzstan?

[630] I'm not saying that.

[631] Yeah, how do you say that?

[632] Kyrgyzstan.

[633] I think it's Kyrgyzstan.

[634] Okay.

[635] Silenzy.

[636] Yeah.

[637] One in five girls and women for marriage in Kyrgyzstan.

[638] How fucking crazy.

[639] This is 2019.

[640] But the fact that you could kidnap someone, rape them, and then they get shamed into marrying you.

[641] Well, I was shocked in Jerusalem.

[642] I'm going to probably have a lot of hate mail for saying this.

[643] But it's a fact that when you go to the wailing wall, as I did, and put a little note in the wall, which was great experience, by the way, there is a space for men and women.

[644] They're separated.

[645] But the space for men is for, or five times bigger than the one for women.

[646] Good.

[647] No, sorry.

[648] I couldn't help myself.

[649] Yeah, it's all this disparity.

[650] Anyway, so...

[651] So are there a similar amount of women that are going to this wall and they're just jammed into a smaller area?

[652] Yeah.

[653] Still, 2019.

[654] Is this ordained?

[655] Is there some sort of a religious...

[656] Yeah, the Orthodox.

[657] Apparently behind that, I checked it out.

[658] So there's an actual scripture that says men are supposed to have this area.

[659] Oh, gosh, I doubt that.

[660] So it's just...

[661] ancient sexism.

[662] Well, yeah, and even the wall is just tradition.

[663] Yeah, right.

[664] But anyway, the history of humankind is interesting, and I did that because...

[665] Oh, that's the wall right there.

[666] What's all the black spots?

[667] That's like...

[668] Holes.

[669] Grass.

[670] That's like plant material, I think.

[671] Is it?

[672] Yeah.

[673] Yeah, yeah.

[674] The plants growing out of the wall.

[675] Well, oh, it is.

[676] Okay, they're not black.

[677] We're just looking at low resolution.

[678] That's the women's side.

[679] That's the men's side.

[680] Do you remember the scene in...

[681] What is the World War Z?

[682] when all the zombies climb up the wall they pile on top of each other like uh did you see world war z no fucking great movie i gotta say it there's a there's a crazy scene it's a brad pitt zombie movie or all the all the zombies pile up on top of each other and make it to the top of the wall you got it yeah james's gonna pull it up so they get to the wall and look at these fucking zombie people are climbing up yeah oh it's it's pretty gnarly man you've never seen this movie i've wanted to The novels are supposed to be excellent.

[683] Weren't the novels written by some famous guy's son?

[684] Who wrote the novel?

[685] But this is a great scene.

[686] See, they're all piling on top of each other, and they're just reckless.

[687] They have no concern for their health or well -being, because they're, you know, look, they're dead.

[688] So they're just making this human thing, and then the soldiers are shooting into the pile, trying to knock them down, but they get over the top of the wall, and they start infecting.

[689] people it's a pretty wild ass movie yeah who wrote that movie it's a wild movie man this is it's one of those um zombie movies where the zombies move fast that the slow zombie movies which come on man like that's why walking dead like I feel like you could fuck those things up I mean they can only last so long they don't move fast like how are they surviving they're just kind of like shuffling towards you I feel like if you just have a big sword you can just start hacking away yeah so there are there are zombie cells in the body and i i make that segue because people are going to say why the hell aren't we talking about aging oh we will okay we're here forever max brooks the son of melbrook ah ha there you go shout out to max brooks and melbrooks sorry aging well we don't have to zombie cells yeah so what are they are we done talking about africa and your trip it's your show because it's pretty exciting uh it was your show too thank you when you're on it your episode uh well so else?

[690] I recommend everybody go to Africa, not just to come back a different person, a better human being, but also to support them.

[691] They really need a help over there.

[692] When you were in the area where the oldest human -like fossils were found, what's the feeling like when you're in this area?

[693] You really are where the origins of humankind are from.

[694] I mean, that has got to be a pretty profound feeling.

[695] Yeah, it was spiritual.

[696] Unfortunately, the people who drove us there were saying, hurry, hurry, we have to go see some zebras.

[697] This is more important than the zebras.

[698] These are the people that are the guides?

[699] Yeah, they don't know what was important to us.

[700] Fair enough.

[701] But I would have loved to have spent a whole day there.

[702] Apparently, there are still fossils sticking out of the walls of the...

[703] Really?

[704] Yeah, so the reason that it's...

[705] Are you allowed to do anything with them?

[706] I don't know.

[707] What happens if you find a fossil?

[708] Do you have to contact the university or do you just like, shut the fuck up?

[709] Well, actually, I probably shouldn't confess this on live media.

[710] Don't do it, bro.

[711] Tell me later.

[712] It's not so bad.

[713] Okay.

[714] You can actually find a whole bunch of stuff in Africa that's interesting if you look down rather than out.

[715] And my oldest daughter, our oldest daughter, Alex, she looked down.

[716] She's a scientist.

[717] And so she, 16 -year -old scientist, she found a whole bunch of stone tools.

[718] Whoa.

[719] Not there.

[720] Not in old of iGorge, that's sacred.

[721] But, you know, just out on the Serengeti or wherever.

[722] Did you get them analyzed?

[723] Not yet.

[724] They recently found stone tools in the United States that they've brought back to 16 ,000 years ago.

[725] The oldest known stone tools of any human being.

[726] And it's sort of they're slowly but surely pushing back the dates of human civilization in America.

[727] And one of the more recent discoveries was stone tools.

[728] that are from 16 ,000 years ago.

[729] So people had made their way over here, or here it is.

[730] Oh, I remember I asked you about this.

[731] You said you never saw it.

[732] I don't know if you saw it yet.

[733] They said it, I don't know if they have a video of it, but they said they saw this monkey sharpening that stone before it was actually breaking the glass with it.

[734] Monkey shatter's zoo glass with sharpened stone, an impressive prison break attempt.

[735] Man, fuck keeping monkeys in a cage.

[736] That drives me so crazy.

[737] I hate it.

[738] I went, I took a pot edible once, like a real strong one, and I went to the zoo, and it was so depressing, staring at the chimps.

[739] I just sat across and watched the chimp cage.

[740] I'm like, oh, my God, these things are in hell.

[741] Yeah.

[742] They're just in prison.

[743] Even keeping little birds in cage, little cages like this.

[744] Yeah.

[745] But the monkeys are wailing.

[746] That's worse.

[747] Right.

[748] They're wailing.

[749] They had some type of monkey that was in a smaller cage than the champs.

[750] It was just wailing.

[751] Wah!

[752] It was just in hell.

[753] Yeah.

[754] It is.

[755] It's brutal.

[756] Well, actually, the stone tools are interesting because, again, getting to what's natural.

[757] What's natural for primates is to change their environment, to take tools to, you know.

[758] So what we're doing, genetic engineering.

[759] Well, I don't want to say engineering, but we're using genetics to understand why we age and why we don't have to.

[760] It is natural.

[761] Of course.

[762] That's what we do.

[763] All of science is natural.

[764] You could even argue that an iPhone in your pocket is natural.

[765] Sure.

[766] Humans have created it.

[767] They exist all over the world.

[768] I've argued that cities are natural It's a completely Normal thing for humans to do to create cities To say that cities are unnatural Well, why are they everywhere And why are human beings making Are you saying beehives are unnatural too?

[769] Right.

[770] A clothes are unnatural?

[771] Well, animal habitat I mean animals like beavers create beaver dens And they're very uniform They're real similar everywhere they go Exactly.

[772] Yeah, the other day Someone said humans tamed fire 500 ,000 years ago And I said that can't be true 500 ,000 years ago, that's, you know, too long ago.

[773] I checked it out.

[774] It's true.

[775] And these weren't even humans.

[776] These were pre -human, I think it was probably one of the two species back.

[777] We've been doing this.

[778] We've been changing the environment using tools, using fire for that long.

[779] The fire one is crazy, right?

[780] Because it's not just manipulating a physical thing.

[781] It's changing the state, right?

[782] You're doing something, whether it's with Flint and, you know, something to spark and some tender.

[783] You're really creating, changing the state.

[784] of matter.

[785] Well, we are.

[786] And we'll continue to do that.

[787] We'll continue to evolve.

[788] And one of the reasons that I wanted to see human origins is, in my book, I talk about we've evolved to our natural lifespan.

[789] We're now at a maximum.

[790] 122 is the longest -lived human that ostensibly is on record.

[791] So without intervention, we've reached our maximum.

[792] But why not now give us what evolution failed to give us?

[793] Why can't we be like other species that are at the top of their game?

[794] Are there any factors when you look at the oldest people that are alive?

[795] Are there any common factors?

[796] Actually, not really.

[797] They do seem to have a collection of gene variants that predispose them to get to that long.

[798] There's one called Fox O3, that if you've done your genome, we can have a look.

[799] 23 and me. Have you done it?

[800] I have.

[801] We should look at it.

[802] I can tell.

[803] You need an A or a T at a certain position.

[804] I've got one of them out of two.

[805] my kids got two of my kids out of three have both so they if they look after themselves might have a better chance of living longer but anyway these long live people they tend to live a long time no matter what they do often they smoke till 90 years old really yeah they quit at 90 there's a few cases of that and they live another 12 years right right more 22 years right you said 122 years old that lady that's one one lady in France But one of my friends, his name is Nira Barzlai, he was with me in Israel.

[806] He's got a story of when he asked the centenarian lady, the lady that lived over 100, that he knew, why didn't you quit smoking?

[807] And she said, all four doctors I went to told me to quit smoking, and they've all died.

[808] So I keep going.

[809] That's hilarious.

[810] What did she do for a living?

[811] John Calman.

[812] I forget.

[813] The French lady, I don't remember what she did.

[814] I would imagine that would play a part, like, how stressful your occupation is.

[815] Yeah, she had a great sense of humor.

[816] That was probably part of it.

[817] She used to make jokes with her reporters all the time.

[818] One was, how many wrinkles do you have?

[819] She says, I've only got one, and I'm sitting on it.

[820] The other one, I think, is even better, is a reporter who was young said, you know, you're 116.

[821] I hope I see you next year for your birthday.

[822] She says, I don't see, why not?

[823] You seem pretty healthy to me. Wow, and she made it to 122.

[824] Now, have there been any anecdotal reports of people that lived longer?

[825] Well, Methusel are in biblical figures.

[826] No, yeah, but not biblical, like, not unsubstantiated reports.

[827] Because I had heard of, you know, there's some people that claim to have lived, like, ridiculously long, but they've never really figured out whether or not it's accurate.

[828] Sure, there's a few of those.

[829] But even John Coleman at 22, there's a big argument now between us.

[830] researchers, whether that's even true.

[831] Oh, really?

[832] Yeah, it's a massive debate.

[833] I've got an inbox full of long, angry emails from scientists.

[834] What's the evidence point to the contrary?

[835] That to, so the hypothesis is that she, her identity was subsumed by her daughter to avoid paying taxes.

[836] Oh.

[837] And there's photos of them, and there's a blotch on one photo that matches the daughter.

[838] So there's a lot of forensics going on, and people want to subsume the grave.

[839] And the French government's not, or French researchers aren't giving up the blood samples.

[840] They don't want to know.

[841] Oh, they don't want to know.

[842] So it's probably horseshit.

[843] Well, it's probably like 100 years old.

[844] It could be horseshit.

[845] I would say it doesn't actually matter.

[846] God damn French.

[847] It doesn't matter.

[848] People have lived 117.

[849] And that's still pretty good.

[850] That's what we know.

[851] You know, if we can all live that long, who's going to complain?

[852] Wouldn't you like to get one of them old, old, old, old people and start doing work on them?

[853] Yeah.

[854] Just pump them up with N. D, get him on a drip.

[855] Well, my dad's experimenting on himself.

[856] So he's not 100 yet, but he's 80.

[857] How's he look?

[858] Well, I wouldn't say he looks young, but his fitness is like a 30 -year -old.

[859] Really?

[860] He's stronger than me. We tested it out in the gym the other day.

[861] No way.

[862] That's embarrassing.

[863] He can lift more.

