#145 – Matthew Johnson: Psychedelics

[0] The following is a conversation with Matthew Johnson, a professor of psychiatry and behavioral science at John Hopkins, and is one of the top scientists in the world conducting seminal research on psychedelics.

[1] This was one of the most eye -opening and fascinating conversations I've ever had on this podcast.

[2] I'm sure I'll talk with Matt many more times.

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[8] As a side note, let me say that psychedelics is an area of study that is fascinating to me, and that it gives hints that much of the magic of our experience arises from just a few chemical interactions in the brain, and that the nature of that experience can be expanded through the tools of biology, chemistry, physics, neuroscience, and artificial intelligence.

[9] The fact that a world -class scientist and researcher like Matt can apply rigor to our study of this mysterious and fascinating topic is exciting to me beyond words.

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[58] And now, here's my conversation with Matthew Johnson.

[59] Can you give an introduction to psychedelics, like a World Wind Overview?

[60] maybe what are psychedelics and what are the kinds of psychedelics out there and in whatever way you find meaningful to categorize.

[61] Yeah.

[62] You can categorize them by their chemical structure, so phenethylamines, tryptomines, ergolines, that is less of a meaningful way to classify them.

[63] I think that their pharmacological activity, their receptor activities, the best way.

[64] Well, let me, let me start even broader than that, because there I'm talking about the classic psychedelics.

[65] So, broadly speaking, when we say psychedelic, that refers to, for most people, a broad number of compounds that work in different pharmacological ways.

[66] So it includes the so -called classic psychedelics.

[67] That includes psilocybin and psilocin, which are in mushrooms, LSD, dimethyl -tryptamine or DMT, it's in ayahuasca, people can smoke it to, mescaline, which is in peyote and San Pedro, cactus.

[68] And those all work by hitting a certain subtype of serotonin receptor, the serotonin 2A receptor.

[69] They act as agonists at that receptor.

[70] other compounds like PCP, ketamine, MDMA, ibogaine, they all are more broadly speaking, called psychedelics, but they work by very different ways pharmacologically, and they have some different effects, including subjective effects, even though there's enough of an overlap in the subjective effects that, you know, people, informally refer to them as psychedelic.

[71] And I think what that overlap is, you know, compared to say, you know, caffeine and cocaine and, you know, Ambien, et cetera, other psychoactive drugs, is that they have strong effects in altering one's sense of reality and including the sense of self.

[72] And I should throw in there that cannabis, more historically like in the 70s, has been called a minor psychedelic.

[73] And I think with that latter definition, it does fit that.

[74] definition particularly if one doesn't have a tolerance so you mentioned serotonin so most of the effect comes from something around like the chemistry around neurotransmitters and so on so it's chemical interactions in in the brain or is there other kinds of interactions that have this kind of perception and self -awareness altering effects well as far as we know all of the the psychedelics of all the different classes.

[75] We've talked about their major activity is caused by receptor level events.

[76] So either acting at the post -receptor side of the synapse, so in other words, neurotransmission operates by, you know, one neuron releasing neurotransmitter into a synapse, a gap between the two neurons, and then the other neuron receives.

[77] It has receptors that receives, and then there can be an activation caused by that.

[78] So it's like a pitcher and a catcher.

[79] So all of the major psychedelics work by either acting as a pitcher, mimicking a pitcher or a catcher.

[80] So for example, the classic psychedelics, they fit into the same catchers mitt on the post -receptor, post -synaptic receptor side as serotonin itself.

[81] But they do a slightly different thing to the cell, to the neuron, than salientic.

[82] serotonin does.

[83] There's a different signaling pathway after that initial activation.

[84] Something like MDMA works at the presynaptic side, the pitcher side, and basically it floods the synapse or the gap between the cells with a bunch of serotonin, the natural neurotransmitter.

[85] So it's like the pitcher in a baseball game all of a sudden just starts throwing balls like every second.

[86] Everything we're talking about is it often more natural, meaning found in the natural world?

[87] You mentioned cacti, cactus, or is it chemically manufactured, like artificially in the lab?

[88] So the classic psychedelics, there's...

[89] What are the classics?

[90] So using terminology, that's not chemical terminology, not like the terminology you see in titles of papers, academic papers, but more sort of common parlance.

[91] Right.

[92] it would be good to kind of define their, you know, their effects, like how they're different.

[93] And so it includes LSD, psilocybin, which is in mushrooms, mescaline, DMT.

[94] Which one is mescalin is in the different cacti.

[95] So the one most people will know is peyote, but it also shows up in San Pedro or Peruvian torch.

[96] And all of these classic psychedelics, they have at the right dose, you know, and typically, they have very strong effects.

[97] on one sense of reality and one sense of self.

[98] Some of the things that makes them different than other, more broadly speaking, psychedelics like MDMA and others, is that they're, at least the major examples, there are some exotic ones that differ, but the ones I've talked about are extremely safe at the physiological level.

[99] Like there's LSD and psilocybin, there's no known lethal overdose, unless you have like really severe, you know, heart disease, you know, because it modestly raises your blood pressure.

[100] So same person might be hurt shoveling snow or going up the stairs, you know, that could, you know, have a cardiac event because they've taken one of these drugs.

[101] But for most people, you know, someone could take a thousand times what the effective dose is and it's not going to cause any organ damage, affect the brain stem, make them stop breathing.

[102] So in that sense, you know, it's, they're freakishly safe at the physiolite.

[103] I would never call any compound safe because there's always a risk.

[104] They're freakishly safe at the physiological level.

[105] I mean, you can hardly find anything over the counter like that.

[106] I mean, aspirin's not like that.

[107] Caffeine is not like that.

[108] Most drugs, you take 5, 10, 20, maybe it takes 100.

[109] But you get to some times the effect of dose and it's going to kill you or call some serious damage.

[110] And so that's something that's a remark about most of these classic psychedelics.

[111] That's incredible, by the way.

[112] that you can go on a hell of a journey in the mind, like probably transformative, potentially in a deeply transformative way, and yet there's no dose that in most people would have a lethal effect.

[113] That's kind of fascinating.

[114] There's this duality between the mind and the body.

[115] It's like, it's the, okay, sorry if I bring him up way too much, but David Goggins, it's like, you know, the kind of things, you go on a long run, like the hell you might go through in your mind.

[116] Your mind can take a lot and you can go through a lot with the mind and the body will just be its own thing.

[117] You can go through hell, but after a good night's sleep, be back to normal and the body is always there.

[118] So bringing it back to Goggins, it's like you can do that without even destroying your knee or whatever.

[119] Or coming close and riding that line.

[120] That's true.

[121] So the unfortunate thing about the running, which he uses running to test the mind.

[122] So the aspect that of running that is negative, in order to test the mind, you really have to push the body, like take the body through a journey.

[123] I wish there was another way of doing that in the physical exercise space.

[124] I think there are exercises that are easier in the body than others, but running sure is a hell of an effective way to do it.

[125] And one of the ways that where it differs is that you're unlike exercise, you're essentially, you know, most exercise are quite to really get to those intense levels.

[126] you really need to be persistent about it.

[127] I mean, it'll be intensive.

[128] You're really out of shape just, you know, jogging for five minutes.

[129] But to really get to those intense levels, you need to, you know, have the dedication.

[130] And so some of the other ways of altering subjective effects or states of consciousness take that type of dedication.

[131] Psychedelics, though, I mean, someone takes the right dose.

[132] They're strapped into the roller coaster.

[133] And something interesting is going to happen.

[134] And I really like what you said about that distinction between the mind or the contrast between the mind effects and the bodily, the body effects because I think of this.

[135] I do research with all the drugs, you know, caffeine, alcohol, methamphetamine, cocaine, alcohol, legal, illegal.

[136] most of these drugs, thinking about, say, cocaine and methamphetamine, you can't give to a regular user, you can't safely give a dose where the regular cocaine user is going to say, oh, man, that's like, that's the strongest coke I've ever had, you know, because, you know, you get it past the ethics committee and you need approval.

[137] And I wouldn't want to give someone something that's dangerous.

[138] So to go to those levels, where they would say that, you would have to give something that's physiologically riskier.

[139] Yeah.

[140] You know, psilocybin or LSD, you can give a dose at the physiological level that is like, very good chance it's going to be the most intense psychological experience of that person's life.

[141] Yeah, that's amazing.

[142] And have zero chance for most people if you screen them of killing them.

[143] The big risk is behavioral toxicity, which is a fancy way of saying doing something stupid.

[144] I mean, you're really intoxicated.

[145] Like if you wander into traffic or you fall from a height, just like plenty of people do on high doses of alcohol.

[146] And the other kind of unique thing about classic psychedelics is that they're not addictive, which is pretty much unheard of when it comes to so -called drugs of abuse or drugs that people, at least at some frequency, choose to take.

[147] you know most of what we think of as drugs um you know even caffeine alcohol cocaine cannabis um most of these you can get into alcohol you can get into a daily use pattern and that's just extreme so unheard of with psychedelics most people have taken these things on a daily basis it's more like they're building up the courage to do it and then they build up a tolerance or yeah they're in college and they do it on a dare can you take acid seven days in a row and that type of thing rather than a self -control issue where you have and say oh god i got to stop taking this i got to stop drinking every night i got to cut down on the coke whatever so that's the classic psychedelics uh what are the uh what's a good term modern psychedelics or more maybe psychedelics that are created in the lab what else is there right so mdMA is the big one and i should say that that with the classic psychedelics that lSD is sort of you can call it a semi -synthetic because there's there's there's natural you know from from both ergot and in certain seeds um morning glory seeds as one example there's a very close there are some very close uh chemical relatives of lSD so lSD is close to what occurs in nature but not quite it's but then when we get into the the other um non -classic psychedelics probably the most prominent one is mdMA people call it ecstasy people call it molly um And it is, it differs from classic psychedelics in a number of ways.

[148] It can be addictive, but not so.

[149] It's like you can have cocaine on this end of the continuum and classic psychedelics here.

[150] Continuum of addiction.

[151] So it's certainly no cocaine.

[152] It's pretty rare for people to get into daily use patterns, but it's possible.

[153] And they can get into more like, you know, using once a week pattern where they can find it hard to stop.

[154] But it's somewhere in between mostly towards to the classic psychedelic side in terms of, like, relatively little addiction potential.

[155] But it's also more physiologically dangerous.

[156] I think that certainly the therapeutic use, it's showing really promising effects for treating PTSD.

[157] And the models that are used, I think those are extremely acceptable when it comes to the risk -benefit ratio that you see all throughout medicine.

[158] But nonetheless, we do know that at a certain dose and a certain frequency that MDMA can cause long -term damage to the serotonin system in the brain.

[159] So it doesn't have that level of kind of freakish, bodily safety that the classic psychedelics do.

[160] And it has more of a heart load, a cardiovascular.

[161] I don't mean kind of emotion in this sense, although it is very emotional.

[162] And that's something unique about its subjective effects, but it's more of a press.

[163] And the terminology using sort of like a freakish capacities allowing you from a researcher perspective, but a personal perspective too of taking a journey with some of these psychedelics that is the heroic dose, as they say.

[164] So like these are tools that allow you take a serious mental journey, whatever that is.

[165] That's what you mean.

[166] And with MDMA, there's a little bit, it starts entering this territory where you've got to be careful about the risks to the body potentially.

[167] So yes, that in the sense that you can't kind of push the dose up as high as safely as one can, if they're in the right setting, like in our research, as they can with the classic psychedelics.

[168] But probably more importantly, just the nature of the effects with MDMA aren't the full on psychedelic.

[169] It's not the full journey.

[170] You know, so it's sort of a psychedelic with rose -colored glasses on.

[171] A psychedelic that's more of, it's been called more of a heart trip than a head trip.

[172] The nature of reality doesn't unravel as frequently as it does with classic psychedelics.

[173] But you're able to more directly sense your environment.

[174] So your perception system still works.

[175] It's not completely detached from reality with MDMA.

[176] That's true, relatively speaking.

[177] That said, at most doses of classic psychedelics, you still have a tether to reality.

[178] It changes a little bit when you're talking about smoking DMT or smoking five methoxy DMT.

[179] which are some interesting examples we could talk more about.

[180] But with MDMA, for example, it's very rare to have what's called an ego loss experience or a sense of transcendental unity where one really seemingly loses the psychological construct of the self.

[181] But MDMA, it's very common for people to have this.

[182] You know, they still are perceiving themselves as a self, but it's common for them to have this warmth, this empathy for humanity and for their friends and loved ones.

[183] So it's more, and you see those effects under the classic psychedelics, but that's a subset of what the classic psychedelics do.

[184] So I see MDMA in terms of its subjective effects is if you think about Venn diagrams, it's sort of MDMA is all within the classic psychedelics.

[185] So everything that you see on a particular MDMA session, sometimes a psilocybin session looks just like that.

[186] But then sometimes it's completely different with psilocybin.

[187] It's a little more narrowed in terms of the variability with MDMA.

[188] Is there something general to say about what the psychedelics do to the human mind?

[189] You mentioned kind of an ego loss experience in the space of van diagrams.

[190] If we're to like draw a big circle, what can we?

[191] say about that big circle?

[192] In terms of people's report of subjective experience, probably one of the most general things we can say is that it expands that range.

[193] So many people come out of these sessions saying that they didn't know it was possible to have an experience like that.

[194] So there's an emphasis on the subjective experience that, is there a words that?

[195] that people put to it, that capture that experience?

[196] Or is it something that just has to be experienced?

[197] Yeah, people.

[198] As a research, it's an interesting question because you have to kind of measure the effects of this.

[199] And how do you convert that into numbers?

[200] Right.

[201] That's the ultimate child.

[202] So is that even, is that possible to one, convert it into words and the second convert the words into numbers somehow so we do a lot of that with questionnaires you know some of which are very psychometrically validated so they lots of numbers have been crunched on them and there's always a limitation with with questionnaires i mean subjective effects or subjective effects ultimately it's what the person is reporting and in that doesn't necessarily point towards a ground truth what what they're so for example if someone says that it they felt like they touched another dimension or they felt like they they sensed the reality of god or if they um you know um i mean just you name it people's ontological views can sometimes shift i think that's more about where they're coming from and i don't think it's the the quintessential way in which they work there's plenty of people that hold onto a completely naturalistic viewpoint and come and and have profound and and helpful experiences with these compounds but the subjective of effects can be so broad that for some people, it shifts their philosophical viewpoint, more towards idealism, more towards, you know, thinking of that the nature of reality might be more about consciousness than about material.

[203] That's a domain I'm very interested in.

[204] Right now, we have essentially zero to say about that in terms of validating those types of claims.

[205] But it's even interesting just to see what people say along those lines.

[206] So you're interested in saying, like, can we more rigorously study this process of expansion?

[207] Like, what do we mean by this expansion of your sense of what is possible in the experiences in this world?

[208] Right, as much as what we can say about that through naturalistic psychology.

[209] Right.

[210] Especially as much as we can root it to solid psychological constructs and solid neuroscientific constructs.

[211] And I want to what the impact is of the language that you bring to the table.

[212] So you mentioned about God or speaking of God, a lot of people are really into sort of theoretical physics these days at a very surface level.

[213] And you can bring the language of physics, right?

[214] You can talk about quantum mechanics, you can talk about general relativity and curvature of space time and using just that language without a deep technical understanding of it to somehow start thinking like sort of visualizing atoms in your head and somehow through that process because you have the language, using that language to kind of dissolve the ego, like realize that we're just all little bits of physical objects that behave in mysterious ways.

[215] And so that has to do with the language.

[216] Like if you read a Sean Carroll book or something recently, it seems like as a huge influence on the way you might experience, might perceive the world and might experience the alteration that psychedelics brings to the to the your perception system.

[217] So I wonder like the language you bring to the table, how that affects the journey you go on with the psychedelics.

[218] I think very much so.

[219] And I think there's, I'm a little concerned some of the science is going a little too far in the direction of around the edges, you know, speaking about it changing beliefs in this sense or sense about particular in particular domains.

[220] And I think what really what a lot of what's going on is what you just discussed.

[221] It's the priors coming into into it.

[222] So if you've been reading a lot of, you know, physics, then you might, you know, bring up, you know, like, you know, space time and interpret the experience in that sense.

[223] I mean, it's not uncommon for people come out talking about visions of the, it's not the most typical thing, but it's come up in sessions I've guided, the Big Bang, and this sort of nature of reality.

[224] I think probably the best way to think about these experiences is that, and the best evidence, even though we're in our infancy and understanding it, they really tap into more general psychological mechanisms.

[225] I think one of the best arguments is they they they reduce the influence of the of our priors of what we bring into the all of the assumptions that we all that you know we're essentially especially as adults we're riding on top of heuristic after heuristic to get through life and and you need to do that and that's a good thing and that's extremely efficient and evolution has shaped that but that comes out an expense.

[226] And it seems that these experiences will allow someone greater mental flexibility and openness.

[227] And so one can be both less influenced by their prior assumptions, but still nonetheless, the nature of the experience can be influenced by what they've been exposed to in the world.

[228] And sometimes they can get it in a deeper way.

[229] Like maybe they've read, I mean, I had a philosophy professor one time as a, as a participant in a high -dose psilocybin study, and he's like, I remember him saying, my God, it's like Hegel's opposites defining each other.

[230] Like, I get it.

[231] I've taught this thing for years and years and years.

[232] Like, I get it now.

[233] And so, like that, you know, and even at the psychological, emotional level, like the cancer patients we worked with, you know, they told themselves a million times over the people trying to quit smoking.

[234] I need to quit smoking.

[235] Oh, I'm ruining my life with this cancer.

[236] I'm still healthy.

[237] I should be getting out.

[238] I'm letting this thing defeat me. It's like, yeah, you told yourself that in your head, but sometimes they had these experiences, and they kind of feel it in their heart.

[239] Like, they really get it.

[240] So in some sense that you bring some prize to the table, but psychedelics allow you to acknowledge them and then throw them away.

[241] So, like, one popular terminology around this in the engineering experience, is first principles thinking, that Elon Musk, for example, espouses a lot.

[242] Let me ask a fun question before we return to a more serious discussion.

[243] With Elon Musk as an example, but it could be just engineers in general, do you think there's a use for psychedelics to take a journey of rigorous first principles thinking?

[244] So like throwing away, we're not talking about throwing way assumptions about the nature of reality in terms of like our philosophy of the way we live day to day life but we're talking about like how how to build a better rocket or how to build a better car or how to build a better social network or all those kinds of things engineering questions I absolutely think there's huge potential there and it's there was some research in the late 60s early 70s that were it was very early and not very rigorous in terms of methods theology, but it was consistent with the, I mean, there's just countless anecdotes of folks.

[245] I mean, people have argued that just, you know, Silicon Valley was, was largely influenced by psychedelic experience.

[246] I remember the, I think the person that came up with the concept of freeware or shareware.

[247] It's like it kind of was generated, you know, out of, or influenced by psychedelic experience, you know, So to this, I think there's incredible potential there, and we know really next, there's no rigorous research on that, but.

[248] Is there anecdotal stuff like with Steve Jobs?

[249] I think there's stories, right?

[250] In your exploration of it, is there something a little bit more than just stories?

[251] Is there like a little bit more of a solid data points, even if they're just experiential, like, anecdotes, is there something that you draw inspiration from, like, in your intuition?

[252] Because we'll talk about you're trying to construct studies that are more rigorous around these questions.

[253] But is there something you draw inspiration from the past from the 80s and the 90s and Silicon Valley, that kind of space?

[254] Or is it just like you have a sense based on everything you've learned and these kind of loose stories that there's something worth digging at?

[255] I am influenced by the, gosh, the, just incredible number of anecdotes surrounding these.

[256] I mean, Carrie Mollis, he invented PCR.

[257] I mean, absolutely revolutionized biological sciences.

[258] He says he wouldn't have won the Nobel Prize from it, said he wouldn't have come up with that had he not had psychedelic experiences.

[259] Now, he's an interesting character.

[260] people should read his autobiography because you could point to other things he was into.

[261] But I think that speaks to the casting your nets wide and this mental flexit, more of these general, these general mechanisms where sometimes if you cast your nets really wide and it's going to depend on the person and their influences, but sometimes you come up with false positives, you know, you connect the dots where maybe you shouldn't have connected those dots.

[262] But I think that can be constrained and so much of our, not only a personal psychological suffering, but our limitations academically and in terms of technology are because of these self -imposed limitations and heuristics, these entrenched ways of thinking.

[263] You know, like those examples throughout the history of science where someone has come up with a rat, the paradigm, Coon's paradigm shifts.

[264] it's like here's something completely different you know this doesn't make sense by any of the previous models and like we need more of those we I mean you know and then you need the right balance between that because so many the you know novel crazy ideas are just bunk and you need that's what science is about separating them from from the valid paradigm shifting ideas but we need more paradigm shifting ideas like in a big way and I think we could I think you could argue that that we've, because of the structure of academia and science in modern times, it heavily biases against those.

[265] Right.

[266] There's all kinds of mechanisms in our human nature that resist paradigm shift quite sort of obviously.

[267] So, and psychedelics, there could be a lot of other tools, but it seems like psychedelics could be one set of tools that encourage paradigm shifting thinking.

[268] So like the first principles kind of thinking.

[269] So it's a kind of, you're at the forefront of research here.

[270] There's just kind of anecdotal stories, there's early studies, there's a sense that we don't understand very much, but there's a lot of depth here.

[271] How do we get from there to where Elon and I can regularly, like I wake up every morning, I have deep work sessions, where it's well understood, like, what dose to take, like, if I want to explore something where it's all legal, where it's all understood and safe, all that kind of stuff.

[272] How do we get from where we are today to there?

[273] Not speaking in terms of legality in the sense, like, policymaking, all that, like, laws and stuff, meaning, like, how do we scientifically understand this stuff well enough to get to a place where I can just take it safe?

[274] safely in order to expand my thinking, like this kind of first principles thinking, which I'm in my personal life currently doing, like, how do I have revolutionized particular, several things?

[275] Like, it seems like the only tools I have right now is just, just.

[276] But my mind going, doing the first principles, like, wait, wait, okay, why has this been done this way?

[277] Can we do it completely differently.

[278] It seems like I'm still tethered to the priors that I bring to the table, and I keep trying to untether myself.

[279] Maybe there's tools that can systematically help me untether.

[280] Yeah.

[281] Well, we need experiments, you know, and that's tied to kind of the policy level stuff.

[282] And I should be clear, I would never encourage anyone to do anything illicitly.

[283] But yeah, you know, in the future, we could see these, you know, compounds used for the, for technical and scientific innovation.

[284] What we need are studies that are digging into that.

[285] Right now, most of what the funding, which is largely fund from philanthropy, not from the government, largely what it's for is treatment of mental disorders like addiction and depression, etc. But we need studies.

[286] You know, one of the early initial stabs on this question decades ago was they took some architects and engineers and said, what problems have you been working on?

[287] Where have you been stuck for months, like working on this damn thing and you're not getting anywhere, like your head's budding up against the wall?

[288] It's like, come in here, take, and I think it was 100 micrograms of LSD.

[289] So not a big session.

[290] And a little bit different model where they were actually working.

[291] it was a moderate enough dose where they could work on the problem during the session.

[292] I think probably, I'm an empiricist, so I'd like to see all the studies done, but the first thing I would do is like a really high dose session where you're not necessarily in front of your computer, you know, which you can't really do on a really high dose.

[293] And then the work has been talked about, like you take a really high dose, you take a journey, and then the breakthroughs come from when you return.

[294] from the journey and like integrate quote unquote that experience i think that's where all the head and again we're we're babies at this point but my gut tells me yeah that that it's the it's the so -called integration the aftermath we know that there's some form different forms of neuroplasticity that are unfolding in the days following a psychedelics at least in animals probably going on humans we don't know if that's related to the therapy effects my my gut tells me it is although it's it's only part of of the story but but we need big studies where we compare people like let's get 100 people like that scientists that are working on a problem and then randomize them to and then I think you need a even more credible you know active controls or active placebo conditions to kind of tease this out and then also in conjunction with that and you can do this in the same study you want to combine that with more rigorous sort of um experimental models where we actually get there are problem solving tasks that we know for example that you tend to do better on after you've gotten a good night's sleep versus not and my my sense is there's a relationship there you know people go back to first principles you know questioning those first principles they're operating under and um you know getting away from their priors in terms of creative problem solving and so you i think wrap those things and you could speak a little more rigorously about those because ultimately if everyone's bringing their own problem that's I think that's more in the face valid side but you can't dig in as much and get as much experimental power and speak to the mechanisms as you can with having everyone do the same sort of you know canned you know problem solving task so we've been speaking about psychedelics generally is there one you find from the scientific perspective or maybe even philosophical perspective most fascinating to study therapeutically I'm most interested in psilocybin and LSD and I think we needed to do a lot more with LSD because it's mainly been psilocybin in the modern era.

[295] I've recently gotten a grant from the HFTA Research Institute to do an LSD study, so I haven't started it yet, but I'm going through the paperwork and everything.

[296] Therapeutic meaning there's some issue and you're trying to treat that issue.

[297] Right, right.

[298] In terms of just like what's the most fascinating, you know, understanding the nature of these experiences, if you really want to like wrap your head around what's going on when someone has a completely altered sense of reality and sense of self.

[299] There, I think you're talking about the, the high dose, either smoked vaporized or intravenous injection, which all kind of, they're very similar pharmacologically, of DMT and five methoxy DMT.

[300] This is like when people, this is what, I don't know if you're familiar with Terrence McKinney, he would talk a lot about smoking DMT, Joe Rogan, has talked a lot about that.

[301] People will say that, and there's a close relative.

[302] called 5 methoxyDMT.

[303] Most people who know the terrain will say that's an order of magnitude or orders of magnitude beyond anything one could get from even a high dose of psilocybin or LSD.

[304] I think it's a question about whether, you know, how therapeutic.

[305] I think there is a therapeutic potential there, but it's probably not as sure of a bet because one goes so far out.

[306] It's almost like, you're not contemplating their relationship and their direction in life.

[307] If they are like, reality is ripping apart at the seams and the very nature of the self and of the sense of reality.

[308] And the amazing thing about these compounds, and same to a less degree with the, you know, with oral cell psilocybin and LSD is that unlike some other drugs that really throw you far out there, you know, anesthetics and even alcohol, like it, as reality starts to become different.

[309] at higher, higher doses, there's this numbing.

[310] There's this sort of, there's this ability for the sense of being the center, having a conscious experience that's memorable that is maintained throughout these classic psychedelic experiences.

[311] Like one can go so far out while still being aware of the experience and remembering the experience.

[312] Interesting.

[313] So being able to carry something back.

[314] Right.

[315] Can you dig in a little deeper?

[316] Like, what is DMT?

[317] How long is the trip usually?

[318] Like, how much do we understand about it?

[319] Is there something interesting to say about just the nature of the experience and what we understand about it?

[320] One of the common methods for people to use it is to smoke it or vaporize it.

[321] And it usually takes, and this is a pretty good kind of description of what it might feel like on the ground.

[322] The caveat is it's a completely insufficient description and someone's going to be listening to it.

[323] It's like nothing you could say is going to come close.

[324] But it'll take about three big hits inhalations in order to have what people call a breakthrough dose.

[325] And there's no great definition of that, but basically meaning.

[326] moving away from you know not just having the typical psilocybin or LSD experience where like things are radically different but you're still basically a person in this reality to go in somewhere else and so that'll typically take like three hits and this stuff comes on like a freight train so one takes a hit and around the time of the first exhalation so we're talking about a few seconds in or maybe just, you know, sometime between the first and the second hit, like, it'll start to come on.

[327] And they're already up to, say, you know, what they might get from a 30 milligram or 300 microgram LSD trip, a big trip.

[328] They're already there at the second hit, but they're going, their consciousness is geared.