[864] He's fitter.

[865] We were going across the Serengetti, and he was leading the charge.

[866] If you saw him, if you didn't see his face because he's got gray hair and whatever, physically put a bag on his head, you'd say he's 30 the way he moves.

[867] People were very weird to put a bag on your dad's head.

[868] Yeah, I shouldn't do that.

[869] Sorry, Dad.

[870] You would think he's 30, really?

[871] Well, he's reinvigorated in life.

[872] So, in my family, we've got some Ashkenazi bad genes.

[873] We tend to die young.

[874] And my grandmother died.

[875] My grandmother's actually only 15 years older than my dad, and she died a few years ago.

[876] The last 10 years of her life, horrible.

[877] So we know what's going to happen in my family, probably, to all of us.

[878] So your grandmother had your father when she was 15 years old?

[879] Right.

[880] whoa yeah back in the early days of World War II she apparently was playing around with her boyfriend she claims to be a virgin but at that point but something got somewhere that shouldn't have and during high school right so I was raised by my grandmother she was in her 40s when I was a kid and she was the one that taught me to always stay young keep your you know adults ruin everything that's probably why I work on aging that's it's adults ruin everything that's adults ruin everything thing?

[881] What was her advice, like, in terms of, like, why, how do you avoid what adults are doing wrong?

[882] Well, you know, she'd grown up during the Depression and then World War II, and then the communists came into Hungary and raped a lot of people.

[883] She had no, she had no respect for humanity.

[884] So by the time I came along, first of all, she put all of her energy into, to me, and I was a spot bright as a kid.

[885] So that was, it wasn't.

[886] helpful to me, I think now as an adult.

[887] But more importantly, she wanted me to do the best I could with my life.

[888] She said, David, do what you can to make this world a better place.

[889] Make sure that you leave this place better than you found it.

[890] And that's what I'm trying to do.

[891] Wow, what a profound piece of advice for a grandchild.

[892] She was a rebel.

[893] She taught me, forget the rules, right?

[894] Kind of like you do.

[895] I'm going my own way and we'll see how this goes.

[896] She, so she went to Australia.

[897] She said, fuck Europe, I'm out of here.

[898] She went to Australia, the furthest place she could find from Europe, never went back.

[899] She went on Bondi Beach in Sydney, in a bikini, which was rebellious.

[900] And she got taken off the beach by the police.

[901] What'd you have to wear back then?

[902] Oh, the full little British thing.

[903] Down to your knees?

[904] Oh, down to your knees?

[905] I think so.

[906] What did they look like?

[907] Maybe it was a one piece, but certainly not to show your belly.

[908] That's what I think.

[909] But she was a rebel.

[910] She went to New Guinea by herself in the 60s.

[911] What year was this where she was wearing a bikini?

[912] Oh, that would be 56.

[913] You couldn't wear a bikini in the 50s?

[914] Wow.

[915] Okay, like those pin -up girls, right?

[916] When you see them, they always had one -piece suits on.

[917] Like, yeah.

[918] So imagine New Guinea in the 60s as a woman on her own up in the highlands.

[919] She claims to have eaten human flesh.

[920] I'm sure she spent most of the time drunk as well.

[921] Did you see that article that was yesterday where they were interviewing an Australian a guy who's a doctor or a scientist who was talking about climate change and he was saying that we have to start eating human bodies and that human bodies are very nutritious and that we just put them in the ground and like I was reading it and I was like okay is this guy trolling like what is he doing here?

[922] Is he a completely insane person but his advice was our dependence on meat is ruining, like in some places where they're, you know, they're stripping the rainforest to make room for cattle grazing.

[923] He was saying that we're getting rid of perfectly good meat every time we put someone in the ground.

[924] Well, we are, but to suggest that, it sounds insane to me. Yeah.

[925] Because we throw away half our food anyway, at least in this country.

[926] It was a mainstream publication that this guy was talking about.

[927] It's like, the last thing you want to encourage is people getting used to eating people.

[928] been watching world war z maybe yeah i mean it's just one of those things it is me but come on i was i was going is this guy just trying to get attention like this seems like such a or is it did he was he joking and it's hard to tell in text you know yeah well yeah did you say that not every australian is sensible i found the article but i don't see anything about him saying wasting human bodies or meat it's been a more than several articles written on it maybe somebody extrapolated.

[929] But the idea was he was saying that people should eat meat.

[930] And if they want to eat meat, they should eat human meat because it's going to waste.

[931] Maybe he's an animal rights activist.

[932] Might be just an idiot.

[933] Eat your relatives, yeah.

[934] Yeah, but just the last thing you want is people getting the taste of people, you know?

[935] Right.

[936] No, I do not need to go that far.

[937] Not yet.

[938] Speaking of the food supply, one of the things people worry about if we all live longer is we're going to out of food and run out of space.

[939] And one of the things I address in the book is what really will happen if you do the calculations.

[940] If you look at human history, that is not going to happen.

[941] I'm of the strong belief that we can engineer our way out of just about any problem.

[942] Probably the only thing we can't engineer our way out of is if we get hit by a five -mile -wide meteorite.

[943] But everything else, I think we're going to be...

[944] You think climate change?

[945] We're going to be able to engineer our way out of that?

[946] Well, I don't think we can stop climate change at this point.

[947] It's definitely happening.

[948] you can see it all around, but will it wipe us out?

[949] No. Will it cost us trillions of dollars?

[950] Yeah.

[951] And so I don't think it's going to be the end of us, but it's going to be a challenge to continue to survive and proliferate as a species in the face of all of those costly things.

[952] And that's the biggest problem of climate change besides species loss is the expense.

[953] And, you know, there's only a certain amount of human capital that we have to spend, and we call that money.

[954] And that's one of the reasons that I'm excited about extending people's health and lifespan, is that that'll save tens of trillions in the globe each year.

[955] And that's money that can be put to combating global warming, saving species, besides, you know, wonderful people who donate their earnings as well.

[956] But really, to solve the big problems on the planet, one of them is to solve what are we going to do with all the frail, elderly people?

[957] people that are coming right every year more and more make him productive like my father he could be in a nursing home like his mother was whereas now he's hiking in the jungles looking at watching gorillas with his five grandkids how cool is that that's pretty cool now what kind of protocol is he on uh pretty much the same as me although he does more exercise uh so it's a combination of enumann um metformin and resveratrol and what kind of exercise um um I'm not sure of his protocol.

[958] We're going to post that on social media once we get that written.

[959] But I know it involves a fair amount of aerobic exercise.

[960] He does rowing and walking upstairs.

[961] So he managed to climb, I think it was 40 flights of stairs in 15 minutes, which for an 80 -year -old was quite a record.

[962] 40 flights of stairs in 15 minutes.

[963] Holy shit.

[964] Yeah, the guy's a phenomenon.

[965] What has happened, though, is that his outlook on life has changed.

[966] He was depressed, not just because he was fearful of getting old, and my mother was sick at the time.

[967] But now he's looking forward to another 10 years of vigorous life, traveling.

[968] And, you know, when you're healthy, you're happy.

[969] So when he was depressed, was he sedentary?

[970] No. No, he was depressed because he was worried about his health.

[971] He figured he's going to be like all his other friends, getting frail, can't walk, losing your mind.

[972] And it hasn't happened to him.

[973] So just a few years ago, he went back and started a new career.

[974] Whoa.

[975] Oh, we talked about this last time, I believe.

[976] What's his new career again?

[977] He's on a committee that evaluates clinical trials for ethics.

[978] Wow.

[979] Which is what you want older people to do, use their wisdom and knowledge to be excited about something as well.

[980] Right.

[981] Something that stimulates you and keeps you going and gives you something to be interested in.

[982] And talk about wasting human flesh.

[983] What a wasted is, for someone with that knowledge to die prematurely.

[984] Right.

[985] That's the more interesting thing to me about longevity is, look, I'm so much wiser at 52 than I was at 42.

[986] I just am.

[987] I make less mistakes.

[988] I'm more aware just across the board.

[989] And I'm wiser at 42 than I was at 32.

[990] And at 22, I was basically a chimp.

[991] So it's like as time goes on, you understand how you're interfacing with the world.

[992] You communicate with people better.

[993] You know how to get by.

[994] You know what you have to do and what the consequences are of not doing what you have to do in terms of being disciplined and being healthy and just meditation and making sure you understand the consequences also of not doing the work that you're supposed to do in terms of like the way you feel about yourself, your self -respect and the way you just feel about.

[995] like your sense of self -satisfaction it's it to me it takes a big hit when I'm lazy takes a big hit when I don't get things done and I don't expect everybody to do the same things that I do or have the same sort of work ethic or none you know I don't I don't even say work ethics that implies like some sort of um superiority it's more of um just the idea of what you want to accomplish like your tasks everyone has their own idea of what but if you enjoy doing something and you're working towards something, I feel like there's more purpose to life.

[996] You have more satisfaction in accomplishing tasks.

[997] And that's one of the things that's been highlighted when you read books on happiness and studies on happiness.

[998] One of the things that seems to be most important is goal setting, goal setting, working towards those goals, and achieving progress.

[999] These are critical components to happiness for human beings.

[1000] And without them, there's this aimless sort of drifting of life.

[1001] people, for the most part, obviously everyone's different, but for the most part, people don't find satisfaction in just an aimless sort of drifting existence.

[1002] Yeah, 100 % I'm, I just turned 50 while I was over in Africa, or just before that.

[1003] You know, imagine being 80 and healthy, like my dad.

[1004] Or 90 or 100.

[1005] It just keeps getting better.

[1006] Of course.

[1007] Of course.

[1008] I'm so less stressed than I was in my 20s and 30s.

[1009] And anyone who's listening who's in their 20s and thinks that they're, you know, way better than a 50 -year -old.

[1010] I can tell you from experience, like you, Joe, when I was in my 20s, I thought I knew everything, or at least I looked at myself as a 50 -year -old, and I thought, what an old fart.

[1011] Yes.

[1012] Yeah.

[1013] It's not like that at all, especially with today's, you know, health and, you know, 50 -year -olds are just like they were, like a 30 -year -old was 20 years ago.

[1014] There was no 52 -year -olds like me when I was 20.

[1015] They didn't exist.

[1016] Maybe Jack Lillane.

[1017] Right.

[1018] Well, it's been talked about, I think it was the...

[1019] the New Yorker, that this movie cocoon, I don't know if everyone's seen it, but it's a pretty interesting movie where these 50, 60 -year -olds were given the fountain of youth, and they still look old, but it was really supposed to be quite funny to see these older people with gray hair jumping in the pool and acting 30 years old.

[1020] But a 50 -year -old isn't old anymore, 50 -year -old is just getting going.

[1021] Yeah, that's what's crazy about it.

[1022] You know, I mean, when they were like 50, they looked like they were dead men.

[1023] You know, like we were, we were looking at, I forget what the movie was, but it was a movie where I was like, how old was he when they made that movie?

[1024] It turned out he was 44.

[1025] I'm like, that guy looks 100 years old.

[1026] It looks like he's never worked out.

[1027] He probably smoked cigarettes all day long, never exercises, never, it drinks constantly.

[1028] This looks like a dead man. It's crazy.

[1029] Right.

[1030] So in the future, 90 will feel like 50 and 40.

[1031] Well, we were talking about Laird, earlier and laird i think is 55 years old and just as fucking fit as a human being can be and he's doing crazy shit where he's he's got this whole exercise routine that he does inside the pool where he brings like 70 pound dumbbells and he carries it with one arm and swims across the pool and the other you know he does two -handed dumbbell things the bottom of the pool and leaps the surface catches a breath of air drops back down to the bottom again leaps this surface why he's carrying these dumbbells i mean just ruthless, rigorous exercise at 55 years old.

[1032] Well, there'll be a time when you can't really tell how old somebody is, especially when we figure out how reprogram the body to be young again.

[1033] Yeah.

[1034] And it's going to be such a great world when people with 80 years of experience can continue to run companies and be teachers and educate the young people.

[1035] Now, there's a bias, though, against the elderly.

[1036] We've always had this in society, and we have to overcome that.