[329] This is like acceleration, not speed, to speak of physics.

[330] Okay, it's like you're just, those receptors are getting filled like that.

[331] and they're going from zero to 60 in, like, you know, Tesla time.

[332] Yeah.

[333] And at the second hit, again, they're at this, maybe the strongest psychedelic experience they've ever had.

[334] And then if they can take that third hit, and some people can't, they're, I mean, they're, they're propelled into this other reality.

[335] And the nature of that other reality, it will differ depending on who you ask, but, you know, often talk about and and we've done some survey research on this entities of different types elves tend to pop up yeah all the caveat is i i strongly presume all of this is culturally influenced you know but thinking more about the psychology and the neuroscience there is probably something fundamental you know like for someone that might be colored as elves others it might be colored as um i don't know terence mackina called them self -dribbling basketballs for someone else it might be little animals or someone else it might be aliens um i think that probably is dependent on who they are and what they've been exposed to but just the fact that one has this sense that they're surrounded by autonomous entities right intelligent autonomous entities right and people come back with stories that are just astonishing like there's communication between these And often they're telling them things that the person says are self -validating, but it seems like it's impossible.

[336] Like it really seems like, and again, this is what people say oftentimes, that it's, it really is like downloading some intelligence from higher dimension or some whatever metaphor you want to use.

[337] Sometimes these things come up in dreams where it's like someone is exposed to something that I've had this.

[338] a dream, you know, where it seems like what they are being exposed to is physically impossible, but yet at the same time, self -validating, it seems true, like that they really are figuring something out.

[339] Of course, the challenge is to say something in concrete terms after the experience where you could, you know, verify that in any way.

[340] And I'm not familiar of any examples of that.

[341] Well, there's a sense in which, I suppose, the experience is like you're a limited cognitive creature that knows very little about the world, and here's a chance to communicate with much wiser entities that in a way that you can't possibly understand are trying to give you hints of deeper truths.

[342] And so there's that kind of sense that you.

[343] You can take something back, but you can't, where our cognition is not capable to fully grasp the truth, we'll just get a kind of sense of it, and somehow that process is mind -expanding, that there's a greater truth out there.

[344] Right.

[345] That seems like what, from the people I've heard to talk about, that seems to be what it is.

[346] And that's so fascinating that there's fundamentally to this whole thing, is a communication between an entity that is other than yourself, entities.

[347] So it's not just like a visual experience, like you're like floating through the world, is there's other beings there, which is kind of, I don't know.

[348] I don't know what to sort of, from a person who likes Freud and Carl Jung, I don't know what to think about that.

[349] That being, of course, from one perspective, is just you looking in the mirror.

[350] But it could also be from another perspective like actually talking to other beings.

[351] Yeah, and you mentioned Young, and I think that's, he's particularly interesting, and it kind of points to something I was thinking about saying, is that I think what might be going on from a naturalistic perspective, so regardless, you know, whether or not there are, you know, it doesn't depend on autonomous entities out there, what might be happening is that just the associative net, the level of learning, the the comprehension might be so beyond what someone is used to that the only way for the nervous system for the for the aware sense of self to orient towards it is all by metaphor and so I do think you know when we get into these realms as a strong empiricist I think we always got to be careful and be as grounded as possible.

[352] but I'm also willing to speculate and sort of cast nets wide with caveat.

[353] But, you know, I think of things like archetypes and, you know, it's plausible that there are certain stories, they're certain, you know, we've gone through millions of years of evolution.

[354] It may be that we have certain characters and stories that are sort of, that our central nervous system is sort of wired to tend to.

[355] Yeah, those stories, we carry those stories in us.

[356] Right.

[357] And this unlocks them in a certain kind of way.

[358] And we think about stories.

[359] Like our sense of self is basically narrative self is a story.

[360] And we think about the world of stories.

[361] This is why metaphors are always more powerful than, you know, sort of laying out all the details all the time, you know, speaking in parables.

[362] It's like if you really get something.

[363] You know, this is why as much as I hate it, you know, if you're presenting to Congress or something and you have all the best data in the world, it's not.

[364] as powerful as that one anecdote as as as the mom dying of cancer that had the psilocybin session and it transformed her life you know that's a story that's meaningful and so when this kind of unimaginable kind of change and and experience happens with a DMT um ingestion it these stories of entities they might they might be that you know stories that are constructed that is the the closest, which is not to say the stories aren't real.

[365] I mean, I think we're getting to layers where it doesn't really, right.

[366] Yeah, yeah.

[367] But it's the closest we can come to making sense out of it.

[368] Because I do, what we do know about these psychedelics, one of the levels beyond the receptor is that the brain is communicating it with itself in a massively different way.

[369] There's massive communication with areas that don't normally communicate.

[370] And so it, I think that comes with both its characteristics.

[371] Casting the nets wide, I think that comes with the insights and helpful novel ways of thinking.

[372] I do think it comes with false positives.

[373] You know, that could be some of the delusion.

[374] And so, you know, when you're so far out there, like with DMAT experience, like maybe alien is the best way that the mind can wrap some arms around that.

[375] So I don't know how much you're familiar with Joe Rogan.

[376] But he does bring up DMT quite a bit.

[377] It's almost a meme.

[378] It is a name.

[379] Have you ever, what is it?

[380] Have you ever tried DMT?

[381] I mean, I think he talks about this experience of having met other entities.

[382] And they were mocking him, I think.

[383] If I remember the experience correctly, like laughing at him and saying FU, FU or something like that.

[384] I may be misremembering this, but there's.

[385] in general mockery, and what he learned from that experience is that he shouldn't take himself too seriously.

[386] So it's the dissolution of the ego and so on.

[387] Like, what do you think about that experience, and maybe if you have more general things about Joe's infatuation with DMT, and if DMT has that important role to play in popular culture in general?

[388] I'm definitely familiar with it.

[389] I remember telling you offline that when I've first the first time I learned who Joe Rogan was probably 15 years ago, and I came upon a clip, and I realized there's another person in the world who's into both DMT and Brazilian Jiu -Jitsu.

[390] And I think both those worlds have grown dramatically since, and it's probably not such a special club these days.

[391] So he definitely, you know, got onto my radar screen quickly.

[392] You were into both before it was cool.

[393] Right.

[394] I mean, you know, this is all relative because there's people that were, you know, before the late 90s and early 2000s who were into it and say you know you're a johnny come lately but but yeah compared to where we're at now but yet one of the things always found fascinating by by joe's you know um telling of his experience experiences i think is that they resemble very much terence mckenna's experiences with dmt and joe has talked very much about terence mckenna and his experiences if i had to guess i would guess that probably just having heard Terrence McKenna talk about his experiences that Joe's, that that influenced the coloring of Joe's experience.

[395] It's funny.

[396] It's funny how that works because, I mean, that's why McKenna hasn't, I mean, poets and great orders give us the words to then, like, start to describe our experiences because our words are limited, our language is limited.

[397] And it's always nice to get some kind of nice poetry into the mix to allow us to put words to it.

[398] Right.

[399] And he, but I also see some elements that, that, that, that seem to relate to Joe's psychology, get just from what I've seen in him, you know, from hours of, of watching him on his podcast, is that, you know, he's a self -critical guy.

[400] Yes.

[401] And I think with always his positive, Ben, I'm always struck being a behavioral pharmacologist, and he, no one else really says it about cannabis.

[402] I'll get back to the D &T thing about, he likes the kind of the paranoid side of things.

[403] He's like, that's you radically examining yourself.

[404] Yeah.

[405] It's like, that's not just a bad thing.

[406] That's you need to, like, look hard at yourself.

[407] And something's making you uncomfortable, like, dig into that.

[408] And, like, that's his, it's sort of along the lines of Goggins with exercise.

[409] And it's like, yeah, like, things, learning experiences aren't supposed to be easy.

[410] Like, take advantage of these uncomfortable experience.

[411] It's why we call in our research in a safe context with psychedelics, they're not bad trips.

[412] They're challenging experiences.

[413] Nice, yes.

[414] So.

[415] Yeah, it's fascinating.

[416] Just that's a tiny tangent.

[417] it's always cool for me to hear him talk about marijuana, like weed, as the paranoia, the anxiety or whatever that you experience as actually the fuel for the experience.

[418] Like I think he talks about smoking weed when he's writing.

[419] That's inspiring to me because then you can't possibly have a bad experience.

[420] I'm a huge fan of that.

[421] Like every experience is good.

[422] Right, which is very Goggins.

[423] Yeah, it's very Goggins.

[424] Yeah, is it bad?

[425] Okay, all right, great, you know.

[426] Well, see, Gagas is one side of that.

[427] He wants it bad.

[428] Like, he wants the experience to be challenging always.

[429] But, I mean, like, both are good.

[430] Like, the few times of taking mushrooms, the experience was, like, everything was beautiful.

[431] There's zero challenging aspect to it.

[432] It was just, like, the world is beautiful, and it gave me this deep appreciation of the world.

[433] I would say, so like that's amazing, but also ones that challenge you are also amazing, like all the times I drink vodka, but that's another, let's not.

[434] So back to DMT.

[435] Yeah, Joe's treating, you know, cannabis as a psychedelic, which is something that I'd say, like a lot of people treat it more like Xanax or like beer, you know, or vodka.

[436] But he's really trying to delve into those, the minor, It's been called a minor psychedelic.

[437] So with DMT, you know, as you brought up, it's like the entity's mocking him.

[438] And it's like, you're not good.

[439] I mean, this reminds me of him, you know, him describing his, like, you know, writing his, or just his entire method of, of comedy.

[440] It's like, watch the tape of yourself.

[441] You know, don't just ignore it.

[442] Like, that's where I screwed up.

[443] That's where I need to do better.

[444] This, like, sort of radical self -examination, which I think our society is kind of getting away from because, like, You know, all the children win trophies type of thing.

[445] You know, it's like, no, no, don't go overboard, but, like, recognize when you've messed up.

[446] Yes.

[447] And so, like, that's a big part of the psychedelic experience.

[448] Like, people come out sometimes saying, my God, I need to say sorry to my mom.

[449] Yeah.

[450] You know, like, it's so obvious.

[451] Like, or whatever, you know, interpersonal issue or, like, my God, I don't, I'm not pulling enough weight around the house and helping my wife.

[452] and, you know, these things that are just obvious to them, the self -criticism that can be a very positive thing if you act on it.

[453] You've mentioned addiction.

[454] Maybe we could take a little bit detour into a darker aspect of things, or not even darker, it's just an important aspect of things.

[455] What's the nature of addiction?

[456] You've mentioned some things within a big umbrella of psychedelics, may be usually not addictive, but maybe MDMA, I think you said, might have some addictive properties, but the point is stuff outside of the psychedelics umbrella can often be highly addictive.

[457] So you've studied addiction from several angles, one of which is behavioral economics.

[458] What have you understood about addiction?

[459] What is addiction from the biological, physiological level to the psychological to whatever is the interesting way to talk about addiction yeah and i the lenses that i view addiction through very much are behavioral economic but i also think they converge on i think it's beautiful at the other end of the spectrum sort of just a completely um humanistic psychology perspective um and i it converges on what people come out of you know 12 step meetings talking about can you uh can you say what is behavioral economics and what is humanistic psychology?

[460] What do you mean by that?

[461] And more importantly, behavioral economics lens, what is that?

[462] Yeah, so behavioral economics, my definition of it is the application of economic principles, mostly microeconomic principles, so understanding the behavior of individual agents surrounding, you know, commodities in the marketplace, applying microeconomic types of analyses to, non -economic behavior.

[463] So basically at one point, like psychologists figured out that there's this whole other discipline that's been studying behavior, it just happened to be all focused on monetary behavior, spending, and saving money, et cetera.

[464] But it comes with all of these like principles that can be wildly and fruitfully applied to understanding behavior.

[465] So, so for example, I've studied things like demand curve analysis of drug consumption.

[466] So I look at for example, the tobacco, cigarettes, and nicotine products through the lens of demand curves.

[467] And in other words, at different prices, if there's different work requirements for being able to smoke cigarettes, sort of modeling price.

[468] Within that price data, there is some indication of addiction, how much you, the habits that you form around these particular drugs.

[469] Yeah, it's one important to make.

[470] mentioned.

[471] So I think a particularly important one there is elasticity or inelasticity, you know, two ends of the spectrum.

[472] So that's the price sensitivity.

[473] So for example, you could have something that's pretty price inelastic like gasoline.

[474] So the price of gas at times can keep going up and Americans are just going to pretty much buy the same amount of gas.

[475] Or maybe, you know, the price of gas doubles, but their consumption only decreases by 10.

[476] So it's a sub -proportional reduction.

[477] So that's an inelastic.

[478] And that changes.

[479] Like you push the price up high enough.

[480] I mean, if it was $100 a gallon, it would eventually turn.

[481] The curve would turn and go downward more drastically, and it would be elastic.

[482] But you can apply that to someone, you know, someone who, regular cigarette smoker who is working for cigarette puffs, who has who's gone six hours without smoking.

[483] And you're asking questions like, you know, how many times are they willing to pull?

[484] this knob in the lab during this three -hour session.

[485] I do a lot of work like this in order to earn a cigarette pot.

[486] How does the content of nicotine in that effect?

[487] It has the availability of nicotine replacement products like nicotine gum or e -cigarettes affect those decisions.

[488] So you can, it's a certain lens of, it's sort of a way to take the kind of the classic behavioral psychology definition of reinforcement, and which is just basically reward, you know, how much is this a good thing?

[489] And it kind of, breaks that apart into a multi -dimensional space.

[490] So it's not just the idea's reward or reinforcement is not unidimensional.

[491] So, for example, you can unpack that with demand curves.

[492] At a cheap price, you might prefer one good to another.

[493] You know, so the classic example is luxury versus necessity.

[494] It's a diamonds versus toilet paper.

[495] So at those cheap prices, you can look at something called intensity of demand.