[1037] My dentist was biased against me as a 50.

[1038] You don't want to fix your teeth.

[1039] You're dead, bro.

[1040] I'm not fixed you.

[1041] It's worth the money.

[1042] Screw it.

[1043] I'll pay for it.

[1044] Just do it.

[1045] So crazy.

[1046] It was a 20 minute argument.

[1047] Do it.

[1048] 20 minutes.

[1049] It was a lot.

[1050] In fact, the time ran out and she said, fine, I'll do one tooth just to check.

[1051] Because she was, had all these reasons why it shouldn't do it.

[1052] It'll break off.

[1053] I have to polish back your original teeth.

[1054] And I said, look, I'm not going to get angry if it doesn't work.

[1055] Just try it.

[1056] And she did it.

[1057] And first of all, she said, I have to eat crow after it.

[1058] And then my wife came a week later and she said, man, your husband's a pain in the ass.

[1059] But he's on to something.

[1060] And actually, she's offering this as a service now to people our age.

[1061] Yeah, she's trying to make money.

[1062] I guess.

[1063] But it hasn't cracked off and I'm pretty happy with teeth that...

[1064] If it does, fix it again.

[1065] Right, why not?

[1066] We fix everything and we should do that.

[1067] But here's the problem with some aspects of medicine.

[1068] When we're young, we don't get the medicines that will prevent us getting sick when we're old.

[1069] So drugs like metform and you're not going to give to a 20, 30 -year -old.

[1070] Right.

[1071] But when you get old, you don't get the medicines that they give the young.

[1072] but everyone should be treated equally in my view as long as we know it's safe for sure you know there's the cost but some of these treatments like metformin that's probably less than a dollar a day a cup of coffee and might extend your lifespan where are you getting a cup of coffee for a buck i get free coffee from here from laird hamilton superfood machine but coffee's even more expensive than that yeah it's um the the limited idea of what you should or shouldn't do to fix people as they get older my friend uh got as eight ACL torn, and he's 60.

[1073] And he said his doctor recommended he just rehab it and don't get it fixed.

[1074] I go, what the fuck are you talking about?

[1075] Get it fixed, man. You want to have a bum knee that just buckles on you all the time?

[1076] Go get it fixed.

[1077] Six months later, it'd be done.

[1078] Like, you'll go through the rehab.

[1079] Otherwise, six months later, you still have a shitty knee.

[1080] It's like, your call, man, but I'd just get it fixed.

[1081] Bite the bullet.

[1082] Go fix it.

[1083] Right.

[1084] But his doctor was like, well, come on, Bruce.

[1085] Come on, Bruce.

[1086] Let's be honest.

[1087] We're at the end of the movie.

[1088] You're not 20 anymore.

[1089] Yeah.

[1090] That's that limited thinking is so frustrating to me. Yeah.

[1091] I first encountered this when I was 29, actually.

[1092] They were telling you at 29, it's a wrap?

[1093] Well, they were.

[1094] No, actually, this is the problem with the other end of the spectrum, which is I was too young to get a medicine that could help me when I get older.

[1095] Oh, wow.

[1096] This was cholesterol medicine, the statins.

[1097] And my doctor said, why do you want to get on this drug?

[1098] I know you've got high cholesterol, but you're only 29.

[1099] Come on.

[1100] And I said, look, why wait till I get the disease to treat it?

[1101] You know, now people use statins more, but in those days...

[1102] Aren't statins very controversial, though?

[1103] They are.

[1104] They apparently have a huge health hit.

[1105] Well, I haven't noticed, and I have high cholesterol, and I think it's worth it.

[1106] But, yeah, if there's nothing else wrong with you, you wouldn't take them.

[1107] But do you have arterial plaque?

[1108] No, not yet.

[1109] I'm perfectly clean.

[1110] Right, but shouldn't...

[1111] But isn't there's some...

[1112] There's doctors that are arguing that the idea of high cholesterol, where it's LDL, HDL, whether it's good cholesterol, bad cholesterol, this sort of uniform approach, people with high cholesterol need to take something that lowers their cholesterol.

[1113] And doctors that I've talked to are saying, well, not necessarily.

[1114] You could be incredibly healthy, especially if you're not sedentary, with relatively high cholesterol if everything balances itself out.

[1115] If you have the appropriate ratio of HDL to LDL, do you have the appropriate ratio or is it out of whack?

[1116] Now I do.

[1117] But when I was 29, I was off the charts.

[1118] I had blood that looked more like cream.

[1119] And that's where one of the things apparently where dietary cholesterol does make a hit, it does have an effect on people with genetic predisposition to high cholesterol in certain ways, right?

[1120] Is that correct?

[1121] Right.

[1122] Yeah.

[1123] Right.

[1124] But changing my diet had a big impact as well.

[1125] What did you do that was different?

[1126] I went more, well, I ate less.

[1127] I lost weight.

[1128] That helped.

[1129] Do you do intermittent fasting?

[1130] Yeah, as much as I can.

[1131] One of the other guys that was on this tour of Israel with me is Volta Longo, and he's arguably the world's expert on this.

[1132] What a great name.

[1133] Isn't it?

[1134] He's an Italian guy.

[1135] Volta Lungo.

[1136] Longo.

[1137] Yeah, like the coffee.

[1138] Sounds like a guy you call in when you got a real problem.

[1139] You know?

[1140] Uh, yeah.

[1141] Well, he's, uh, he's written a book and he is the probably world's expert in human periodic fasting.

[1142] Here's, for everyone who wants to know about what the best periodic fasting, uh, protocol is, there isn't one.

[1143] We don't know yet.

[1144] We're right on the cost.

[1145] There haven't been enough studies, but there are a few types.

[1146] Um, I go through them in my book.

[1147] So, because we won't have time to go through all of it.

[1148] But there's, uh, the, uh, what is it, the 18, 18 hours.

[1149] Yeah.

[1150] If you can go skip breakfast, have a late lunch, that's a good start.

[1151] That's what I try to do every day.

[1152] It's not always possible, like, when you're in Africa and they're feeding you massive meals three times a day.

[1153] But that's what you want to do.

[1154] Be hungry for a part of the day.

[1155] Or you can go a little more extreme and skip two days a week.

[1156] And what's the benefit of being hungry?

[1157] Great question.

[1158] And this is what my lab and others figured out in the first few years of the 21st century.

[1159] We figured out that these genes that extend.

[1160] lifespan.

[1161] These Sertouin genes are activated by being hungry, in part by raising NAD levels, which NMN will mimic the effect of.

[1162] So being hungry actually raises your lifespan in some sort of way?

[1163] Right.

[1164] So caloric restriction is what we used to talk about a lot.

[1165] If you restrict the calories of a rat, it was actually discovered back in the early 20th century, we'll make them live up to 30 % longer, not in an old state, but it prevents them getting old.

[1166] So the rats don't get cancer, heart disease, and all of these other good things.

[1167] And that was the only thing that we knew up until about 20 years ago, even 10, probably.

[1168] And so we used to think you had to be hungry all the time.

[1169] And there was a, still is a society called the Calorie Restriction Society.

[1170] And they were hungry all the time.

[1171] They had very small meals, which is pretty tough.

[1172] I tried that and gave up after a week.

[1173] But this new paradigm is that you don't have to always be hungry.

[1174] similar to you don't always have to be on a treadmill.

[1175] You can do it for a short time, make it intense, and then you can let your body recover and go back to a normal life for a little bit.

[1176] And that's great news.

[1177] That means that we can have our cake and eat it too, so to speak, as long as the cake doesn't have a lot of sugar in it.

[1178] Now, when you are on this protocol of restricted eating plus metformin, when do you take what and when do you exercise and how do you do you?

[1179] balance it out like what when do you know what to do what uh i use my body as a guy you know now that i'm 50 i have a pretty good like you you know you know how your body feels and reacts i'm also measuring it uh a ring that that uh measures my pulse and my sleep is that the aura yeah yeah how do you spell that a oh u r yeah is that uh isn't kevin rose a part of that company is that is that is that yeah jami says yeah okay from dig you know dig dot com you don't No, Dig?

[1180] No, I'm high -laws.

[1181] How dare you?

[1182] Sorry.

[1183] It's a good place to go find cool shit.

[1184] Okay, I'll go there.

[1185] Dig .com.

[1186] Shout out to Dig.

[1187] Yeah, I go there every day.

[1188] Because real interesting stories on the Internet.

[1189] You're always finding cool, weird videos and just fascinating science stories, human nature, human interest stories.

[1190] Sounds good.

[1191] I have a watch.

[1192] What kind of watch are you using?

[1193] The Apple Watch.

[1194] Okay.

[1195] How does that measure it?

[1196] By the way, they just released Apple Watch 5 today.

[1197] Ooh.

[1198] apparently it's better.

[1199] You might want to get it.

[1200] What does it do?

[1201] What does the Apple Watch do?

[1202] Yeah, like, how's it?

[1203] Well, it changes songs in my head from this.

[1204] Tells the time occasionally.

[1205] But yeah, what's useful with it is pulse and activity.

[1206] And if I haven't moved enough during the day, I've got a standing desk and that's been helpful to make me move around a little bit more.

[1207] But mainly it's, and I also do occasional blood test to make sure that my body's optimized as best.

[1208] I can, personalized.

[1209] And using all those measures.

[1210] You read the data off your watch?

[1211] Like, how do you read it?

[1212] What application are you using?

[1213] Nothing special, just on my phone, have a look.

[1214] Okay, so you just have a look like what your resting heart rate is, how much activity, how far you're walking, how many calories you're burning, that kind of deal?

[1215] Yeah, yeah, pretty simple.

[1216] And I'm happy to say my resting heart rate's really low, which means, you know, things are going okay so far from me, even though I don't do enough exercises you rightly, point out, I think my resting heart rate's 46.

[1217] That's very good.

[1218] It's pretty amazing for a guy that barely does exercise.

[1219] Yeah, you must have good genetics.

[1220] Well, obviously, you do your dad's in phenomenal shape at 80.

[1221] No, we have terrible genetics.

[1222] Well, how's he in such great shape at 80?

[1223] Well, we don't know.

[1224] But it could be that he's been exercising and he's also been on this paradigm.

[1225] So one of the effects in mice at least of NMN, which is what we're taking is improved blood flow.

[1226] you get the benefits of exercise without having to exercise if you're a mouse.

[1227] And those mice, they were running on a treadmill for 50 % further because the blood flow and the lactate was reduced.

[1228] Really?

[1229] So maybe that's happening with that.

[1230] That's incredible.

[1231] Now, what is the difference between the effects of NMN and IVNAD, which is very popular?

[1232] There's people that take IVNAD, and I've never done it, but we've talked about doing it many times and having it brought in here and sometimes people do it and they do it very quickly where you do it it only takes 10 minutes but it hurts like hell apparently it gives you like stomach knots and you feel terrible right all right have you done it i haven't admitted publicly that i've done it um do it but i but i try everything once pull up that microphone i try everything once yeah and uh so last time i was out here in l -a i gave it gave it a shot so to speak yeah how was it it was fine it was fine now let's get to the science in a minute but what I found was so it was a shot in the butt with some AD so why didn't they do it intervenously I thought that was the mood they did it intramuscularly right right this doctor is experimenting oh Jesus yeah it was it was a friend of a friend so I had a I got an idea come here yeah but here's the thing it felt I had tingles in my legs I felt a little different for a few minutes, maybe 10 minutes, and then it went away.

[1233] But the science, we don't know yet.

[1234] We're still trying to figure out if that actually works or not.

[1235] So instead, I'm taking the molecule that we've studied in my lab, which has taken as a pill.

[1236] Now, there are a lot of people that swear by the IV version of NAD, and when they do it intravenously, apparently you feel phenomenal.

[1237] And there's quite a few people I know.

[1238] My friend Kyle Kingsbury has done it several times.

[1239] and he's very big on the latest and the greatest of health crazes.

[1240] Well, I know it's being used widely, especially down in Florida, to treat addiction.

[1241] NAD.

[1242] Interesting.

[1243] And I get emails all the time, which is best.

[1244] But, you know, I'm a scientist.