[496] you know if it was basically as cheap as possible or essentially zero how much would you buy of this good but then you keep jacking up the price and you'll see so diamonds will look like the better reward at that at that low price sort of intensity of demand side of things but as you keep jacking up the price you got to have some toilet paper yes okay we can get into the whole like bidet thing but forget that you know like uh i know joe's been pushing that too but you know you're gonna you're gonna you're gonna hang on and keep buying the toilet paper to a greater degree than you will the diamonds yes so you'll see a crossing of demand curves so what's the better reinforcer what's the better reward depends on your price you know and so that's one that's an example of one way to and that of look at addiction so specifically drug consumption which is isn't all of addiction but it's like in order for something to be addictive it has to be a reward and it has to compete with other rewards and in your life and and one of the two main aspects of addiction in my in my view and this doesn't map on to how the you know the DSM the psych psychiatry Bible defines addiction which I think is largely bunk you know but there's some value to have some common description but it's you know how rewarding is it from this multi -dimensional lens and specifically how does it how does that rewarding value compete with other rewards other consequences?

[497] in your life so it's it's not a problem if if the use of that substance is rewarding you know okay yeah you like to have a couple beers every once in a while it's like not a problem i mean um but then you have the alcoholic who is drinking so much that they they they're they're it tanks their career it ruins their marriage it's in competition with these pro -social aspects to their life it's all about compare to the other choices you're making the other activities in your life, and if you evaluate it as a much higher reward than anything else that becomes an addiction.

[498] Right, right.

[499] And so it's not just the rewarding value, but it's the relative rewarding value.

[500] And in the other major, again, from behavioral economics, the thing that makes addiction is something called delayed discounting.

[501] So in economics, sometimes it's called time preference.

[502] It's what compound interest rates are based upon.

[503] It's the idea that delaying a good, access to a good or a reward comes with a certain decrement to its value.

[504] So we'd all rather have things now than later.

[505] And we can study this at the individual level of, you know, would you rather have $9 today or $10 tomorrow?

[506] And, and And when you do that, you get huge differences between addicted populations and non -addicted, not just heroin and cocaine, but like just cigarette smokers, like normal, everyday cigarette smokers.

[507] And even when you look at something like, you know, monetary rewards.

[508] And so you can go into the rabbit hole with this delay discounting model.

[509] So it's not only those huge differences that seem to have a face valid aspect to it, like the cigarette smoker is choosing this thing that's rewarding.

[510] today, but I know it comes with increased risk of having these horrible consequences down the line.

[511] So it's this competition between what's good for me now and what's good for me later.

[512] And the other aspect about delayed discounting is that if you quantitatively map out that discounting curve over time, so you don't just do the, you know, how much, you know, that $10 tomorrow, how much is it worth to you today?

[513] So you can say, what about nine, what about eight, What about $7?

[514] And you can titrate it to find that indifference point.

[515] And so we can say, aha, $6, you know, $10 tomorrow is worth $6 to today.

[516] So it's by the one day, it's decreased by 40%.

[517] We can do that also at one week and one month and one year and 10 years and map out that curve.

[518] Get a shape of that curve.

[519] And one of the fascinating things about this is that whether you're talking about pigeons, making these types of choices between a little bit of food now or a little bit of food minute from now or rats or every like dozens of species of animals tested including humans the tendency is pretty consistently that we we discount hyperbolicly rather than exponentially and what exponentially means is that every unit of time is associated with the same proportional reduction every unit of delay is is associated with the same causes the same proportional reduction in value and that's the way the compound interest rate you know works you know, you know, there's, you know, compound, every day, you know, you get this sort of out of the, whatever values in there at the beginning of that day, you get this, you know, we'll give you this amount of extra money to compensate you for that delay.

[520] But then the way that all animals tend to function is of this very different way where the reductions, the initial, that initial delay, so like one day's worth of delay, you see a much stronger discounting rate or reduction.

[521] and value, then you do over those, so you see the super proportional, then it changes to these lesser rates.

[522] And so the implication of that, I know I've gone like really into the weeds quantitatively, but what that means is that there's these preference reversals.

[523] When you have curves of that nature, the decay that's hyperbolic, it maps onto this phenomenon we see both in terms of how people deal with future rewards, but also how perception works.

[524] When two things are far away, whether it's physical distance or whether in terms of perception or whether it's in terms of time, when you're really far away, the value, the subjective value for that further, that delayed reward is larger.

[525] So, for example, like, let's say we're talking about 360, 364 days from now you can get $9 or 365 days a year.

[526] Now you get $10 and you're like, it's like, it's a year.

[527] Like, no difference.

[528] Like, I'll take, why not get one more dollar?

[529] Yeah.

[530] You bring that same exact set of choices closer.

[531] Nothing's changed other than the time to both rewards.

[532] And it's like, would you rather have $9 today or $10 tomorrow?

[533] and plenty of people would say, eh, about the sound, just go ahead and take it today.

[534] Yeah.

[535] So you see this preference reversal.

[536] And so that is, that's a model of addiction in the sense that consistently, with true addiction, I would argue, you see this competition between molar and molecular utility.

[537] It's like intrapersonal, like within the person competing agents, someone sometimes has control of the bus that wants to do what's good for you in the short term and someone's other times isn't control of driving the bus and they want to do what's good for you in the long term so you tell the you know you're trying to quit and you see a doctor you see your you know 12 -step therapist and say god i know this stuff is killing me like i'm really i'm on the path i'm like i'm done and that's when you're kind of in their office or where wherever you're not, you know, it's not around you.

[538] And then later on that day, your buddy says that, hey, man, I just scored.

[539] I got it right here.

[540] Do you want it?

[541] And that reward is right in front of you.

[542] That's like bringing those two choices right in front of you.

[543] And it's like, hell, yeah, I want to use.

[544] And then you can go through that cycle for like years of the person telling themselves, I want to quit.

[545] But then other times that same person is saying, I don't want to, you know, functionally, they're saying I don't want to because they're saying, yeah, like, yeah, give me some.

[546] So in the moment, it's very difficult to quit.

[547] and this isn't just something this is something that has has huge clinical ramifications with addiction but it's like all humans do it anyone who's had hit the snooze alarm in the morning like yeah the night before they realize oh i got to get up extra early tomorrow that's what's ultimately better for me so i'm going to set the alarm for you know five a m yes um and they they it goes off at 5 a .m you know and then so now those two consequences have come sooner and it's like what the hell and they hit the snows news alarm and sometimes not just once but then five minutes later and five minutes later you know and so and it's why it's easier to exercise self -control at the grocery store compared to in your fridge like if that snack is like 30 seconds away in your fridge you're going to more likely um yield to temptation than if it is further away so then to take a step back to something you brought up earlier the inelasticity of pricing, is it from a perspective of the dealers, whether we're talking about cigarettes, or maybe venturing slightly into the illegal realm of people who sell drugs illegally, they also have an economics to them, that they set prices and all those kinds of Does addiction allow you to mess with the nature of pricing?

[548] So I kind of assume that you meant that there's a correlation between things you're addicted to and the inelasticity of the price.

[549] So you can jack up the price.

[550] Is there something interesting to be said both for legal drugs and illegal drugs about the kind of price games you can play?

[551] because the consumers of the product are addicted.

[552] Right.

[553] I mean, I think you just described it.

[554] Yeah, you can jack up the price and, you know, some people are going to drop off, but the people, you know, and it's not dichotomous because you can just consume less.

[555] But some people are going to consume less and the people that are most addicted are going to keep, you know, I mean, you see this, they're going to keep, you know, purchasing.

[556] So you see this with cigarettes.

[557] And so it's interesting when you interface this with policy.

[558] like in one respect heavily taxing cigarettes is a good thing we know it keeps you know adolescents particularly price sensitive so you definitely people smoke less and especially kids smoke less when you keep cigarette prices high and you tax the hell out of them but one of the downsides you've got a balance and keep in mind is that you disproportionately have working class poor people and then you get into a point where someone spending you know a quarter of their paycheck on cigarettes they're going to smoke no matter what and basically because they're addicted they're going to smoke them out of what and you're just yeah you're taxing their existence right so you're making it worse for if they don't if they are completely inelastic you're actually making that person's life worse yeah because we know that that by by interfering with the amount of money they have you're interfering with the other um pro social the potential competitors to smoking you know um and we know that when someone's in more impoverished environments and they have less sort of non -drug alternatives, you know, the more likely they're going to stay addicted.

[559] So, you know.

[560] Is there a data, this is interesting, from a scientific perspective, of those same kind of games in illegal drugs, sort of, because that's where most drug, I was, I mean, I don't know, maybe you can correct me, but it seems like most drugs are currently illegal.

[561] and so but they're still in economics to them obviously that's the drug war and so on is there data on the setting of prices or like how good are the business people running the selling of drugs that are illegal are they all the same kind of rules apply from the behavior economics perspective i think so i mean they're basically that whether they're crunching the numbers or not they're basically sensitive to that demand curve and they're doing the the same thing that businesses do in a legal market and you know you want to sell as much of a product to get as much money you're looking more at the total income so if you jack the price a little bit you're going to get some reduction in consumption but it may be that the total amount of money that you rake in is going to be more than then it's going to overcompensate for that so you're willing to take okay i'm going to lose 10 % of my customers but i'm getting more you know more than enough to compensate from that from the extra money from the people who still are buying so i think they're more you know and especially when we get to the lower i wouldn't be surprised if people are crunching those numbers and looking at demand covers maybe at the you know at the really high levels of the you know up the chain with the cartels and one i don't know i that wouldn't surprise me at all but i think it's probably you know more implicit at the at the lower levels where um something he brought up drug policy i will say that i for for years now it's been this kind of unquestioned goal by, for example, the drugs czar's office in the U .S. to make the price of illegal drugs as high as possible without this kind of nuanced approach that, yeah, if you make, you know, for some people, if you, you know, if you make the price so high, you're actually making things worse.

[562] I mean, I'm all about reducing the problems associated with drugs and drug addictions.

[563] And part of that is that are more direct consequences of those.

[564] drugs themselves.

[565] But a whole lot is what you get from indirectly and, you know, sort of both for the individual and for society.

[566] So like making it a poor person who doesn't have enough money for their kids, making them even poorer.

[567] So now you've made their children's future worse because they're growing up in deeper poverty because you've essentially levied a tax onto this person who's heavily addicted.

[568] But then at the societal level, you know, so everything we know about the drug war in terms of the heavy criminalization and filling up prisons and reducing employment and educational opportunities, which in the big picture, we know are the things that in a free market compete against some of the worst problems of addiction is actually having educational and employment opportunities, but when you give someone a felony, for example, you're pretty much guaranteeing they're never going to go very high on the economic ladder.

[569] And so you're making drugs a better reward for that person's future.

[570] So this is a quick step into the policy around, and I think for both you and I, I'm not sure you can correct me, but I'm more comfortable into studying the effects of drugs on the human behavior and human psychology versus like policy.

[571] It seems like a whole giant mess.

[572] But, you know, there's some libertarian candidates for president and just libertarian thinkers that had a nice thought experiment of possibly legalizing, I've spoken about possibly legalizing basically all drugs.

[573] In your intuition, do you think a world where all drugs are legal is a safer world or a less safe world for the users of those?

[574] drugs.

[575] It really depends on what we mean by legalization.

[576] So this is one of my beefs with this, you know, how these things are talked about.

[577] I mean, we have very few completely laissez -faire, you know, legal drugs.

[578] So even caffeine is one of the few examples.

[579] So for example, caffeine and tea and coffee is in that realm.

[580] Like there's no limits.

[581] No one's testing.

[582] There's no laws regulation at any level of how much caffeine you're allowed to buy or how much But even like with this Starbucks, like Nitro, there are rules with soda and with canned products.

[583] You can only put so much in there, yeah.

[584] Yeah, so this is FDA regulated.

[585] And it's kind of weird because there's a limit to sodas that's not there for energy drinks and other things.

[586] So, but, you know, so even caffeine, it depends on what product we're talking about.

[587] Like, if you're like no dose and other caffeine products over the counter, like you can't just put 800 milligrams in there.

[588] The pills are like one or 200 milligrams.

[589] And so it's FDA regulated as no recounted drug.

[590] some of the most dangerous drugs in society, I would say arguably one of the most dangerous classes of drugs of the volatile anesthetics, huffing, people huffing gasoline and airplane glue, toluene, whatnot, severely damaging to the nervous system, pretty much legal, but there's some regulation in the sense that there's a warning label, like it's illegal to do it for not that it necessarily people, they're busting people for this, but, you know, it's against federal law to use this in a way other than intended type of the basic thing like yeah don't huff this you know um your paint thinner or whatnot at least keeps people from selling it for that like no because they're going to they're going to go after that person they're not going to be able to find the 12 year old who's huffing yeah so anyway just as some extreme examples at at the end and then you know even the the so -called illegal like schedule one drug psilocybin we do plenty in and um in terms of schedule two which is like ironically, less restrictive than psilocybin, but methamphetamine and cocaine I've done human research with.

[591] My research has been legal, so they're scheduled compounds, but they're not completely illegal.

[592] Like, you can do research with them with the appropriate licenses and approval.

[593] So there really is no such thing.

[594] And like alcohol, well, it's illegal if you're 12 years old or 18 years old or 20 years old.

[595] And for anyone, it's illegal to be drinking it while you're driving.

[596] So there's always a nuance.

[597] It's not dichotomy.

[598] And I actually should admit, it's been on my to do list for a while to buy in Massachusetts some, like, edible or just buy weed legally.

[599] I, yeah, haven't done that in Massachusetts, let's put it this way.

[600] And I wonder what that experience is like, because I think it's fully legal in Massachusetts.

[601] And so I wonder what legal drugs look like to me. You know, I grew up with even weed being like, you know, not, it's like this forbidden thing.

[602] You know, not forbidden, but it's illegal.

[603] You know, most people, of course, I never partook, but most people I knew would attain it illegally.

[604] And so that big switch that's been happening across the country, there's like federal stuff going on to make marijuana legal federally.

[605] I'm half paying attention.

[606] There's some movement there.

[607] I mean, the House passed a bill that's not going to be passed by the Senate.