[1245] I'm at Harvard Medical School.

[1246] So I have to always be based on facts.

[1247] And the fact is we don't know if it works yet.

[1248] Right.

[1249] My father's story is not a clinical trial, right?

[1250] We need to do more.

[1251] But what's interesting about this field is.

[1252] is that because people have accessed information through podcasts like yours and through the internet now that papers, you can go to what's called PubMed Central and find papers, people educating themselves just like scientists used to, and they can go to the doctor or go to the internet and try experiments on themselves.

[1253] Now, I don't condone that.

[1254] I can't.

[1255] I'm a researcher, not a doctor.

[1256] But I find it really interesting that we're in a new phase of society, where people can learn more in many cases than their doctors actually know sure in particular when it comes to nutrition because that's one of the things that i found it's shocking when you talk to some doctors and you talk to them about nutrition particularly supplementation and they'll say things like well you can get everything from a good diet like can you really can you really like how much time did you spend school motherfucker like how much time did you study nutrition this is nonsense talk you can get everything from a good diet what's your good diet tell me what a good diet is right what do you getting from that good diet?

[1257] How are you getting that vitamin B12 in high doses?

[1258] What are you getting?

[1259] Where are you getting your D3?

[1260] What are you getting?

[1261] Huh?

[1262] Where are you getting your essential fatty acids?

[1263] What's the optimal level of essential fatty acids?

[1264] And they don't have a fucking clue what they're talking about.

[1265] You know, there's so many doctors that go through their entire medical, you know, orthopedic surgeons or what have you.

[1266] They go through their entire medical school with like maybe four or five hours of nutrition research.

[1267] Right.

[1268] I have to be careful what I say.

[1269] I work at the medical school.

[1270] I love doctors, don't get me wrong.

[1271] Right, we need them.

[1272] We're not going to do surgery on ourselves.

[1273] Right.

[1274] That said, some doctors will listen to their patients and do research.

[1275] Those are the great doctors that actually stay on top of things.

[1276] But it's really hard, right?

[1277] They're already working 12, 14 hours a day.

[1278] So let's be fair to doctors, plus they have to work within the insurance system.

[1279] I understand that.

[1280] The only problem that I have is when they say things like, you get everything you need with a good diet.

[1281] You remember three square meals a day.

[1282] That's bullshit, too.

[1283] Make sure you follow the food pyramid.

[1284] eat a lot of grain.

[1285] Right, right.

[1286] Yeah, remember that?

[1287] Well, and don't eat eggs, don't drink milk.

[1288] Hilarious.

[1289] Yeah.

[1290] Eat margarine.

[1291] Yeah, hilarious.

[1292] Well, milk is a sketchy thing, quite honestly, because you're drinking this dead liquid.

[1293] It's been homogenized and pasteurized, and I find my body reacts very differently to raw milk than it does to milk that has been processed.

[1294] Well, I wonder if anyone studied the microbiome that might be helpful, too.

[1295] It just makes sense that it's got all the enzymes in it.

[1296] That's how the human being or a body, any animals, supposed to naturally process that milk.

[1297] Yeah, I guess it's mostly sterile.

[1298] Yeah.

[1299] But, yeah, I use whole milk in my day.

[1300] It's surprising, right?

[1301] Because I'm trying to avoid calories.

[1302] But the benefits in the taste and how I feel, that yogurt, I make myself out of whole milk.

[1303] You make yogurt?

[1304] Yeah.

[1305] What are you, a wild man?

[1306] Why don't you buy it?

[1307] You're so short on time.

[1308] What are you doing?

[1309] What are you making your own butter to you?

[1310] You got one of them churners?

[1311] yeah well you know we all have our hobbies one of my hobbies that's your hobby not really that's a cool hobby no here's the problem uh i got so hooked on this type of yogurt which i first made for my son uh trying to help him he has a weight and eating uh issue i was thinking that would help him uh but i got addicted to the yogurt and so is everyone in my family now so if i don't make the yogurt they're like dad where's the yogurt oh no kidding so how do you do it oh it's really easy you get packets there's three different packets you rip them open put them in whole milk shake it and stick it in the the oven on on de -frost for 24 hours really on the in the oven so what is de -frost like what temperature is that it's uh 35 celsius whatever that is it 95 is that 90 95 so you're using like a dutch oven or something like that that's regular oven but i mean in terms of the pan that you put oh oh what you mean what's the bottle yes it's just a at large i think mason Okay.

[1312] And just heating it up with the probiotics inside of it, the bacteria inside it, it just starts to coalesce?

[1313] Yeah, and I've perfected it.

[1314] The first few ones were not great, but now it works every time.

[1315] And actually the protocol on the internet said you have to boil it, measure the temperature, get it all right, sterilize it.

[1316] And I just pour it straight in, shake it, stick it in, it's fine.

[1317] Really?

[1318] Yeah, so far.

[1319] Huh.

[1320] Did you ever get it analyzed?

[1321] No. No, but you're a scientist.

[1322] You don't want to send it a little cup of it to somebody?

[1323] You go, hey, man, take a look at this.

[1324] What are you worried about?

[1325] I'm not worried.

[1326] I'm not worried at all.

[1327] I'm just curious as to how potent it is.

[1328] You know, there's various levels of, you know, acidophilus that you're getting from yogurt.

[1329] Yeah, I researched it before I started, and this is a company that makes a yogurt that matches a healthy microbiome.

[1330] It's the only one I'm aware of.

[1331] That's great.

[1332] And you use whole milk.

[1333] You don't use raw milk.

[1334] Right.

[1335] I don't have good access to raw milk.

[1336] Where do you get it?

[1337] Like a health food store, like sprouts or, you know, something like that.

[1338] I should try that.

[1339] Yeah, I think they have it at Arawan.

[1340] Maybe Whole Foods has it.

[1341] It's like, it's really tricky because you, it's not even legal in some places to have whole milk.

[1342] In fact, people have been arrested and just locked up for having whole milk.

[1343] Yes.

[1344] Google that, because it's pretty preposterous.

[1345] think about how easy it is to buy whiskey, right?

[1346] And then think about people buying whole milk.

[1347] That whole milk is apparently for some people.

[1348] I mean, it might have just something to do with skirting FDA regulations and things along those lines.

[1349] It gets very complicated for sure.

[1350] And then there's a, the reason for homogenization and pasteurization is obviously health, right?

[1351] We're trying to protect people.

[1352] And also, it's shelf life.

[1353] It stays on the shelf longer.

[1354] But I've definitely bought it.

[1355] Yeah, there's a small, what does it call it, a small group, food group, raw food club.

[1356] They were raided in 2011 for sharing raw milk or something.

[1357] The latest raw milk raid, an attack on food freedom?

[1358] Federal agents organize a sting operation against a tiny raw milk buying club and ignore more serious food safety concerns.

[1359] Yeah, like Twinkies?

[1360] I mean, how hard is it?

[1361] Look, you can, I'm sure, get food poisoning from spoiled milk, right?

[1362] But isn't spoiled milk yogurt ultimately, right?

[1363] Well, here's what I do with food.

[1364] If it stinks, I don't eat it.

[1365] Good move, bro.

[1366] Yeah.

[1367] And I think milk, you smell pretty quickly if it's going bad.

[1368] This involved unwashed room temperature eggs.

[1369] The other count.

[1370] Unwashed room temperature eggs.

[1371] A storage method, Rossum members prefer.

[1372] By the way, when we had chicken.

[1373] for these nasty coyotes, killed all my chickens.

[1374] We would store our eggs at room temperature.

[1375] We'd put them in a bowl.

[1376] We would wash the outside of the egg and put them in a bowl and they would sit on the counter and I was eating them all day long.

[1377] Nothing happened.

[1378] Healthy as fuck.

[1379] Asians dumped gallons of raw milk and filled a large flatbed with the seized food, including coconuts.

[1380] We seized your fucking coconuts.

[1381] Watermelons and frozen buffalo meat.

[1382] What the fuck?

[1383] like what is this agents who who are these assholes that are getting paid government money from our taxes to steal frozen frozen meat Jesus Christ Christopher Darden who helped prosecute O .J. Simpson appeared at Stewart's arraignment just in time to lower his bail all right so Christopher Darden's out there helping people whatever gross it's just a gross I mean I don't think you should you know we should somehow or another find out whether there's a way to test if this raw milk is fresh enough for people to eat but if it is people live on farms have been drinking raw milk since the beginning of time it's normal and healthy it tastes better it's it's way easier for you to digest like uh i get a little weird when i drink like straight like if i have milk and cookies which i love um i don't know Maybe it's the cookies or milk.

[1384] Hmm, I might be full shit here.

[1385] Now I'm thinking about it, the cookies might be what's messing with my stomach.

[1386] I don't think so, though.

[1387] Because you get this feeling from the milk like the little, it's probably both.

[1388] Now that I think about it, it's both.

[1389] Well, in France, you get the unposterized cheese.

[1390] Yes.

[1391] My friend Jean -Marc used to bring it back in his luggage.

[1392] He would smuggle back for a rock lot.

[1393] You know what that is?

[1394] Yeah.

[1395] It's like a dish that he would make.

[1396] with meat and cheese.

[1397] Yeah, that's good.

[1398] But I don't hear the French dying in droves either.

[1399] They seem to be healthy as fuck.

[1400] And they're not as fat.

[1401] Right.

[1402] Yeah.

[1403] Their bread is better.

[1404] They have bread that is not from, they don't have modern wheat.

[1405] So the wheat that they have is not engineered to have more complex glutenes and higher yield like we do.

[1406] So we don't buy bread in my family.

[1407] My wife makes it.

[1408] Oh, nice.

[1409] And so we, sourdough?

[1410] Yeah.

[1411] A lot of sourdough.

[1412] The yeast is even wild.

[1413] She got that from Belgium.

[1414] A friend of ours hung some yeast, what is it?

[1415] Some stuff in a tree, collected the yeast, brought it back to the US and shared it with us.

[1416] Caught it?

[1417] Like caught some yeast?

[1418] Well, he put some wet dough up in a tree and left it there for a few days and caught this wild yeast up in the Belgian forest where apparently it only occurs.

[1419] He claims.

[1420] But we have the best bread at home.

[1421] It's crunchy.

[1422] You know, you're crunch.

[1423] crack on it, you break it open.

[1424] I mean, I'm trying to avoid carbs, and this is the hardest thing when you get home and the breads just come out of the oven.

[1425] Why are you avoiding carbs?

[1426] Well, I'm trying to keep my blood glucose levels steady, not spike too much.

[1427] That's pretty clear that that's not healthy.

[1428] And just eating a bunch of bread will be a good way to spike that.

[1429] One of the things that I've heard about the French and Italians in general is that they eat their bread with either butter or olive oil, and that these healthy fats that you're getting along with the bread is one of the reasons why it doesn't have the same sort of health hit.

[1430] And then the complex glutons, you know, the engineered wheat that we have.

[1431] When you eat pasta in Italy, it has a different effect on your body.

[1432] It just feels different.

[1433] Yeah, exactly.

[1434] So there are a number of people that I know, maybe people you know, too, who are putting glucose monitors on their arm here to see what foods they react to.

[1435] Rodder Patrick's been doing this for a while, and actually I asked her, what about, what's the worst food you've seen in your body to spike glucose?

[1436] She said, grapes, avoid grapes.

[1437] Really?

[1438] Yeah.

[1439] Avoid grapes.

[1440] Yeah, I wish I hadn't asked to that.

[1441] So now I'm so counterintuitive, right?

[1442] You think you're eating healthy when you're having some fruit.

[1443] As I said, what was the biggest surprise?

[1444] She said, potatoes aren't so bad.

[1445] Well, there's a thing that you could do with potatoes, right, where you boil them and then cool them off and then reheat them.

[1446] And apparently have has a profound effect on the way it impacts your blood sugar levels.

[1447] That it's far healthier when you, there's some sort of a process.

[1448] See if you can find out what that process was.

[1449] Who explained that to us?

[1450] Do you remember, was it Rhonda?

[1451] Probably was.

[1452] 99 % of my nutrition knowledge I get from Rhonda Patrick.

[1453] But I believe it's something to do with the way the potato reacts to being boiled and then chilled and then reheat it again.

[1454] There's something about it.

[1455] So the starches are less available somehow?

[1456] Somehow.

[1457] And it has a much more healthy effect on your blood glucose levels and doesn't spike you in the way that just a straight up baked potato would.

[1458] This would be coming from Chris Cressor.

[1459] Aha, even that's the other 1 % of my nutrition knowledge.

[1460] It's probably not, it's probably like 6040.

[1461] Potatoes for gut health and weight loss, the potato hack says, The potato intervention is a short -term tool to check the reactivity of the gut to resistant starch.

[1462] Reset the hedonic system, create metabolic flexibility, resolve inflammatory conditions, and provide the patient with an empowerment tool to increase the fat loss of their dietary plan.

[1463] It's not meant as a standalone diet, but rather a dietary tool to decrease hunger.

[1464] Blah, blah, blah, blah, blah, blah, blah, blah.

[1465] Scroll up there so we can find out what the fuck the potato hack is.

[1466] Explanation.

[1467] Poor potato has been maligned.

[1468] Here's an explanation of functional medicine, Chris Crescher, on the Joe Rogan Show.

[1469] Ha!

[1470] Right here.

[1471] Who that?

[1472] Scroll up.

[1473] Magic of this plan leads its clinical effect efficacy is the amount of resistant starch.

[1474] Resistance starch is a type of starch, that is, indigestible to us but feeds our microbiome.

[1475] When a potato is heated and then cool, the significant amount of its starch is retrograded into resistant.

[1476] starch.

[1477] This means that the effect on blood sugar is greatly dampened.

[1478] The potato can be reheated and it will still retain its resistant starch content.

[1479] The nourishment to our gut biome and the subsequent metabolic benefits cannot be overstated.

[1480] I've seen this be crucial in some patients who have stalled on a low carb or keto eating plan but still have significant body fat left to lose.

[1481] Historically, resistant starch would have been present in most roots, tubers, unriped bananas, plantains, etc., but is often devoid in our current diets.

[1482] Chris Crasher in the house.

[1483] Yeah, so there you go.

[1484] So when I was in Africa, you reminded me, they eat a lot of blueberries.

[1485] And so these colored foods are also good to eat.

[1486] So resveratrol comes on when yams, dark things, right?

[1487] it beats.

[1488] Well, yeah, leafy vegetables, but also fruits that are very colored.

[1489] Colorful.

[1490] So why is that?

[1491] Why is that?

[1492] Well, I'm glad you asked.

[1493] So we have this idea called Xenor Hermesis, and it's a terrible name for something that's quite simple, and that is that these molecules from plants are produced to make the plants healthier.

[1494] These are stress response, chemicals.

[1495] And with you stress plants, they turn colored, turn on a UV lamp, or put a plant in the sun, it'll turn reddish, you know.

[1496] Those are stress chemicals to survive.

[1497] And I believe that we've evolved to sense those chemicals in our food supply.

[1498] Oh, so we're attracted to juicy red tomatoes, as opposed to pale tomatoes.

[1499] But not just a flavor.

[1500] I think we're attracted to it because they're colorful.

[1501] But what our bodies get out of it is that these chemicals go into our bloodstream and they turn on our defenses against disease to survive.

[1502] Why is that good?

[1503] Why did that evolve or potentially evolve?

[1504] It's, I think, because when our food supply was stressed, we need to get ready for adversity, because we probably run out of food.

[1505] And if you're a bird or some other dumb animal, dumber animal, or even a yeast cell, how are you going to know if your food supply is going to run out?

[1506] You've got to know it chemically.

[1507] So these chemicals are a heads up, that adversity is coming.

[1508] So if you eat a lot of these chemicals through, say, red wine, which is stressed grapes and other things like that, blueberries, these chemicals, they're not probably not working.

[1509] mainly through antioxidant activity, they're giving us this stress heads up.

[1510] Isn't there, there's, that's a controversial thing, the red wine thing, correct?

[1511] Like whether or not red wine, the, the actual compound of resveratrol is where we're getting our benefit from because it's apparently a very small amount of reservoir and red wine?

[1512] Yeah, sure.

[1513] It's not really controversial except when people exaggerate and say that it's all reservoiratrol.

[1514] Resveratrol is a component of dozens of healthy molecules in red wine.

[1515] Quercetin, which is good for a number of things.

[1516] There's a whole bunch of polyphenols, they're called.

[1517] And so resvertrol is part of that cocktail.

[1518] Is this due to the fermentation process?

[1519] Because we're talking about grapes themselves with the high sugar content, actually being something we should avoid, right?

[1520] Right.

[1521] So don't eat the grapes.

[1522] But wine, if you don't have too much of it, will have a concentrated amount of these xenohrometic molecules like Rosveratrol and quercetin.

[1523] Is this a parent in red wine?

[1524] It's really only in red wine.

[1525] So white wine is just for chicks, right?

[1526] Not as healthy, not as healthy.

[1527] Actually, that's a joke for my friend Bud.

[1528] Yeah, you'll get in trouble for that one.

[1529] No, it's just for my friend, bud.

[1530] He always loves white wine.

[1531] I'm like, that's for chicks, bro.

[1532] I'm joking, folks.

[1533] Just jokes.

[1534] Don't get it touchy.

[1535] Yeah, so you don't need to, so when we treated mice with resveratrol, they were immune to the effect of a high -fat diet, Western diet.

[1536] And we've traced this down to a single genetic pathway that we work on these Sertuans I talked about, these NAD responsive pathways.

[1537] Really?

[1538] So they were immune to eating shitty food, like the negative aspects of eating shitty food?

[1539] Yeah, this was 2003.

[1540] That's why it hit all the newspapers, because it was the first molecule that was safe and could mimic the effects of fasting or caloric restriction without actually having to be hungry.

[1541] Wow.

[1542] And what kind of dose are you giving these mice?

[1543] It was the equivalent of about 250 milligrams a day in a human.

[1544] Okay, so it was one quarter of what you recommend people take.

[1545] Right.

[1546] I don't recommend people take anything.

[1547] Okay, what you take, right?

[1548] Let's just say that.

[1549] No recommendation, sorry, folks.

[1550] Yeah, I'm taking a higher dose because I've looked at human clinical data, and I think that a higher dose may be required to have an even better effect on longevity.

[1551] but the results were very clear when we opened up these mice maybe I shouldn't have said that when we examined those mice carefully put them to sleep for scientific purposes it was clear that they were healthier now they were still fat that was interesting they were still fats we figured the experiment didn't work but their arteries were clean their livers were like a healthy lean young mouse and when we looked at their metabolism it was like a younger mouse so let me ask you this then because you take statins if you are fairly convinced because the research of the positive benefits of resveratrol in healthy aging and healthy metabolism and their arteries why you take in statins because you know that there are some negative effects of statins right well if i had five lifetimes i'd probably try that experiment but i don't want to you just don't want to risk it yeah is there enough i mean have you looked through the papers the research papers on on statins and a little bit there is some correlations with dementia and the brain does need cholesterol so that might be one of the problems is your dad on statins yes really we have a whole bunch of genes that predisposed 23 me said basically give up now wow it's pretty horrible so yeah if I make it to 80 I'm doing pretty well damn interesting because Bourdain when he was alive he had made a decision to take statins versus change his diet.

[1552] This is before he got into jih Tzu.

[1553] When he was traveling the world and eating the finest foods and drinking wine to excess every night and enjoying the shit out of it, you know, we had a conversation about it.

[1554] He's like, I would rather eat well.

[1555] He said, I'd rather eat well and take these drugs.

[1556] He goes, I know the side effects.

[1557] I know they're dangerous.

[1558] So then we have a conversation maybe two years later, he gets really into jiu -jitsu.

[1559] His wife at the time was into Jiu -Jitsu, and, you know, she had convinced him to try it, and he went and tried it and immediately got hooked.

[1560] And he has, or he had an addictive background, you know, first was heroin and, you know, some other unfortunate substances, and then, you know, cigarettes for a while, he quit that, and then Jiu -Jitsu became his new addiction.

[1561] And he got ripped.

[1562] I mean, he really, I think he started training.

[1563] at 58 or 59 he started and then by the time he was 62 he had a full six pack it was crazy to see like I'm like look at you man this is nuts like this is an image of him walking down the street and I mean he has no shirt on and he's fucking shredded got off all the statins got off everything has changed his whole his issue with cholesterol yeah good on him just through daily exercise yeah I should try yeah you should yeah a little bit of shame that I haven't been able to get off the statins, but they just scare me, man. I've just read too many things.

[1564] Well, you know, I could have gone off them when I was on a really lean diet.

[1565] I tried this Okinawa diet from Okinawa.

[1566] Okinawa, yeah.

[1567] So just fish mostly and, and tofu.

[1568] Hmm.

[1569] How did that go?

[1570] I was great, but then I had kids.

[1571] Oh, you can't feed tofu to kids every day.

[1572] Right, but you can't have separate food just for yourself.

[1573] I'm not going to just, no. I understand.

[1574] Yeah.

[1575] Well, you're, yeah, that's the thing is like you're, you're, so limited by time.

[1576] You know, you have such an involved research schedule and life schedule and travel schedule.

[1577] Yeah, I'm a pretty average guy.

[1578] I'm not militant about what I eat.

[1579] I try my best every day to do what I can.

[1580] But this statin thing, I just haven't had the chance to do it.

[1581] But resvertrol, I don't think, is sufficient to keep these cholesterol levels down.

[1582] So combination so far.

[1583] When you first got on the, how long you've been on statins?

[1584] Since 29.

[1585] Oh, wow.

[1586] So you really have been on them for 21 years.

[1587] Not only that, super high dose.

[1588] So it's 80 milligrams.

[1589] What's a normal dose?

[1590] 10.

[1591] That's crazy.

[1592] Yeah, my doctor, one of the best at Harvard, looked at my genetics and said, you're fucked.

[1593] Wow.

[1594] Yeah, I've got all the wrong genes.

[1595] These tiny little lipoprotein particles, the ones that oxidize.

[1596] So the fact that my arteries apparently clean is good news for me. Well, that's good news.

[1597] Like I said, you look good.

[1598] Oh, thanks.

[1599] I mean, obviously, there's a lot biodiversity when it comes to human beings and some things that are bad for others good for some well i'm not losing my mind yet still a pretty functional when it starts slipping away what are you going to do ask your wife or your friends or what are you going to do yeah what am i going to do what if your dad's want to tell you yeah that could happen right he's 85's like yeah my dad's sit down yeah david you ask me the same question three times in a row the way it's going that could definitely happen well do you get a lot of sleep uh i do now now that i'm monitoring it yeah what's a lot of sleep for you uh between six and seven hours oh that's good the doctor matthew walker um was a guy that i had on my podcast who studied sleep and he was fascinating and it changed my entire opinion about what's necessary there's a direct correlation between limited amounts of sleep and alzheimer's direct correlation he's like it's one of the most established links that you can see between a disease and a cause.

[1600] I'm misquoting it.

[1601] It's an association.

[1602] I'm a scientist.

[1603] I always have to be skeptical as to whether if you're predisposed Alzheimer's, you have trouble sleeping.

[1604] Oh, interesting.

[1605] And you start taking Ambien.

[1606] Now people say, well, Ambien and Alzheimer's are correlated.

[1607] Well, yeah, maybe it's the other way around.

[1608] Yeah, Ambien scares a shit out of me. You don't take that, do you?

[1609] Tiny bits.

[1610] Oh.

[1611] Oh, that stuff's nuts.

[1612] Because people take it and they say things and they don't know what they're saying.

[1613] Right.

[1614] Well, the recommended dose, at least it used to be for men, is 10 milligrams, which is massive.

[1615] I nibble on it.

[1616] I take maybe a milligram just to nod off if I'm desperate with jet lag.

[1617] But yeah, doctors, many I know say that 10 milligrams is probably too high.

[1618] But check with your doctor.

[1619] Yeah, well, Matthew Walker says, stay the fuck away from that stuff, period.