[608] But, yeah, it's progress.

[609] There's clearly a change.

[610] Right.

[611] It's moving in a trend.

[612] So that's the example of a drug that used to be illegal and is not becoming more and more and more legal.

[613] So, like, I wonder what, like, cocaine being legal looks like.

[614] Right.

[615] What a society with cocaine being legal looks like.

[616] The rules around it, you know, the processes in which you can consume it.

[617] in a safer way and be more educated about its consequences, be able to control dose and purity much better, be able to get help for overdose, I don't know, all those kinds of things.

[618] It does, in a utopian sense, feel like legalizing drugs at least should be talked about and considered versus keeping them in the dark.

[619] I agree.

[620] But yeah, so that, In your sense, it's possible that in 50 years we legalize all drugs and it makes for a better world.

[621] The way I like to talk about it is that I would say that we, it's possible and it would probably be a good thing if we regulate all drugs.

[622] How would you regulate, like cocaine, for example?

[623] Is there ideas there?

[624] So, yeah, and you were already, you know, going, you know, where I was going with that kind of first I described how there's always a new ones.

[625] And even like the cannabis in Massachusetts, federally illegal.

[626] So for example, if I was like, and I, you know, colleagues that do cannabis research where they get people high in the lab, like you're a federal funded researcher with NIH funds.

[627] You can't get that stuff from the dispensary because you're breaking a federal law, even though the feds don't have the resources to go after.

[628] They don't want the controversy at this point to go after the individual users or even the sellers in those legal states.

[629] So there's always this nuance, but it's it's about the right regulation.

[630] So I think we already know enough that, for example, like, I think safe injection sites for hard drugs makes a lot of sense.

[631] Like, I wouldn't want heroin and cocaine at the convenience stores.

[632] And I don't think maybe there's some extreme libertarians that want that.

[633] I think even the folks that identify as libertarians, probably most of them don't, well, I don't know.

[634] Like, not all of them want that, you know.

[635] I think, you know, that as a form of regulation, like, look, if you're using these hard drugs, drugs on a on a regular basis you're putting yourself at risk for lethal overdose you're putting yourself at risk for catching HIV and and hepatitis um if you're going to do it if you're doing it anyway come to this place where at least you're not like you know like pulling the the water out of like you know the puddle on the side of the street yeah so it's done by professionals and those professionals are able to educate you also so like a 7 -11 clerk may not be both capable of helping you to inject the drug properly but also won't be equipped to educate you at but the negative consequences all those kinds of things that's a huge part of it the education but then i i think with the opioids like the big part of it is just like with naloxone which is an antagonist it goes into the um the receptor it's called narcan that's the trade name but it's what they revive people on an opioid overdose that's almost completely effective Like, if there's a medical professional there and someone's Odeeing on an opioid, they're virtually guaranteed to live.

[636] Like, that's remarkable that if 100 % at the opioid crisis, you know, if all of those people right now that are dying were doing that in the presence of a medical professional, like even like a nurse with Narcan, there'd be basic almost no deaths.

[637] There's always some exceptions, but, you know, almost no deaths.

[638] Like, that's staggering to me. So the idea that people are doing this, you know, that we could have that level.

[639] of positive effect without encouraging the drug and this is where like you get into this like terrain of like sending the wrong message and it's like no you can do that you can say like we're not encouraging this in fact probably one of the greatest advertisements for not getting hooked on heroin is like visiting a methadone clinic visiting a safe injection site like like this is not like an advertisement for getting hooked on this drug but knowing that we can save people now you have a landscape here because a lot of times it's just like supervised injection but you bring your own stuff you know you bring your own heroin which could still be you know dirty and and and filled with fentanyl and fentanyl derivatives which because of the incredible potency and the more difficulty measuring it it's and some differences at the receptor like you may be more likely you are more likely on average to lethally overdose on it you know so you you could the the level that's been more explored in Switzerland is uh in some places is is you actually provide the drug itself and you supervise the injection so I don't do you like that idea yeah I did public health data are completely on the side of there there's really no credible evidence to this if we allow that we're sending the wrong message and everyone's going to I mean I'm not showing up like you know and it's different by drug like yeah you you legal a lot you set up cannabis shops and some people are going to say so you go I'm going to go there I don't think a whole lot of people are going to go to one of places and say I'm going to shoot up heroin for the first time because and even if like you know it's a country of 300 million people like even if someone does that you have to compare this to the every day people are dying from opioid overdoses like people's kids people's uncles people's like these are real lives that are being shattered so you just look at that and then the other thing and I know this from having done residential even like non -treatment research where we just have a cocaine user or something, stay on our inpatient ward for a month and you really get to know them and sometimes you see, like, oftentimes that's the first time this person has had a discussion with a medical professional, any type of professional in their entire life around their drug use.

[640] Yeah.

[641] Even if they're not looking to quit.

[642] And it's like I, you know, you could imagine that in these safe injection settings where it's like, it might be a year into treatment and they're like, you know, Doc, I know you're not the cops.

[643] Like you really care for me. Like, I think I'm ready to try that methadone thing.

[644] I think I'm really, I think I want to be done.

[645] Just having a conversation about it, yeah.

[646] Yeah, they get to trust the people and realize that they're there because they truly, like, they have a compassion, a love for this community, like, as human beings, and they don't want people to die.

[647] And you get real human connections.

[648] And that, and again, like, those are the conditions where people are going to ultimately seek treatment.

[649] And not everyone always will, but you're going to get that.

[650] And then, you know, you're going to get people like looking into treatment options.

[651] And sometimes, you know, maybe it's years into the treatment.

[652] So it's like there's just all of these indirect benefits that I think at that level, I don't know if you'd call that legalizing.

[653] You know, I think again, at least well regulated.

[654] Right.

[655] Whatever that word is.

[656] Yeah, well regulated, but out in the open.

[657] Right.

[658] Minimizing as many harms as we can while not encouraging.

[659] I mean, we don't encourage people to drink all the, I mean, people die every year from caffeine overdose.

[660] Like, you know, and there's different ways.

[661] to like, you know, just by allowing something doesn't mean we're sending the message that, you know, by saying we're not going to give you a felony, which is actually often the penalty for psychedelics.

[662] I just actually testify for the Judiciary Committee, the Senate, the Assembly in New Jersey.

[663] And just to move psilocybin from a felony to misdemeanor, they use different language in New Jersey.

[664] It's weird, but like the equivalent of felony and misdemeanor.

[665] And that was like two people didn't vote for that on the, on this committee because it was might one of them said it might be sending the wrong message and it's like a felony i mean there's real harms like that's the scarlet letter the rest of your life you're stuck at the lower ends of the employment ladder you're not going to get you know loans for education all of this maybe because of a stupid mistake you made once as a 19 year old yeah doing something that like you know a presidential candidate could have done and admitted to and had no problem you know yeah what drug is the most addictive the most dangerous in your view not maybe like not technically like specifically which drug but more like in our society today what is a highly problematic drug we talked about psychedelics not being that addictive on the other flip side of that you mentioned cocaine is that is that the top one is there something else else that's a concern to you it depends and you've already alluded to this nuance it depends on how you define it if we're talking about on the ground today yes and you know uh modern society i'd i'd say nicotine tobacco oh interesting um i mean in terms of mortality it kills it kills far more than any other drug known to humankind four times more than alcohol like half million deaths in the U .S. every year and about five to six million worldwide due to tobacco.

[666] That's four times more in the U .S. than alcohol.

[667] And if you graph all of the drugs legal and illegal, like, you know, put all of the illegal drugs in like one category on that figure and you put alcohol and tobacco on that figure, all the illegal drugs combine barely, they're a barely visible blip to this incredible, like it's, there's no, even all of the opioid epidemic.

[668] rolled up along with cocaine and everything else, the meth, barely shows up compared to tobacco.

[669] That's one of those uncomfortable truths that I don't know what to do with.

[670] It's like where everybody's freaking out about coronavirus, right?

[671] And nobody's...

[672] It's all relative.

[673] If you look at the relative thing, it's like, well, why aren't we freaking out about cigarettes, which we are increasingly so over the historically speaking, right?

[674] it's like terrorism versus swimming pools i remember that being back in the after the war and terror started it's like yeah there's not even comparison okay so you know that's a little sobering truth there because i was thinking like cocaine i was thinking about all these hard drugs but the reality is relatively nicotine is the is the big one and you didn't ask about mortality or deaths you asked about addiction but that's that really is hard to hard to evaluate it gets into those nuances I spoke of before about there's not a unidimensional way to measure reinforcement.

[675] It kind of depends on the situation and what measure we're looking at.

[676] But, you know, more people have access to tobacco.

[677] And I'm not advocating that we make it an illegal drug.

[678] I think that would be a horrible mistake.

[679] Although there is a very credible push to mandate the reduction of nicotine in cigarettes, which I have, most scientists that study it are for it, I think, think there's some real dangers there because I see that in the broader history of drug use.

[680] It's like when has drug prohibition worked, broadly speaking?

[681] And it's, to me, that would, that path would only make sense in very good conjunction with e -cigrats, which once they're fully regulated, can be a safer, not safe, but much safer alternative.

[682] And if we don't, if we tax the hell out of e -cigarettes and ban every attractive feature like flavors and everything, then that's going to push people to a black market if they can't get the real thing from real, like some people will just quit straight out.

[683] But I think what the regulators and what a lot of scientists that study tobacco like myself, it's a big part still of what I study, they're not used to thinking about the like tobacco really as a drug, largely speaking, in terms of, you know, for example, the history of prohibition.

[684] And I think of like, we already know there's an illicit market, a black market for.

[685] tobacco to get around you know taxes I mean and for selling even loose cigarettes that's what initially caused in Staten Island the police to approach was it Eric Garland who was selling loose cigarettes and he got choked out I mean the thing that caused that police contact was he was selling well I think report it to sell individual cigarettes for like you know you can sell for court it happens in Baltimore and it's like that's technically illegal but you know are you not going to have massive boats of you know supplies coming over from China and elsewhere of real deal cigarettes if you ban, you know, the sale of nicotine.

[686] Like, it's obviously going to happen.

[687] And you have to weigh that against, you know, you're going to create a black market to one size or another.

[688] And your intuition, that really hasn't worked throughout the history when we've tried it.

[689] Right.

[690] But I see a potential path forward, but only if it's well, if it's not in conjunction with e -cigarettes.

[691] If there's a clear alternative, that's a positive alternative, that it kind of stares the population that right uh detour as an alternative yeah the difference here the unique thing that could be taken advantage of here is nicotine is by and large not what causes the harm it's the aromatic hydrocarbons it's the the carcinogens and in tobacco it's burning tobacco smoke it's not the nicotine so um that it's not like alcohol prohibition where like you know you couldn't create the adules the near beer is not going to have the alcohol and so people Like, here you do have the possibility of giving another medium the ability to deliver the drug, which still aren't, to a lot of people, isn't preferred to the tobacco, but nonetheless, again, if you overregulate those and make them less attractive, like if you aren't thoughtful about the nicotine limits and thoughtful about whether you're allowing flavors and everything.

[692] And if you overtax them, you're actually decreasing the ability to compete with the more dangerous product.

[693] So I feel like there is a potential.

[694] path forward but I don't have a lot of confidence that that's going to be done in a thoughtful analytical way and I'm afraid that it could decrease the increase the black market calls all of the harms like every other drug we're moving away from the heavy from the prohibition model slowly but the big barge ship is like making a very slow turn and like okay we really had to step back and question if we went with nicotine tobacco are we moving into that direction like yeah it doesn't quite make sense you uh you've done a study on cocaine and sexual decision making uh can you explain can you explain the findings i mean uh in a broad sense how do you do a study that involves cocaine and uh the other how do you do a involving this sexual decision making and then how do you do a study that combines both yeah sex and drugs too i'm just missing the rock and roll it's the two controversial rock and roll isn't very controversial yeah yeah so the cocaine you know lots of hoops to drum through you got to have a lot of medical support you got to be at a basically an institution a research unit like i'm at that has a long history um and the ability to to do that um uh and you get ethical approval, get FDA approval, but it's possible.

[695] And whenever you're dealing with something like cocaine, you would never want to give that to someone who hasn't already used cocaine.

[696] And you want to make sure you're not giving it to someone who's an active user who wants to quit.

[697] So the idea is like, okay, if you're using this type of drug anyway and you're, we're really sure you're not looking to quit, hey, use a couple times in the lab with us so we can at least learn something.

[698] And part of what we learn is maybe to help people not use and it'll reduce the harms of cocaine.

[699] So there's hoops to jump through with the sexual decision making.

[700] I looked at the main thing I looked at was this model of I applied delayed discounting to what we talked about earlier than now versus later that kind of decision making that goes along with addiction.

[701] I applied that to condom use decisions and I've done probably published about 20 or so papers with this and different drugs.

[702] And so the The primary metric is whether you do or don't use a condom, that's the...

[703] Right.

[704] All hypothetical, and so this is using hypothetical decision making, but I've published some studies looking at, showing a tight correspondence to self -reported in correlational studies to self -reported behavior.

[705] So this is like, so, like, how do you, did you do a questionnaire kind of thing?

[706] Right.

[707] So it's a, it's not quite a questionnaire, but it's a, it's a behavioral task requiring that.

[708] them to respond to see you show pictures of a bunch of individuals and it's it's kind of like one of these fun behavioral like a lot of them you get like numbers are boring but it's like okay hot or not like which of these 60 people would you have a one night stand with men women so pick whatever you like a little bit of this a little bit of that whatever you're into it's all variety there out of that group you pick some subsets of people who do you think is the you know the one you most want to have sex with the least he thinks most likely to have an sTI or least likely a sexually transmitted disease by STI and then you could do certain decision making questions so what I've done is asked say this person you read a vignette this person wants to have sex with you now you've met them to get along um casual sex scenario like a one -night stand with a condom's available just rate your likelihood from one to 100 on this kind of scale would you use it would you use but then you can change your your scenario to say okay now imagine you have to wait five minutes to use a condom so the the choice is now instead of using condom versus not in terms of of your likelihood scale, now it ranges from have sex now without a condom versus on the other end of the scale is wait five minutes to have sex with a condom.