[1620] He said, you're not getting real sleep anyway.

[1621] You're not going in through full sleep cycles.

[1622] you're just drugging your brain into a state of unconsciousness.

[1623] Probably with 10 milligrams that makes sense.

[1624] For me, because I'm monitoring it, I know that I'm getting good deep sleep.

[1625] Have you tried other like melatonin things along those lines?

[1626] Sure.

[1627] Not effective.

[1628] Not as much.

[1629] Sometimes melatonin with a milligram of ambient as necessary.

[1630] But a big change for me has been just don't stay up watching TV, get the screens off.

[1631] Yeah.

[1632] Glasses.

[1633] They really help.

[1634] Yeah, the screens are.

[1635] Watching those goddamn screens before you go to bed.

[1636] I love doing it, though.

[1637] I love watching a TV show before I go to sleep.

[1638] It's probably the worst time to do it, though, right?

[1639] Yeah, it is.

[1640] It really.

[1641] I mean, you can watch the shows.

[1642] Just put the yellow glasses on.

[1643] Like blue light emitting, yeah, blocking glasses.

[1644] One of my sponsors, movement watches.

[1645] They have blue light emitting glasses.

[1646] You need to get those, huh?

[1647] Blocking or emitting.

[1648] Blocking, blue light blocking.

[1649] Yeah.

[1650] Yeah, not emitting.

[1651] How can a glass emit, you know, blocking blue light emitting sickness?

[1652] Yeah.

[1653] Well, you can have blue light emitting glasses, too.

[1654] That'd be good.

[1655] Really?

[1656] Well, for the middle of winter.

[1657] Oh, if you're getting depressed.

[1658] Yeah.

[1659] Well, where you live.

[1660] Right.

[1661] There's no real middle of winter here, buddy.

[1662] Where you used to live, too.

[1663] Yeah.

[1664] Not too far from where I lived.

[1665] Yeah, it's pretty tragic.

[1666] Middle of winter, I want to kill myself.

[1667] Do you get that seasonal affected disorder?

[1668] Oh, for sure.

[1669] Yeah.

[1670] Yeah, because I'm working indoors.

[1671] I don't see sun for months.

[1672] Well, that gray sky, when it's every day's gray, over and over again, you see no real sky for so long.

[1673] It's so weird.

[1674] Yeah, I miss Australia for that reason.

[1675] I get reinvigorated if I come out to L .A. and there's blue sky.

[1676] You really feel different.

[1677] Oh, for sure.

[1678] There's a reason why there's a fucking billion people out here.

[1679] But what is your strategy for mitigating the impact of seasonal affected disorder?

[1680] what I do.

[1681] I try to go outdoors and get some sun in my eyes when I can.

[1682] Do you take vitamin D?

[1683] Oh, for sure.

[1684] Lots of vitamin D. I seems to have helped.

[1685] Make a difference.

[1686] Yeah, yeah.

[1687] So, yeah, vitamin D, it's questionable, whether it's as healthy as people thought it was.

[1688] That said, I think it, at worse, doesn't hurt you.

[1689] Some people do sun lamps for that reason.

[1690] They'll go into a tanning booth for that reason, right?

[1691] they will actually found this season i went to the sauna in the cold shock bath and that really helped a lot i don't know if it's related but uh i needed to shock my body in the middle of winter if you're just sitting by a fire and barely moving around i just felt like it was a sack of shit and so yeah a lot of people get fat in the winter too that's another thing they just they get indoors because it sucks outside they never wind up doing anything and then you're dealing with the depression of being a little bit heavier too Oh, for sure.

[1692] And then you're drinking by the fire, all that kind of stuff.

[1693] But it's all about shock your body, get your body out of complacency.

[1694] And our lifestyle, everything we do, everything we buy, everything on TV that's being advertised to make your life better is shortening your lifespan by making it easier for our bodies to exist.

[1695] You don't want that.

[1696] You've got to stress it.

[1697] Yeah.

[1698] What other things do you think that people should be doing on a daily basis that most folks aren't?

[1699] well we covered a lot um so there's the the be hungry get the exercise uh there's all sorts of exercise which are good but the main ones are stretching and running and uh lifting okay uh cold and hot we've talked about um and then there's the supplements that mimic the benefits of those plus probably more things that's my that's my uh regimen there's some other little tidbits that i put in my book which it's a laundry list of things that i found work for me, but those are the main things we've covered.

[1700] This sounds probably pretty boring, but I'll say it again.

[1701] We're sunscreen?

[1702] For two reasons.

[1703] I mean, you'll look better anyway.

[1704] Not that probably young people care, but it'll make a difference by the time you're our age.

[1705] But also, because DNA damage does age you, we think that it's breaking the chromosomes, and that's the major driver of aging.

[1706] That sun will do that, x -rays will do that, maybe even.

[1707] Airport scanners are certainly, I'm not a devotee of getting scanned.

[1708] I thought there were radio waves.

[1709] They're millimeter, and they don't penetrate very deeply, so they're probably not too bad.

[1710] But I've looked into it.

[1711] It's about the same radiation as you get on the flight, and given that I'm doing probably a million miles a year, I don't want to double the amount of exposure.

[1712] So when you go through that radio scanner, then the more modern TSA scanners, they give you the same amount of radiation as a flight?

[1713] Because a flight gives you the same amount of radiation as multiple x -rays.

[1714] Right?

[1715] I don't think it's that bad.

[1716] I believe it is.

[1717] Well, let's find out how much radiation do you get on a five -hour flight and is it comparable to multiple x -rays?

[1718] Because I believe that's what I read.

[1719] Well, the x -rays, I can say definitively, based on our research, would aid you.

[1720] Age your tissues.

[1721] What's it doing to you?

[1722] Well, it's breaking your chromosome and causing that clock that I was talking about earlier, that biological clock.

[1723] to accelerate.

[1724] Is there something you can do to mitigate that?

[1725] If you know you have to get an x -ray, should you do something right afterwards?

[1726] Potentially.

[1727] Potentially, you could take NMN, which we've shown in mice, protect them against the effects of radiation.

[1728] And that's one of things we've talked to NASA about for getting to Mars and back safely.

[1729] So when I'm on a flight, I take some MN in the expectation that it's going to boost my body's ability to prevent those changes to the clock.

[1730] Now, is there a commercially available NMN that you would suggest if someone wants to purchase it somewhere?

[1731] Well, so I don't divulge company names, and there's two reasons for that.

[1732] One is I've tested them, so I actually literally don't know.

[1733] But the other is that, you know, I want to stay above the fray and not get involved.

[1734] But there are, if people want to go Google and go look online, they can find commercially available NMN.

[1735] right um so yeah again i've got a number of pages in in the book on that so it's it's all laid out but in summary this book right here ladies and gentlemen look at that lifespan why we age and why we don't have to thanks joe that's my npr voice yeah you can donate if you enjoy programming like this you're putting me to sleep i know that's what they do man yeah something happened with people they thought to be intelligent you have to talk like you're you're ready to to put people to sleep.

[1736] It's time to get sleepy.

[1737] Anyway, so the NEMN, so there are people who's selling it on the internet.

[1738] Just to get the facts straight, I don't sell anything.

[1739] My name's all over the internet.

[1740] If you see my name with a company, it's BS.

[1741] Uh -huh.

[1742] Beautiful.

[1743] That's good.

[1744] Anyway, so the NMN, there are companies that sell.

[1745] It's more expensive than another molecule that's related called NR or nicotinamide ribicide, which is also what the body can use to boost NAD level.

[1746] and that's a little bit cheaper.

[1747] And they've both been shown in animals to boost the Sertuans and help those animals be healthier in old age and reverse some aspects of aging like endurance, loss of endurance, that kind of thing.

[1748] Protect the eye, protect the hearing as well.

[1749] So we don't know if it works in humans.

[1750] Let's be honest.

[1751] We don't know if these things work.

[1752] But let's also be honest.

[1753] We know what's going to happen if we don't do anything.

[1754] And that's not pretty either.

[1755] do you have any high hopes for things like CRISPR things where there's going to be genetic alterations and they are starting to do some experience you have a big smile on your face right now so i'll let you talk go ahead tell me what's up uh well uh so i'm a geneticist and i'm just down the hall from george church who's in my department at harvard and i'm a big believer in crisper uh in the sense that it will revolutionize medicine now right now you explain it to people who don't know what it means.

[1756] So CRISPR is an acronym for basically a system that is from bacteria that they use to kill and destroy the DNA of invading organisms like a virus.

[1757] But we can now use that system to cut and change our own genomes.

[1758] It's basically a DNA cutting enzyme that doesn't randomly, you can give it a barcode in the form of what's called RNA molecule that tells where that enzyme will cut in the genome.

[1759] Let's say you, Joe, Rogan have a terrible gene that's causing heart disease.

[1760] We take this CRISPR system.

[1761] We say, here's where you need to go to cut.

[1762] We can tell the enzyme to go and cut it.

[1763] Put it into your cells.

[1764] It'll go cut it and destroy that enzyme and delete it.

[1765] And you can also use it to cut the genome and insert new pieces.

[1766] So you can both subtract and add DNA at will now, not just randomly, but what's important is you can tell it where to go.

[1767] And that's the big breakthrough.

[1768] And they're doing some experiments on human beings.

[1769] I know there was something that they were doing, I believe, somewhere in Asia, if I remember correctly, I believe it was China, where they had done some manipulation to people to help prevent AIDS and in the process of doing so, they may have boosted intelligence or the potential for intelligence, which was so convoluted that my puny little brain can not understand the study.

[1770] I had to go over the same paragraph like four or five times just try to figure out what the fuck they were saying.

[1771] Am I making any sense?

[1772] Yeah, you are.

[1773] You are.

[1774] And that was a study that I don't believe it's been published, but it's been reported that he is his name, his last name is he took embryos and engineered them to delete CCR5 gene, which is required for HIV to infect cells.

[1775] Now, that was, most of us scientists think that that was reckless for the fact that, first of all, HIV isn't a huge risk in China.

[1776] It's one in a thousand chance of getting HIV.

[1777] There are plenty of other things that you could do that could be more helpful.

[1778] Let's say, why not mutate what's called PSK9 to prevent heart disease, which would probably have 50, percent to kill the boys, a boy.

[1779] So anyway, it wasn't the most risk benefit ratio modification.

[1780] That's one thing.

[1781] But the other is we don't know what happens when you cut genes in embryos.

[1782] Does it have changes to the DNA clock?

[1783] Did it accelerate their aging?

[1784] Did it mess with other genes?

[1785] Did it cut in other places and screw up those genes?

[1786] We don't know that yet.

[1787] And so that's why the scientific community had a negative reaction to it.

[1788] But what's interesting is that that the scientific community and the press has pretty much gone quiet on this.

[1789] Imagine if this happened during the Bush era, we'd have protesters all over the place.

[1790] It'd be outlawed, and that hasn't happened.

[1791] And I think it's because we live in a world with a 24 -hour news cycle.

[1792] But isn't that also because it's being, if it was during the bush world, I mean, the protests would really take place if it was done here.

[1793] The thing about things that are done in China or overseas, like, huh, it's like it's so far away, like, well, let's keep an eye on them.

[1794] Yeah, that's true.

[1795] So there is the fear that some country is going to engineer an army of clones.

[1796] I mean, we have the technology to do that right now.

[1797] Yeah?

[1798] We believe we understand how to slow aging.

[1799] There are genes that predispose you to long life.

[1800] We could make offspring a family that would potentially live a lot longer.

[1801] But is this something that can only be manipulated in embryos or in fetuses?

[1802] No. Now we can do it in adults.

[1803] Actually, there are drugs that are in development to actually correct genetic diseases, such as vision loss.

[1804] Really?

[1805] Dude, my eyes are gone.

[1806] I can barely read, like, print on a laptop.

[1807] I need glasses to read my laptop.

[1808] All right.

[1809] So we just put up a study online on a site called Bio Archive.

[1810] Anyone can go there and see it.

[1811] Just Google my name in Bio Archive.

[1812] B -I -O -R -X -V.