[709] So you rate your likelihood of where your behavior would be along that continuum.

[710] And then you could say, okay, well, what about an hour?

[711] What about three hours?

[712] What about, you know, what about 24 hours?

[713] Right.

[714] I'm misunderstanding.

[715] Now without a condom or five minutes later with a condom.

[716] Right.

[717] So what?

[718] So what?

[719] What?

[720] What's supposed to be the preference for the person?

[721] Like, is, like, what, there's a lot of factors coming into play, right?

[722] There's, like, there's, like, pleasure and personal preference, and then there's also the safety.

[723] Those are those competing objectives?

[724] Right.

[725] And so we do get at that through some individual measures, and this task is more of a face -valid task where there's a lot underneath the hood.

[726] So for most people, sex with the condom is the better reward.

[727] But underneath the hood of that is just at the purely physical level, they'd rather have sex without the condom.

[728] It's going to feel better.

[729] What do you mean by reward?

[730] Like, when they calculate their trajectory through life and try to optimize it, then sex with the condom is a good idea?

[731] Well, it's really based on, I mean, yeah, yeah, presumably that's the case that there's, but it's measured by like what would really that first question where there is no delay most people say they would be at the higher and at scale a lot of times 100 % they would said they would definitely use a condom not everybody and that we know that's the case see it's like that that some people don't like com some people say yeah i i want to use a condom but you know quarter of the time ended up not because i guess getting lost in the passion in the moment so for the people i mean the only reason that people so behaviorally speaking at least for a large number of people in many circumstances condom use as a reinforcer just because people do it like you know why are they doing it they're not because it makes the sex feel better but because it makes that it allows for at least the same general reward even if actually even if it feels a little bit not as good yeah you know with the condom nonetheless they get most of the benefit without the concurrent oh my gosh there's this risk of either unwanted pregnancy or getting HIV or way more likely than HIV, you know, herpes, you know, in general awards, et cetera, all the, all the lovely ones.

[732] And we've actually done research saying, like, where we gauge the probability of these individual, different SDIs, and it's like, what's the heavy hitter in terms of what people are using to judge, you know, to evaluate whether they're going to use a condom.

[733] So that's why the condom use is the delayed thing, five minutes or more.

[734] And then, yeah, because that's the first.

[735] Which would normally be the larger later reward, like the $10 versus the nine.

[736] the 10, which is counterintuitive if you just think about the physical pleasure.

[737] So that's a good, that's a good thing to measure.

[738] So Kahnem uses a really good concrete quantitable, quantifiable thing that you can use in a study, and then you can add a lot of different elements like the presence of cocaine and so on.

[739] Yeah, you can get people loaded on like any number of drugs like cocaine, alcohol, and methamphetamine are the three that I've done and published on.

[740] And it's interesting that these are fun studies, man. Right.

[741] I love to get people loaded in a safe context and like, but to really, it started, like, there was some early research with alcohol.

[742] I mean, the psychedelics are the most interesting, but it's like all of these drugs are fascinating.

[743] The fact that all these are keys that unlock a certain, like, psychological experience in the head.

[744] And so there was this work with alcohol that showed that it didn't affect those monetary delay discounting decisions, you know, $9 now versus $10 later.

[745] And I'm like getting people drunk.

[746] And I thought to myself, are you telling me?

[747] that you know getting someone that people being drunk does not cause people at least sometimes to make to choose what's good for them in the short term at the expense of what's good for them in the long term it's like you know bullshit you know like yeah we see like but in what context does that happen so that's what that's something that inspired me to go in this direction of like aha risky sexual decisions is something they do when they're drunk they don't necessarily go home and and even though some people have gambling problems and alcohol interacts with that.

[748] The most typical thing is not for people to go home, log on and change their allocation in their retirement account or something like that.

[749] But they're more likely risky sexual decisions.

[750] They're more likely to not wait the five minutes for the condom and instead go no condom now.

[751] Right.

[752] That's a big effect and we see that.

[753] And interestingly, we do not see with those different drugs, we don't see an effect if we just look at that zero delay condition.

[754] In other words, the condoms right there waiting to be used, would you, how likely are to use it?

[755] You don't see it.

[756] I mean, people are by and large going to use the condom.

[757] Yeah.

[758] So, and that's the way most of this research outside of behavioral economics that just looked at condom use decisions, very little of which has ever actually administered the drugs, which is another unique aspect.

[759] But they usually just look at like assuming the condom is there.

[760] But this is more using behavioral economics to delve in and model something that, and I've done survey research on this, modeling what actually happens like you meet someone at a laundromat like you weren't planning on like you know it's like one thing leads another they live around the corner you know yeah these things you know and like we did one um survey with with men who have sex with men and found that uh 25 % of them 24 % about a quarter reported in the last six months that they had unprotected anal intercourse which is the most risky in terms of sexually transmitted infection in the last six months in a situation where they would have used a condom, but they simply didn't use one just because they didn't have one on them.

[761] So this to me, it's like, unless we delve into this and understand this, these suboptimal conditions, we're not going to fully address the problem.

[762] There's plenty of people that say, yep, condom use is good.

[763] I use it a lot of the time.

[764] You know, it's like, where is that failing?

[765] and it's under these suboptimal conditions, which in Frank, if you think about it, it's like most of the case.

[766] Action is unfolding.

[767] Things are getting hot and heavy.

[768] Someone's like, do you got a condom?

[769] Eh, no. It's like, do they break the action and take 10 minutes to go to the convenience store or whatever?

[770] Maybe everything's closed.

[771] Maybe they've got to wait till tomorrow.

[772] And though there's something to be studied there on the, that just seems like an unfortunate set of circumstances.

[773] Like, what's the solution to that?

[774] is, I mean, what's the psychology that needs to be, like, taken apart there?

[775] Because it just seems like that's the way of life.

[776] We don't expect the things to happen.

[777] Are we supposed to expect them better to be, like, be self -aware enough about our calculations?

[778] Or you see the 10 -minute detour to a convenience store as a kind of thing that we need to understand.

[779] how we humans evaluate the cost of that.

[780] I think in terms of how we use this to help people, it's mostly on the environment side rather than on the...

[781] Indivisial side, you're cool.

[782] Yeah, although those interact, so it's like, you know, in one sense, if you're especially if you're going to be drinking or using another substance that is associated with, you know, a stimulant, alcohol and stimulants go along with risky sex.

[783] You know, good to be aware that you might make decisions just to tell yourself if you might make a decision that that is going to that you wouldn't have made in your sober state.

[784] And so, hey, throwing a condom in the purse and the pocket, you know, might be, you know, a good idea.

[785] I think at the environmental level, just more condom of it.

[786] I mean, it highlights what we know about just making condoms widely available.

[787] Something that I'd like to do is like, you know, reinforcing condom use, you know, so, you know, just getting people used to carrying a condom everywhere they go.

[788] Because it's such a once it's in someone's habit, if they are, say, like a young single person and, you know, it's, you know, they occasionally have unprotected sex, like training those people.

[789] Like, what if you got a text message, you know, once every few days saying, ah, if you, if you show me, send back a photo of a condom within a minute, you get a reward of $5.

[790] You could shape that up like that it's a process called contingency management.

[791] It's basically just straight up operant reinforcement.

[792] You could shape that up with no problem.

[793] And, and, I mean, those procedures of contingency management giving people systematic rewards is like for example the most powerful way to to reduce cocaine use and addicted people and um uh is what but but by saying if you show me a negative urine for cocaine i'm going to give you a monetary reward and like that has huge effects in terms of decreasing cocaine use if that can be that powerful for something like stopping cocaine use how powerful for that could that be for shaping up just carrying a condom because the primary, unlike cocaine use, here, we're not saying you can't have the main reward.

[794] Like, you can still have sex.

[795] And you can even have sex in the way that you tell yourself you'd rather do it, you know, if a condom is available.

[796] You know, so, you know, like, you're not, you know, it's relatively speaking, it's way easier than, like, not using cocaine if you like using cocaine.

[797] It's just basically getting in the habit of carrying a condom.

[798] So that's just one idea of, like, There could be also the capitalistic solutions of like there could be a business opportunity for like a door dash for condoms.

[799] Oh, yeah.

[800] Like delivery.

[801] I thought about this.

[802] Within five minute delivery of a condom at any location, like Uber for condoms.

[803] I've thought about it, not with condoms, but a very similar line of thinking, a line that you're going into in terms of Uber and people getting drunk when they intend to, they end up having one or two.

[804] They ended up having five or six.

[805] and it's like, okay, yeah, you can take the cab home, the Uber home, but you've left your car there, it might get towed, you might, like, there's also the hassle of just, you know, you want to wake up tomorrow with your hangover and forget about it and move on.

[806] Like, and I think a lot of people in their situation, and they're like, screw it, I'm going to take the risk, just get it, you know, what if you had an Uber service where two, you know, you have a, a, a car come out with two drivers.

[807] and um one of them two sober drivers obviously and they and and the person they the one driver drops off the other that then drives you home in their car in your car yeah so that you can i mean i think a lot of people would pay 50 bucks it's going to be more than a regular uber yeah but it's like it's going to be done i got the money i already i already spent 60 bucks at the bar tonight like just get the damn thing done tomorrow i'm done with it my car i wake up my car's in front of my house i think that would be i think someone could i'm not going to open that business so like if anyone hears this and wants to take off with that like i think it could help a lot of people yeah definitely an uber itself i would say helped a huge amount of people just making it easy to make the decision of going home uh not driving yourself i read about in austin where they i don't know where it's at now or were they outlawed uber for a while you know because of the whole taxi cab union type thing and and how just yeah there were like hordes of drunk people that were used to uber that now didn't have a cheap alternative so just uh we didn't exactly mention you've done a lot of studies in sexual decision making with different drugs is there some interesting insights or findings on the difference between the different drugs so i think you said meth as well so cocaine is there some interesting characteristics about decision making that these drugs alter versus like alcohol all those kinds of things i think and there's much more to study with this but i think the biggie there is that the stimulants they create risky sex by really increasing the rewarding value of sex like if you talk to people that are real especially that have are hooked on stimulants one of the biggies is like sex on coke or meth is like so much better than sex without and that's a big part of what why they have trouble quitting because it's so tied to their sex life so it's not that your decision making is broken is just that you well you allocate it's a different aspect of their decision yeah on the reward side i think on the alcohol it works more through disinhibition it's like alcohol is really good at at at reducing the ability of a delayed punisher to have an effect on current behavior in other words there's this bad thing that's going to happen tomorrow or a week from now or 20 years from now.

[808] Being drunk is a really good way.

[809] And you see this in like rats making decisions.

[810] A high dose of alcohol makes someone less sensitive to those consequences.

[811] So I think that's the lever that's being hit with alcohol.

[812] And it's the more just increasing the rewarding value of sex by the psychostimulance on that side.

[813] We actually found that it and it was amazing because like hundreds of millions of dollars have been spent by NIH to study the connection between cocaine and HIV.

[814] Like, we ran the first study on my grant that, like, actually just gave people cocaine under double -blind conditions and showed that, like, yeah, when people are on Coke, like, their ratings of sexual desire, even though they're not in a sexual situation, yeah, you've shown them some pictures, but you're just saying they're horny.

[815] Like, you get subjective ratings of, like, how much sexual desire are you feeling right now?

[816] people get horny when they're on stimulants.

[817] And a lot of people say, duh, if they really know these drugs.

[818] But that's a rigorous study that's in the lab that shows, like, there's a plot.

[819] Right, the dose effects of that, the time course of that.

[820] Yeah, it's not just.

[821] Can you please tell me there's a paper with a plot that shows dose versus evaluation of, like, horniness?

[822] Yeah, we didn't say horniness.

[823] We said sexual arousal.

[824] Yeah, basically, yeah.

[825] There's a plot.

[826] I'm going to find this plot.

[827] Right, right, I'll send it to you.

[828] There was one headline from some publicity on the work that said, horny cocaine users don't use condoms or something like that.

[829] I wouldn't have put it that way, but like, yeah, that's right on.

[830] I guess that's what it finds.

[831] So you've published a bunch of studies on psychedelics.

[832] Is there some especially favorite, insightful findings from some of these you could talk about.

[833] Maybe favorite studies or just something that pops to mind in terms of both the goals and like the major insights gained and maybe the side little curiosities that you discovered along the way.

[834] Yeah.

[835] I think of the work with like using psilocybin to help people quit smoking.

[836] And we've talked about smoking being such a serious addiction.

[837] And so that what inspired me to get into that was just kind of having like behavioral psychology is my primary lens sort of a this sort of like you know kind of radical empirical basis of I'm really interested in the mystical experience and the all of these reports very interested and but at the same time I'm like okay let's let's get down to some behavior change and something that we can record like quantitatively verify biologically.

[838] So find all kinds of negative behaviors that people practice and see if we can turn those into positive.

[839] Right.

[840] Like really change it, not just people saying, which again is interesting.

[841] I'm not dismissing it, but folks that say, my life has turned around.

[842] I feel this has completely changed me. It's like, yep, that's good.

[843] All right, let's see if we can harness that and test that into something that it's, that's real behavior change.

[844] You know what I mean?

[845] It's quantifiable.

[846] It's like, okay, you've been smoking.

[847] for 30 years, you know, like, that's a real thing.

[848] And you've tried a dozen times, like, seriously to quit and you haven't been able to long term, like, okay.

[849] And if you quit, like, we'll ask you, and I'll believe you, but I don't trust everyone reading the paper to believe you.

[850] So we're going to have you pee in a cup and we'll test that.

[851] We'll have you blow into this little machine that measures carbon monoxide, and we'll test that.

[852] So multiple levels of biological verification.

[853] Nice.

[854] Like, now we're getting, like, to me, that's where the rubber meets the road in terms of like therapeutics it's like can we really shift behavior and since in so much as we talked about my other scientific work outside of psychedelics is about understanding addiction and drug use so it's like you know looking at addiction it's a no brainer and smoking is just a great example and so back to your question like we've had really high success rates I mean it really it rivals anything that's been published in the scientific literature the caveat is that you know that's based on our initial trial of only 15 people but extremely high long -term success rates, 80 % at six months per smoke -free.

[855] So can we discuss the details?

[856] So first of all, which psychedelic are we talking about?

[857] And maybe can you talk about the 15 people and how the study ran and what you found?

[858] Yeah, yeah.

[859] So the drug we're using is psilocybin, and we're using moderately high and high doses of psilocybin.

[860] And I should say this about most of our work.

[861] These are not kind of museum -level doses.

[862] In other words, nothing, even big fans of psychedelics want to take and go to a concert or go to the museum.

[863] If someone's at Burning Man on this type of dose, like, they're probably going to want to find their way back to their tent and zip up and hunker down for, you know, not be around strangers.

[864] And by the way, the delivery method, so psilocybin is mushrooms, I guess.

[865] What's the usual?

[866] Is it edible?

[867] Is there some other way?

[868] Like, how are people supposed to think about the correct dosing of these things?

[869] Because I've heard that it's hard to dose correctly.

[870] That's right.

[871] So in our studies, we use the pure compound psilocybin.

[872] So it's a single molecule, you know, a bunch of molecules.

[873] And we give them a capsule with that in it.

[874] And so it's just, you know, a little capsule they swallow.

[875] What people, when psilocybin is used, outside of research it's always in the context of mushrooms because they're so easy to grow there's no market for synthetic psilocybin there's no reason for that to pop up that the the the the the high dose that we use in research is 30 milligrams body weight adjusted so if you're a heavier person it might be like 40 or even 50 milligrams we have some data that based on that data we We're actually moving into, like, getting away from the body weight adjusting of the dose and just giving an absolute dose.

[876] It seems like there's no justification for the body weight -based dosing, but I digress.

[877] Generally, 30, 40 milligrams, it's a high dose.

[878] And based on average, even though, as you alluded to, there's variability, which gets people into some trouble in terms of mushrooms, like Selassi, Cubensis, which is the most common species in the illicit market in the U .S., this is about equivalent to five dried grams, which is right at about where, right where McKenna and others, they call it a heroic dose.

[879] You know, this is not hanging out with your friends, going to the concert again.

[880] So this is a real deal dose, even to people that, like, really, you know, just even to psychonauts.

[881] And even, we've even had a number of studies.

[882] Psychonauts.

[883] Yeah, people that, yeah, that's a great term.

[884] You know, like, for psychedelics.

[885] Yeah, going as far out as possible.

[886] But even for them, even for, even for those who've flown to space before.

[887] Right, right.

[888] They're like, holy shit, I didn't know the orbit would be that far out, you know, like.

[889] Or I escaped the orbit.

[890] it.

[891] I was in interplanetary space there.

[892] So these folks, the 15 folks in the study, there's not a question of dose being too low to truly have an impact.

[893] Right, right.

[894] Very, out of hundreds of volunteers over the years, we've only seen a couple of people where there was a mild effect of the 30 milligrams.

[895] And who knows, that person's their serotonins, they might have lesser density of serotonin two -a receptors or something.

[896] We don't know.

[897] But it's extremely rare.

[898] For most people, this is like something interesting is going to happen, put it that way.

[899] You know, Joe Rogan, I think that Jamie, his producer, is immune to a second.

[900] So maybe he's a good recruit for the state to test.

[901] So that's interesting.

[902] Now, I'm not the caveat is I'm not encouraging anything illicit, but just theoretically, my first question as a behavioral pharmacologist is like, you know, increase the dose.

[903] like really nobody's immune i'm not telling him jamey to do that but like okay like you know you're taking the same amount that friends might be taken but yeah but he was also referring to the psychedelic effects of edible marijuana which is is there is there uh rules on uh dosage for um uh marijuana is there limits like what place where it's this is this all goes it probably is state by state right It is, but most, they've gone that direction and states that didn't initially have these rules have now have them.

[904] So it was like, you'll get, I think, you know, five, 10, I think 10, five or 10 milligrams of THC being a common.

[905] And, and like, and this is an important thing, like, where they've moved from not being allowed to say, like, have a whole candy bar and have each of the eight or 10 squares on the candor bar being 10 milligrams.

[906] But it's like, no, the whole thing.

[907] Because, like, you know, someone gets a candy bar.

[908] They're eating the freaking candy bar.

[909] And it's like if you, unless you're a daily cannabis user, if you take, you know, 100 milligrams, it's like, that's what could lead to a bad trip.

[910] Yeah.

[911] For someone.

[912] And it's like, you know, a lot of these people, it's like, oh, you used to smoke a little weed in college.

[913] They might say they're visiting Denver for a business trip.

[914] And they're like, why not?

[915] Let's give it a shot, you know.

[916] And they're like, oh, I don't want to smoke something because it's going to be.

[917] So I'm going to be safer with this edible.

[918] They like consume this massive, you know.

[919] But there's huge tolerance.

[920] And so a regular, like for someone who's smoking weed every day, they might take five milligrams and kind of hardly feel anything.

[921] And they may really need something like 30, 40, 50 milligrams that have a strong effect.

[922] But yeah, so they've evolved in terms of the rules about like, okay, what constitutes a dose, you know, which is why you see less big candy bars and more.

[923] Or if it is, if it is a whole candy bar, you're only getting a smaller dose like 10 milligrams or, yeah.

[924] Yeah, because that's where people get in trouble more often with edibles.

[925] Yeah, except Joey Diaz, which I've heard.

[926] That's definitely somebody I want to talk to.

[927] Out of the crazy comedians, I want to talk to as well.

[928] Anyway, so, yeah, the study of the 15 and the dose not being a question.

[929] So, like, what was the recruitment based on, what was the, like, how did the study get conducted?

[930] Yeah, so the recruitment, and I really liked this fact, it wasn't people that, you know, largely were, you know, we were honest about what we were studying, but for most people, it was, they were in the category of, like, you know, not particularly interested in psychedelics, but more of like, they want to quit smoking.

[931] They've tried everything, but the kitchen sink.

[932] Yeah.

[933] And this sounds like the kitchen sink.

[934] it's like well it's hopkins so you know thinking that sounds like it's safe enough so like what the hell let's give it a shot like most of them were in that category which i really you know i i appreciate because it's more of a of a test you know of of yeah just like a better model of what if these are approved as medicines like what you're going to have the average participant you know, be like.

[935] And so the therapy involves a good amount of non -silocybin sessions, so preparatory sessions, like eight hours of getting to know the person, like the two people who are going to be their guides or the person in the room with them during the experience, having these discussions with them where you're both kind of rapport building, just kind of discussing their life, getting to know them, but then also telling them, preparing them about the psilocybin experience, So it could be scary in this sense, by what, here's how to handle it, trust let go be open.

[936] And also during that preparation time, preparing them to quit smoking, using really standard bread and butter techniques that can all fall under the label, typically of the cognitive behavioral therapy, just stuff like before you quit, we assign a target quit date ahead of time.

[937] You're not just quitting on the fly.

[938] And that happens to be the target quit date in our study was the day where they got the first psilocybin dose.

[939] But doing things like keeping a smoking diary like okay during the three weeks until you quit every time you smoke a cigarette just like jot down what you're doing what you're feeling what situation that type of thing and then having some discussion around that and then going over the pluses and minuses in their life that smoking kind of comes with and being honest about the this is what it does for me this is why i like it this is why i don't like it preparing for like what if you what if you do slip how to handle it like don't dwell in guilt because that leads to more full on relapse you know just kind of treat it as a learning experience that type of thing then you have the session day where they come in they they um five minutes of questionnaires but pretty much they jump into the we we touch base with them and they we we give them the capsule it's a serious setting but you know a comfortable one they're in a room that looks more like a living room than like a research lab we measure their blood pressure than any experience but kind of minimal kind of medical vibe to it and um they lay down on a couch and it's a purposefully an introspective experience.

[940] So they're laying on a couch during most of the five to six hour experience and they're wearing eyeshades, which is a better connotation as a name than blindfold.

[941] So they're wearing eye shades, and they're wearing headphones through which music is played.

[942] Mostly classical, although we've done some variation of that.

[943] I have a paper that was recently accepted kind of comparing it to more like gongs and harmonic bowls and that type of thing kind of like sound you know kind of um you you've uh you've also added this to the science and have a paper on the musical accompaniment to the psychedelic experience is fascinating right and we found basically that the about the same effect even by a trend not significant but a little bit better of an effect both in terms of um subjective experience and long term whether it helped people quit smoking just a little tiny non -significant trend even favoring the the novel playlist with the the Tibetan singing bowls and the gongs and all did you do and all of that and so anyway just saying okay we can deviate a little bit from this like what goes back to the 1950s of this method of using classical music as part of this psychedelic therapy but they're listening to the music and they're not playing DJ in real time you know it's like you know they're just be the baby you're not the decision maker for today go inward trust let go be open and pretty much the only interaction like that we're there for is to deal with any anxiety that comes up so guide is kind of a misnomer and a sense sense, it's, we're a more of a safety net.

[944] And so, like, tell us if you feel some butterflies that we can provide reassurance.

[945] A hold of their hand can be very powerful.

[946] I've had people tell me that that was, like, the thing that really just grounded them.

[947] Can you break apart trust, let go, be open?

[948] What, uh, what?

[949] So, in a sense, how would you describe the experience, the intellectual and the emotional approach that people are supposed to take to really let go into the experience.

[950] Yeah, so trust is, trust the context, you know, trust the guides, trust the overall, in institutional context.

[951] I see it as layers of, like, safety, even though it's everything I told you about the relative bodily safety of psilocyb.

[952] Nonetheless, we're still getting blood pressure throughout the session just in.

[953] case.

[954] We have a physician on hand who can respond just in case.

[955] We're literally across the street from the emergency department, just in case, you know, all of that, you know.

[956] Privacy is another thing you've talked about, is just trusting that you're, whatever happens is just between you and the people in the study.

[957] Right.

[958] And hopefully they've really gotten that by that point deep into the study that, like, they realize we take that seriously and everything else, you know.

[959] And so it's really kind of like a very special role you're playing as a, as a researcher or a guide, and and hopefully they have your trust.

[960] And so, you know, and trust that they could be as emotional, everything from laughter to tears, like that's going to be welcomed.

[961] We're not judging them.

[962] It's like, it's a therapeutic relationship where, you know, this is a safe container.

[963] It's a safe space.

[964] Safe space.

[965] That has a lot of baggage to that term.

[966] But it truly is.

[967] It's a safe space for that, for this type of experience and to let go.

[968] So trust, let's see, let go.

[969] So that relates to the emotional, like, you feel like crying, cry.

[970] I feel like laughing your ass off, laugh your ass off, you know, it's like all the things actually that sometimes it's more challenging with a recreate, someone has a large recreational use.

[971] Sometimes it's harder for them because people in that context, and understandably so, it's more about holding your shit.

[972] Yeah.

[973] Someone's had a bunch of mushrooms at a party.

[974] Maybe they don't want to go into the back room and start crying about these thoughts about the relationship with their mother.

[975] and they don't want to be the drama queen or king that bring their friends down because their friends are having an experience too and so they want to like compose you know and also just the appearance in social settings versus the so like prioritizing how you appear to others versus the prioritizing the depth of the experience and here in the study you can prioritize the experience right and it's all about like you're the astronaut and there's only one astronaut we're ground control and I use this all often with um that's good i have a photo of the space shuttle on a plaque in my in my office and i kind of use often use that as example it's like we're here for you like we're a team but we have different roles it's just like you don't have to like compose yourself like you don't have to like be concerned about our safety like we're playing these roles today and like yeah your job is to go as deep as possible or as far out whatever your analogy is like as possible and and we're keeping you you safe And so, yeah, and you really, the emotional side is a hard one, you know, because you really want people to, like, if they go into realms of subjectively of despair and sorrow, like, yeah, like cry, you know, like, it's okay, you know, and especially if someone's, you know, more macho and, you know, you want this to be the place where they, they can let go.

[976] And, and again, something that they wouldn't or shouldn't do if someone was to theoretically use it in a, in a social.

[977] setting and like and also these other things like even that you get in those so social settings of like yeah you don't have to like worry about your wallet for being taken advantage or for a woman sexually assaulted by some creep at a concert or something because they're you know they're laying down being far out there's like a million sources of anxiety they're external versus internal so you just focus on your own like right the beautiful thing that's going on in your mind and even the cops at that layer even though it's extremely unlikely for most people that cops would come in and bust them right when like even at that theoretical like that one in a billion chance like that might be a real thing psychologically in this context we even got that covered this is we've got DEA approval yeah like you are this is okay by every level of society yeah that counts you know that has the authority so it's so go deep trust the you know trust the setting trust yourself um you know let go and be open so in the experience And this is all subjective and by analogy, but like, if there's a door, open it, go into it.

[978] If there's a stairwell, go down it or a stairway, go up it.

[979] If there's a monster in the mind's eye, you know, don't run, approach it, look in the eye and say, you know, let's talk.

[980] Yeah, what's up?

[981] What are you doing here?

[982] Let's talk turkey, you know.

[983] And I thought - Right.

[984] It really is that.

[985] That really is a heart of it, this radical courage.

[986] Like it, courage.

[987] People are often struck by that coming out.

[988] Like, this is heavy lifting.

[989] This is hard work.

[990] People come out of this exhausted.

[991] And it's, it can be extremely, some people say it's the most difficult thing they've done in their life.

[992] Like choosing to let go on a moment, a microsecond by microsecond basis.

[993] Everything in their inclination is to is to say stop, sometimes stop this.

[994] I don't like this.

[995] I didn't know it was going to be like this.

[996] This is too much.

[997] And Terrence McKenna put it this way.

[998] It's like comparing to meditation and other techniques, it's like spending years, trying to press the accelerator to make something happen.

[999] Heido's psychedelics is like you're speeding down the mountain in a fully loaded semi -truck and you're charged with not slaming the brake.