[1813] Reason that's interesting is that what we're showing, is in mice at least, we can reverse the age of the retina and restore the vision of old mice.

[1814] What do I have to do?

[1815] Well, I think you have to blow me a few more times.

[1816] Hey, come on, man. You're going to lose your job.

[1817] You've got to let me crack those kind of jokes.

[1818] Sorry.

[1819] Harvard, I was joking.

[1820] I started it, folks.

[1821] It's not his fault.

[1822] So what would someone, I mean, is this going to be available to the general public any time in our lifetime?

[1823] I'm trying my best.

[1824] We're hoping to do clinical trials starting in two years from now.

[1825] Really?

[1826] And what would you do in those clinical trials?

[1827] So we'd reprogram the eye to be young again.

[1828] So we now know that there's a set of genes called reprogramming factors, also known as Yamanaka factors that are from named after this Japanese fellow who won the Nobel Prize in 2012.

[1829] These factors are used all over the world, even probably in high schools, to reprogram skin cells, other cells to be what we call pluripotent stem cells.

[1830] These are cells that can be used to make new organs or new blood cells.

[1831] But what people hadn't tried until recently was, can you do this in a living animal, or are you just going to mess it up?

[1832] And what we found out is that if you do it the wrong way, you mess up the animal, and it'll die.

[1833] But what we've shown for the first time in this paper is you can do it in a safe way.

[1834] And not only that, reverse the clock, make the cells young, and restore how they work and get back vision.

[1835] And what's the methodology?

[1836] Right, good question.

[1837] So the current method is using a virus that's on the market.

[1838] These are called AAVs, adeno -associated viruses.

[1839] You put them in the eye.

[1840] They're already patients getting this on the market.

[1841] Really?

[1842] Yeah.

[1843] Spark therapeutics is an example of a company that is curing genetic diseases in the eye with viruses.

[1844] Or in a new world.

[1845] Most people don't know about it.

[1846] Wow.

[1847] So what is the company again?

[1848] Jamie, look up the Spark genetic injury or Jamie's already got it.

[1849] Look at that.

[1850] Bam, motherfucker.

[1851] Jamie Vernon in the house.

[1852] So these folks are already doing this to people.

[1853] So is this for people that are sort of desperate and they'll try something experimental?

[1854] Right.

[1855] Well, they're desperate in the sense that there's no other choice.

[1856] No other cure.

[1857] I mean, we're now curing genetic diseases.

[1858] Someone was just treated and cured of sickle cell anemia.

[1859] That's phenomenal.

[1860] And that, you know, I learned that that comes from malaria, right?

[1861] That was the idea that people were, the resistance to malaria.

[1862] It was that trait from people that evolved in the area where they would get malaria was also what led to people getting sick or sell, correct?

[1863] Correct.

[1864] So I learned that from Tiffany Hatch, by the way.

[1865] Amazing.

[1866] Tiffany, shout out to Tiffany.

[1867] That Lux Turner stuff, is this something that someone like me could take right now?

[1868] No, not easily.

[1869] Your doctor would need to prescribe.

[1870] it.

[1871] And so if he did prescribe it, I could literally get vision back?

[1872] Well, this is not the same technology that I'm talking about it from my life.

[1873] This is inherited retinal diseases, our commitment to our IRDs.

[1874] This is gene replacement, not reprogramming the body to be young, but it's the same virus that we'd use to correct aging.

[1875] So they're using this for certain retinal diseases where they're correcting it.

[1876] Now, how is this bacteria fixing your vision?

[1877] Well, the viruses are just a way to get the genes into the cells.

[1878] That's all.

[1879] And these are benign viruses.

[1880] They don't hurt you.

[1881] But they're a carrier.

[1882] And maybe eventually we'll have other ways to do this.

[1883] But right now the virus is the best way.

[1884] And in the mice, to restore the vision, we have this three -gene combination of these Yamanaka reprogramming genes.

[1885] We put them into the eye, and then we turn them on with a drug.

[1886] In fact, the same drug that I took when I was in Africa, called doxycycline, is the same drug we can feed to the mice.

[1887] turns on the reprogramming genes for a few weeks restores their vision back to a young mouse and then we just take away the doxycycline and antibiotic and the mice have their vision back.

[1888] And how long does it take for it starts deteriorating again?

[1889] We don't know yet, but we think that it's permanent.

[1890] Because the age of the cells has gone back.

[1891] Those are young eyes again.

[1892] So you might have a whole full cycle from like 20 or 10 to 40 years old again.

[1893] That's the future that you'll get a delivery of this virus, you'll take the antibiotic for a few weeks, be fully rejuvenated, and the doctor says come back in a couple of decades, we'll fix you again, or we'll give you some antibiotic in a couple of decades.

[1894] But then it gets really weird if you have a, if you engineer your children to have this system, if that ever happens, let's imagine it could, we could do this right now with technology, and you have people engineered to be able to be reversed in their age, or let's say they have an accident and their optic nerve gets damaged or they lose the hearing from a bomb or something that spinal injury give them a dose an IV of antibiotics and they become just like an embryo they can rejuvenate they can regrow their optic nerve regrow their spine fixed back back like new the the vision thing do you think that we're going to see that in our lifetimes I mean is this something that you're going to see that's going to be available to the general public well so so I've got I'm an entrepreneur as we discussed before and so one of the companies that I've started is exactly that, raised money, to be able to make this virus.

[1895] We're making it now.

[1896] It takes a few million bucks.

[1897] And we'll, hopefully, with the FDA's approval, inject it into people's eyes.

[1898] Now, first, it won't just be guys like you.

[1899] First of all, we have to go into an area where it's FDA approval, which is a disease like glaucoma, which is pressure in the eye or macular degeneration.

[1900] That's our first goal.

[1901] But then if it's safe, why not do old eyes?

[1902] Wow.

[1903] That's incredible.

[1904] Now, what about people with injuries?

[1905] Yeah.

[1906] Well, yeah, you could theoretically put it into the spinal cord or give an IV.

[1907] But people with eye injuries.

[1908] Oh, for sure.

[1909] So one of the things we also did in this paper that we put online is we pinched the optic nerve.

[1910] And what normally happens is it just degrades.

[1911] I mean, nerves don't grow back, right, unless you're a baby mouse or a baby human.

[1912] But we made those cells so young that the optic nerve grew back to the brain.

[1913] Wow.

[1914] First time that's been able to have it.

[1915] I know a guy from fighting.

[1916] He's got a detached retina, detached so bad that his vision and his right eyes, extremely poor.

[1917] Shout out to Michael Bisping.

[1918] Do you think that that's something that inside of his lifetime, they could see something, the use of this technology, that could regenerate his eye?

[1919] Well, I get a lot of emails, so I'm not really trying to overpromise anything.

[1920] What I think is possible is that initially it will be used for a disease, a chronic disease.

[1921] then it'll be used for injuries like that, but fresh injuries.

[1922] I think it's probably likely to work better if it's fresh.

[1923] I don't know where this technology is going.

[1924] I can imagine a lot.

[1925] We can all imagine that you could get vision back and people walking again.

[1926] But that's where this technology is going.

[1927] So I described the discovery in the book as actually what happened while I was writing the book is we were making these discoveries and they were remarkable.

[1928] And so I wrote them down in the book as we went along.

[1929] So people can see how it feels to be a scientist to make.

[1930] these discoveries.

[1931] But it's only been a year or less that we've known about this.

[1932] So imagine 50 years from now what we can do, even 10.

[1933] It's going to be a remarkable future.

[1934] It's very exciting.

[1935] Now, what kind of a timeline are you anticipating for bringing this to, you know, people with injuries?

[1936] Well, injuries, already we have a study plan for spinal injury in mice and that we'll probably know the results in less than a year.

[1937] And then we could, you know, as fast as the FDA allows us go into a clinical trial.

[1938] Now, is the same scenario applicable for people with spinal injuries as vision, like people that have a more recent spinal injury would be more likely candidates than people that have had older spinal injuries?

[1939] I think so.

[1940] That would just be my guess that it's easier to fix a recently damaged system, anything in the body that's fresh.

[1941] But I wouldn't rule out anything.

[1942] When we first discovered this, the experiment was to have a fresh injury, the pinching of the optic nerve.

[1943] But then I said to my student, why don't you just try old mice?

[1944] And he said, come on, old mice, are you kidding me?

[1945] How's that going to work?

[1946] Just try it.

[1947] Just try it.

[1948] So he did it.

[1949] And in collaboration with another lab at Harvard, so they're the experts.

[1950] And so Bruce Cassandra is his name.

[1951] So Bruce called me, Professor at Harvard.

[1952] It's 10 .30 at night.

[1953] It just got off a plane.

[1954] He said, David, you won't believe it.

[1955] I didn't believe it.

[1956] I just looked at the data.

[1957] It freaking worked.

[1958] Old mice are seeing again.

[1959] He said, I want to go down to the FDA and tell them about it.

[1960] Because right now, eye diseases typically, all you can do is slow them down, and here's actually a reversal of lost function.

[1961] Now, does this apply to injuries as well, do you believe, old injuries, or just old macular degeneration?

[1962] We haven't tried old injuries.

[1963] Now, we've done glaucoma, which is an old injury.

[1964] So theoretically, what we could do is at least with the existing nerves, if they're still attached, we should be able to rejuvenate those and make them work better.

[1965] Because he has some vision in his eye.

[1966] So, yeah, so that's possible.

[1967] That makes more sense.

[1968] But very little.

[1969] Very limited in one eye.

[1970] Yeah.

[1971] Well, we'll have to see.

[1972] Interesting.

[1973] Because you didn't think it was going to work on the old mice.

[1974] I did.

[1975] But no one else did.

[1976] Wow.

[1977] Crazy.

[1978] Well, we're literally reversing, not just the effects of aging, but aging itself.

[1979] So if I gave you those retinas, very little retinas, here you go, Joe.

[1980] And you were a scientist, you could look at that retina and analyze it molecularly.

[1981] measure its clock and you'd say those are young eyes and you wouldn't know the difference now do you feel like this kind of technology is also going to be applied to people's skin because you know one of the things that for women it's devastating when they develop wrinkles you know they fucking hate it men get a few wrinkles they kind of look distinguished you know but man when women get wrinkles they freak the fuck out they don't like it yeah we're going to try it on on aging on the skin though you know when i talk about making people walk again potentially.

[1982] It's probably a higher priority.

[1983] Oh, for sure.

[1984] But I think it's feasible.

[1985] So there's a lab at the Salk Institute, Juan Carlos Belmonte, who may win the Nobel Prize for his work on this.

[1986] In 2016 and a couple of years since, he's been showing that it doesn't just rejuvenate old mice.

[1987] It actually is also rejuvenating the skin.

[1988] If he puts it on a wound that's in an old mouse, that mouse will heal better.

[1989] Now, that doesn't prove wrinkles, but it does prove the skin can be uh rejuvenated as well so there could be possibly some sort of a treatment to skin maybe a re -injuring like of you there's this thing that they do i think it's called a vampire facial have you ever heard of that they take platelet rich plasma and then they micro needle your entire face and then they somehow another apply this platelet rich plasma to the areas that have been microneedled and it has some sort of an effect in increasing collagen and elasticity of the skin and tightening of the skin.

[1990] Have you heard of this?

[1991] I've heard it for hair loss.

[1992] I didn't realize people get it all over their face.

[1993] For hair loss as well?

[1994] They're doing that.

[1995] It sounds painful.

[1996] So to me it makes sense that it might work.

[1997] The PRP, as it's called, is full of factors that we know some of these are rejuvenating in mice.

[1998] You know, this system where you can hook up an old mouse and a young mouse circulation?

[1999] Yes.

[2000] And you get rejuvenation.

[2001] There are factors that many of which we haven't discovered or identified that exist, that you can rejuvenate.

[2002] And I would bet that they're working most likely through this reversal of the clock.

[2003] And so one of the things we're doing in my lab is taking what are called exosomes, which exist in these preparations, and seeing if they reverse the clock.

[2004] I've had exosomes shot into injuries for stem cell procedures.

[2005] Yes.

[2006] Yes, it did work.

[2007] Makes sense.

[2008] Yeah, I had a full -length rotator cuff tear that's completely gone.

[2009] Yeah, so maybe what's going on is you've reprogrammed your body there.

[2010] Yes.

[2011] Well, there's, it's a weird thing, the exosomes and stem cells, and there's a new product called Wharton's Jelly that's also very effective and potent because there's not a lot of papers on these things.

[2012] It's all, you know, the research on it is some of it's a little shaky, but the efficacy, at least anecdotal efficacy, is pretty specific.

[2013] substantial.

[2014] And I'm one of those pieces of anecdotal evidence.

[2015] I've had a bunch of shots.

[2016] I just, whenever I get injured, I'm like, shoot it up.

[2017] Yeah.

[2018] Well, your listeners may not know about exosomes.

[2019] So exosomes are little compartments that are pinched off from cells and put into the body and communicate between cells across.

[2020] So your liver can communicate with your brain through exosomes.

[2021] And within these little cargoes, there are things that we're just discovering, little proteins, RNA, and they're full of goodies.

[2022] And drug companies are being built on these exosomes.

[2023] Yes.

[2024] I'm glad you brought up the study of the old mice and the young mice, where they put the blood in the old mice, and then the old mice started behaving like young mice, and the blood of the old mice and the young mice, and the young mice started behaving like they were tired, because there's a company in Northern California that's supposedly doing this with humans, where they're injecting people with the blood of old people, or young people, rather, some sort of transverse.

[2025] fusion not anymore not anymore they out of business well my understanding is the fda sent my letter uh -huh said stop it that's it just a letter it's all takes oh yeah you don't want to go to the next down the street and change your name oh i got another letter move down the street change my name uh i think that's risky is it check to see if that company's under i do not remember the name of it but i know i remember they were erroneously linked to peter teal and then peter denied that he's ever used that you know the billionaire founder of PayPal, who I've met, who's a wonderful man. They erroneously, someone, just some story linked, that said that he's getting it.

[2026] He's like, actually, shut the fuck up.

[2027] No, I'm not.

[2028] Don't say that.

[2029] I've never done it.

[2030] Not doing it.

[2031] So it was one of those things where there was a lot of legend to it because of these mice studies.

[2032] These mice studies get people super excited about the idea that all you have to do is get young people's blood.

[2033] So you get a bunch of young people, whether it's healthy, disease -free.

[2034] drug -free donating their plasma, donating their blood for X amount of dollars, a quart.

[2035] Right, you have a blood boy, hook yourself up.

[2036] Yeah, blood boy.

[2037] Hey, man, when I was young, I needed some cash.

[2038] I was healthy.

[2039] Come on.

[2040] You regenerate that shit, you know?

[2041] Take a quart of blood.

[2042] I get it back in a couple hours.

[2043] I think it might work.

[2044] It's just that we don't know the consequences, and the FDA's job is to protect us.

[2045] Yeah, just like they're protecting us from raw milk, a bunch of pussies.

[2046] Just recently shut down about a month ago.

[2047] I missed the boat.

[2048] could have been in there, man. But if you did that, that's something that you'd have to do on a routine basis, right?

[2049] It's not like something you could do one shot.

[2050] It'd probably give you a little boost for a short amount of time.

[2051] Yeah.

[2052] Well, that's what's different about this reprogramming.

[2053] You do it once.

[2054] You come back years later.

[2055] Yeah, the eyeball thing is very enticing to me because it's so weird watching my eyes deteriorate.

[2056] Like, slowly but surely I'm watching it happen.

[2057] It's really...

[2058] It sucks.

[2059] And it's a short sign you get an older.

[2060] Yeah, age -related macular degeneration just seems.

[2061] pretty standard except my friend cam haines that motherfucker he's 52 years old he could see like he's got like 2018 vision at 52 it's crazy you can see anything i dropped my phone on the ground he's like oh you got a crack he saw it from like where where's the crack i go i'm trying to look at it in the light it's like right there and i put reading glasses on i'm like son of a bitch i'm like how the fuck did you see that he saw it from like where you are like looking at the phone i'm like that is crazy.

[2062] Well, so let's keep in touch.

[2063] We will.

[2064] And if we get this on the market, then uh -huh.

[2065] Yeah.

[2066] Yes.

[2067] It turns out he has started up again as pretty recently, but it's not being sold as young blood for plasma.

[2068] It's just plasma.

[2069] It's not young.

[2070] Just give it a shot, bro.

[2071] Just, uh, no promises.

[2072] What do you think?

[2073] You want to go in there with me?

[2074] Right after we do the, uh, cryotherapy treatment, go get some blood, some young blood.

[2075] Doctors behind failed anti -aging blood clinic tries again.

[2076] We tried to ask him some questions, but he was very evasive.

[2077] Good for you, sir.

[2078] Duck and move.

[2079] Do the old Muhammad Ali Ropa Dope.

[2080] Be like Pernell Whitaker, sir.

[2081] Yeah, I hope he stays evasive.

[2082] I mean, it's also like maybe it's nonsense.

[2083] Maybe it's not.

[2084] Would you like to do studies on people that are doing that and find out?

[2085] I mean, well, what they should do is measure the clock now that we can do that.

[2086] Right.

[2087] Yes, that would be interesting.

[2088] But based on what we know about how it works with mice, you think it's likely that there is some effect.

[2089] It's possible.

[2090] It's possible.

[2091] I like how you're very cautious.

[2092] You're a real professor.

[2093] I like that.

[2094] I try.

[2095] You're the real deal.

[2096] I'd like to keep my job.

[2097] You should.

[2098] Stop making those blowjob jokes.

[2099] Funny that that is actually controversial.

[2100] Two friends can't just joke.

[2101] Is there anything else that you think is promising that is on the horizon or that's being discussed or it's theoretical at this point?

[2102] Yeah, there's something that is really interesting.

[2103] And that's called senolytics.

[2104] Senolytics.

[2105] Yeah.

[2106] So senolidics are drugs that kill off senescent cells.

[2107] So what are senescent cells?

[2108] These are often called zombie cells.

[2109] And what I think is...

[2110] war z yes a lot of zombies this uh podcast so senescent cells we've known for decades exist in the body but what was not clear was whether they cause aging now it's pretty clear from animal studies at least is that we get lots of these accumulating and that they do cause aging and one of the best experiments that was done from mayo clinic was to genetically delete the senescent cells that accumulated in an old mouse and it became young again or at least it delayed its aging by a fair bit Now, senescent cells are pretty rare, there's not a lot of them, but they cause havoc because they don't just sit there in the body, but they send out these inflammatory markers and they cause cancer, we think.

[2111] So you want to get rid of these.

[2112] Just I want to mention that in the biological clock when I was saying that the clock is part of the aging process, what we think is that as we get older, and it's detailed a lot more in my book, so if people read it, they'll understand a lot more what I'm saying.

[2113] But this clock is messing up the cell's ability to be what it used to be.

[2114] What do I mean by that?

[2115] Let's take your eye.

[2116] In your retina, your nerves are getting older, but your nerves, we think, are losing the ability to read the nerve genes.

[2117] So they're forgetting that they're nerves.

[2118] So now they're starting to behave actually more like a skin cell.

[2119] And having a skin cell in your eyes not going to really work very well.

[2120] So that we call that epigenetic noise, epigenetic aging.

[2121] Reprogramming resets that.

[2122] So why is that interesting?

[2123] We think that the ultimate problem for the cell, when it loses its total identity or gets a long way towards that, is it shuts itself down because it says, fuck, I don't even know what I am anymore.

[2124] I'm not a nerve cell.

[2125] I'm not a skin cell.

[2126] I'm not a liver cell.

[2127] Cines.

[2128] Senece means stop dividing.

[2129] Just sit there and tell the body, come kill me. So now they're putting out these panic factors.

[2130] There's a problem.

[2131] You get inflammation.

[2132] The problem is that as we get older, the body's not very good at clearing out these cells.

[2133] They sit there and they wreak havoc.

[2134] You get inflammation.

[2135] We think you get aging.

[2136] So getting back to senolytics, these drugs are designed to be a pill or an injection into your joint to kill off these zombie cells, these senescent cells.

[2137] And theoretically, rejuvenate the tissue and reverse that aspect of aging.

[2138] And that's another treatment like reprogramming that could be a one -shot delivery and take you back a decade.

[2139] Wow.

[2140] And how far away are we from seeing those?

[2141] Much closer, actually.

[2142] There's a few companies.

[2143] There's one called Unity.

[2144] There's one that I'm involved with in full disclosure called Centaetic Therapeutics in Europe.

[2145] And at least Unity is in clinical trials right now for osteoarthritis.

[2146] Really?

[2147] Now what about the company in Europe?

[2148] Pre -clinical, still a mouse.

[2149] Wow.

[2150] So we're looking at like a decade from the general public?

[2151] Well, for Unity, they hope not.

[2152] Usually when you're in a phase two study, which they're in, it's a few years away if it works.

[2153] Oh, wow.

[2154] Amazing stuff.

[2155] It's such a cool time to see all this medical innovation and technological and scientific innovation.

[2156] Well, my head's spinning.

[2157] This CRISPR and then the reprogramming, which is new stuff.

[2158] This is stuff that we dreamed of for thousands of years.

[2159] And, you know, I don't think it's a dead end, and it may not be.

[2160] as, you know, we're not going to go back to being 20 anytime soon.

[2161] That said, I think we've had a major breakthrough.

[2162] The equivalent I like to use is we figured out how to fly.

[2163] We're the right brothers, the right sisters.

[2164] We've got to include all sexes now.

[2165] My daughter will tell me. Right non -binary people.

[2166] Yeah.

[2167] So my daughter changed her name, by the way.

[2168] To what?

[2169] To Alexander.

[2170] She was Madeline.

[2171] She didn't think that was appropriate.

[2172] Why?

[2173] She's a tough chick.

[2174] She's a they, and so I'm not allowed to call her a she, I don't think.

[2175] She doesn't want to be identified as one or the other.

[2176] Interesting.

[2177] Is she 16?

[2178] Yeah, she changed it at 11.

[2179] Whoa.

[2180] She's a tough girl.

[2181] You know, in my family, we tend to be rebels, and unfortunately, it passed along.

[2182] I'm getting everything back.

[2183] Fortunately or unfortunately.

[2184] Well, I guess I'll be proud of her, but raising her in the last few years have been pretty annoying at home.

[2185] Can't say anything without the PR police.

[2186] That's hilarious.

[2187] Is it?

[2188] PC, please, or PR?

[2189] Did I say PR?

[2190] I made PC.

[2191] Yeah, that's interesting.

[2192] What was I saying about my daughter?

[2193] Oh, about the name change.

[2194] Yes.

[2195] Why was I talking about a name change?

[2196] I don't know.

[2197] You tell me. Jamie, do you remember?

[2198] Man, we got a million people screaming at us.

[2199] Yeah, well, you were talking about so many exciting things on the horizon.

[2200] True, yeah.

[2201] And so that it's just head spinning.

[2202] And so much is happening in our lifetime that I thought was just imaginary.

[2203] or for the future.

[2204] Now the question is, are we going to reap all the benefits of this, or we're going to be the last generation to lead a normal human lifespan?

[2205] And I don't think we are.

[2206] I think that we already have things we can do in our daily lives, just in lifestyle and in molecules you can take, that give us a very good chance of living beyond what's naturally possible.

[2207] This is amazing, man. It's so exciting.

[2208] And the last time you hear was about a year ago, somewhere around that range.

[2209] Yeah.

[2210] Yeah.

[2211] I mean, and think about how many new things you have to discuss now, versus then it's really interesting man and i'm so happy there's people like you that are out there doing this it's just uh it's so it's just so exciting and it's so it makes me very happy to know you're out there thanks sir so thank you and your book um people can find out all this stuff in detail much more detail than get in a two and a half hour conversation lifespan why we age and why we don't have to david a sinclair ph d thank you brother always good time we'll do it again next year.

[2212] Deal.

[2213] Yes.

[2214] Bye, everybody.