[1000] It's like, you know, let it happen.

[1001] You know, so it's very difficult and to engage, always, you know, go further into.

[1002] to it and take that radical, you know, radical courage, you know, throughout.

[1003] What do they say in self -report, if you can put general words to it, what is their experience like?

[1004] What do they say it's like?

[1005] Because these are many people, like you said, that haven't probably read much about psychedelics or they don't have, like, with Joe Rogan, like language or stories to put on it.

[1006] So this is very raw self -report of experiences.

[1007] What do they say the experiences like yeah and some more so than others because everyone has been exposed at some level or another but some it is pretty superficial as you're as you're saying um one of the hallmarks of psychedelics is just their variability so i'm more stress it's like not the mean but the standard deviation is so wide that it's like it could be like hellish experiences and and you know um just absolutely beautiful and loving experiences everything that's in between and and both of those like those could be two minutes apart from each other yeah and sometimes kind of at the same at the same time concurrently so let's see there's different ways to there were some Jungian a psychologist back in the 60s masters in Houston that wrote a really good book the varieties of psychedelic experience kind of which is a play on varieties of religious experience by William James that they described this a perceptual level So most people have that, you know, when, you know, whether they're looking at the room without the eye shades on or inside their, their mind's eye with the eye shades on, colors, you know, sounds like this as a much richer, um, censorium, you know, which can be very interesting.

[1008] And then at another level, a master's in Houston called at the psychodynamic level.

[1009] And I think you can think about it more broadly than that, you know, that's kind of union.

[1010] But just the personal psychological level.

[1011] is how I think of it.

[1012] Like, this is about your life.

[1013] There's a whole life review.

[1014] Oftentimes people have thoughts about their childhood, about their relationships, their spouse or partner, their children, their parents, their family of origin, their current family.

[1015] Like, you know, that stuff comes up a lot, including every, like, like the love, just people just, like, pouring with tears about, like, how much, like, it hits them so hard how much they love people.

[1016] Yeah.

[1017] Like, in a way that, you know, for people that, like, they love their family but like it just hits them so hard that like how important this is and like the magnitude of that love and like what that means in their life so those those are some of the most moving experiences to be present for is where people like it hits home like what really matters in their life and and then you have this sort of what masters in houston called the archetypal realm which again is sort of viewing in with the focus on archetypes which is interesting but I think of that more generally is like symbolic level so just really deep experiences where you have you do have experiences that seem symbolic of you know very much in like you know what we know about dreaming and what most people think about dreaming like there's this randomness of things but sometimes it's pretty clear in retrospect oh like this came up because this thing has been on my mind you know recently so it seems to be there seems to be this symbolic level and then they have this the last level that they describe is the mystical integral level which and this is where there's lots of terms for it but transcendental experiences experiences of unity mystical type effects we often measure on europeans use a scale that will refer to oceanic boundlessness this is all pretty much the same thing yeah this is like at some sense the deepest level of the very sense of self seems to be dissolved, minimize, or expand it such that the boundaries of the self go into and here, I think some of this is just semantics, but whether the self is expanding such that there's no boundary between the self and the rest of the universe or whether there's no sense of self, again, might be just semantics, but this radical shift or sense of loss of sense of self or self boundaries.

[1018] And that's like the most, typically when people have that experience, they'll often report that as being the most remarkable thing.

[1019] And this is which you don't typically get with MDMA.

[1020] These deepest levels of the nature of reality itself, the subjectivity and objectivity just like the seer and the scene become one.

[1021] And it's a process.

[1022] And yeah.

[1023] And they're able to bring that experience back and be able to describe it?

[1024] yeah but but one of the to a degree but one of the hallmarks going back to William James of describing a mystical experience is the ineffability and so even though it's ineffable people try as far as they can to describe it when you get the real deal they'll say and even say that though they say a lot of helpful things to help you describe the landscape they'll say no matter what I say I'm still not even coming anywhere close to what this was like the language is completely failing and I like to joke that even though it's It's ineffable, and we're researchers, so we try to eff it up by asking them to describe the experience.

[1025] I love it.

[1026] Yeah.

[1027] It's a good one.

[1028] But to bring it back a little bit, so for that particular study on tobacco, what was the results?

[1029] What was the conclusions in terms of the impact of psilocybin on their addiction?

[1030] So when that pilot study was very, it was very small and it wasn't a randomized study, so it was limited.

[1031] The only question we could really answer was, is this worthy enough of follow -up?

[1032] Yes.

[1033] And the answer to that was Apsa Freakantly, because the success rates were so high, 80 % biologically confirmed successful at six months.

[1034] That held up to 60 % biologically confirmed abstinent at an average of two and a half years, a very long fall.

[1035] Yeah.

[1036] And so, I mean, the best that's been reported in the literature for smoking cessation is in the upper 50%, and that's with not one but two medications for a couple of months, followed by regular.

[1037] cognitive behavioral therapy where you're coming in once a week or once every few weeks for an entire year.

[1038] And so, but this is like very heavy.

[1039] And this is just like a few uses of psilocybin.

[1040] So this was three doses of psilocybin over a total course, including preparation, everything, a 15 week period where there's mainly like, for most part, one one meeting a week, and then the three sessions are within that.

[1041] And so it's, and we scale that back in the more, The study we're doing right now, which I can tell you about, which is a randomized controlled trial, but it's the, yeah, the original, you know, pilot study was, you know, these 15 people.

[1042] So given the, like, the positive signal from the first study telling us that it was a worthy pursuit, we hustled up some money to actually be able to afford a larger trial.

[1043] So it's randomizing 80 people to get either one psilocybin session when we've narrowed, we've scaled that down from three to one, mainly because we're doing fMRI neuroimaging before and after.

[1044] And it made it more experimentally complex to have multiple sessions.

[1045] But one psilocybin session versus the nicotine patch using the FDA approved label, like standard use of the nicotine patch.

[1046] So it's randomized.

[1047] 40 people get randomized to psilocybin, one session.

[1048] 40 people get nicotine patch, and they all get the same cognitive behavioral therapies for the standard talk therapy.

[1049] And we've scaled it down somewhat, so there's less weekly meetings, but it's been within the same ballpark.

[1050] And right now, we're still, the study still ongoing.

[1051] And in fact, we just recently started recruiting again.

[1052] We paused for COVID.

[1053] Now we're starting back up with some protections like masks and whatnot.

[1054] But right now for the 44 people.

[1055] who have gotten through the one -year follow -up, and so that includes 22 from each of the two groups.

[1056] The success rates are extremely high.

[1057] For the psilocybin group, it's 59 % have been biologically confirmed as smoke -free at one year after their quit date.

[1058] And that compares to 27 % for the nicotine patch, which, by the way, is extremely good for the nicotine patch compared to previous research.

[1059] So the results could change because it's ongoing, but we're mostly done and it's still looking extremely positive so if anyone's interested they have to be sort of be in commuting distance to the Baltimore area but you know to participate right right to participate this is a good moment to bring up something I think a lot of what you talked about is super interesting and I think a lot of people listening to this so now it's anywhere from 300 to 600 ,000 people for just a regular podcast, I know a lot of them will be very interested in what you're saying, and they're going to look you up, and they're going to find your email, and they're going to write you a long email about some of the interesting things I've found in any of your papers.

[1060] How should people contact you?

[1061] What is the best way for that?

[1062] Would you recommend?

[1063] You're a super busy guy.

[1064] You have a million things going on.

[1065] How should people communicate with you?

[1066] thanks for bringing this up this is a i'm glad to get the opportunity to address this if someone's interested in participating in a study yes the best thing to do is go to the website of the study or of uh like yeah which website so we have all of our psilocybin study so everything we have is up on one website and then we link to the different study websites but hopkins psychedelic dot org so everything we do or if you don't remember that, just, you know, go to your favorite search engine and look up Johns Hopkins Psychedelic, the U .S., you can look at clinical trials .gov and look up the term psilocybin.

[1067] And in fact, optionally, people even in Europe can register their trial on there.

[1068] So that's a good way to find studies.

[1069] But for our research, rather than emailing me, a more efficient way is to go straight.

[1070] And you can do that first, the first phase of screening, there's some questions online, and then someone will get back in touch with you.

[1071] but I do already you know and I you know I expect it's like going to increase but I'm already at the level where my simple limited mind and limited capacity is already I sometimes fail to get back to emails I mean I'm trying to respond to my colleagues my mentees all these things my responsibilities and as many of the people just inquiring about I want to go to graduate school I'm interested in this I had this I have a daughter that took a second duck and she's having trouble and it's like I try to respond to those but sometimes I just simply can't get to all of those already.

[1072] To be honest, like from my perspective, it's been quite heartbreaking because I basically don't respond to any emails anymore.

[1073] And especially you mentioned mentees and so on, like outside of that circle, it's heartbreaking to me how many brilliant people that are thoughtful people, like loving people, and they write long emails that are really, by the way, I do read them very often.

[1074] It's just that I don't, the response is then you're starting a conversation.

[1075] And there's, the heartbreaking aspect is you'll only have so many hours in the day to have deep meaningful conversations with human beings on this earth.

[1076] And so you have to select who they are, and usually it's your family, it's people like you're directly working with.

[1077] And even, I guarantee you, with this conversation, people will write you long, very thoughtful emails.

[1078] Like, there'll be brilliant people, faculty from all over, PhD students from all over.

[1079] And it's heartbreaking because you can't really get back to them.

[1080] But you're saying, like, many of them, if you do respond, it's more like, here, go to this website.

[1081] If you're, for when you're interested into the study, it makes sense to directly go to the site if there's applications open, just apply for the study.

[1082] Right, right, right.

[1083] You know, as either a volunteer or if we're looking for, you know, somebody, you know, we're going to be, you know, posting, including on the Hopkins University website, we're going to be posting if we're looking for a position.

[1084] I am right now actually looking through and it's mainly been through email and contacts, but should I say it?

[1085] I think I'd rather cast my answer, but I'm looking for a postdoc right now.

[1086] Oh, great.

[1087] Um, so I've mentored postdocs for, I don't know, like a dozen years or so and more and more of their time is being spent on psychedelic.

[1088] So someone's free to contact me. That's more of a, that's sort of so close to home.

[1089] That's a personal, you know, that like emailing me about that.

[1090] But I come to appreciate more the advice that folks like Tim Ferriss have of like, I think it's him like five sends emails, you know, like, you know, a subject that gets to the point that totally.

[1091] you what it's about so that like you break through the signal to the noise but i really appreciate what you're saying because part of the equation for me is like i have a three -year -old and like my time on the ground on the floor playing blocks or cars with him is part of that equation and even if the day is ending and i know some of those emails are slipping by and i'll never get back to them and i have i'm struggling with it i'm already and i get what you're saying is i haven't seen anything yet if with the type of exposure that like your podcast this will bring an exposure and then I think in terms of postdocs, this is a really good podcast in the sense that there's a lot of brilliant PhD students out there that are looking for poster from all over from MIT, probably from Hopkins.

[1092] This is just all over the place.

[1093] So this is, and I, we have different preferences, but my preference would also be to have like a form that they could fill out for post, because, you know, it's very difficult through email to tell who's a really going to be a strong collaborator for you, like a strong post.

[1094] stock, strong student, because you want a bunch of details, but at the same time you don't want a million pages worth of email.

[1095] So you want a little bit of application process.

[1096] So usually you set up a form that helps me indicate how passionate the person is, how willingly they are to do hard work.

[1097] Like, I often ask a question, people, of what do you think is more important to work hard or to work smart, and I use that, those types of questions to indicate who I would like to work with because it's counterintuitive.

[1098] But anyway, I'll leave that question unanswered for people to figure out themselves.

[1099] But maybe if you know my love for David Goggins, you will understand.

[1100] So anyway.

[1101] Those are good thoughts about the forms and everything.

[1102] It's difficult.

[1103] And that's something that evolves email email is such a messy thing there's uh speaking of baltimore cal newport if you know who that is um he wrote a book called deep work he's a computer science professor and he's currently working on a book about email about all the ways that email is broken so it's just this is going to be a fascinating read this is a little bit of a general question but uh almost a bigger picture question that we touched on a little bit bit, but let's just touch it in a full way, which is what have all the psychedelic studies you've conducted taught you about the human mind, about the human brain and the human mind?

[1104] Is there something, if you look at the human scientist you were before this work and the scientist you are now, how is your understanding of the human mind changed?

[1105] I'm thinking of that in two categories, one kind of more scientific, and they're both scientific, but one more about, you know, more about the brain and behavior and the mind, so to speak, and as a behaviorist, I always see sort of the mind as a metaphor for behaviors, but anyway, that gets philosophical.

[1106] But it's really increasing the, so the one category is increasing the appreciation for the magnitude of depth.

[1107] I mean, so these are all metaphors of human experience that might be a good way to, because you use certain words like consciousness and what, and it's like we're using constructs that aren't well defined unless we kind of dig end.

[1108] but into human experience like that the experiences on these compounds can be so far out there or so deep and that like and they're doing that by tinkering with the same machinery that's going on up there i mean i'm my assumption and i think it's a good assumption is that all experiences you know there's a there's a biological side to all phenomenal experience you know so there there is not You know, the divide between biology, you know, and experience or psychology is, you know, it's not one or the other.

[1109] These are just two, you know, two sides of the same coin.

[1110] I mean, you're avoiding the use of the word consciousness, for example, but the experience is referring to the subjective experience.

[1111] So it's the actual technical use of the word consciousness of, yeah.

[1112] Yeah, have a subjective experience.

[1113] And even that word, there are certain ways that, like, sort of like if we're talking about access consciousness or narrative self -awareness, which is an aspect of, like, you can wrap a definition around that and we can talk meaningfully about it, but so often around psychedelics, it's used in this much more.

[1114] You know, in terms of ultimately explaining phenomenal consciousness itself, the so -called hard problem, you know, relating to that question and psychedelics really haven't spoken to that.

[1115] That's why it's hard because it's hard to imagine anything.

[1116] But I think what I was getting is that psychedelics have done this by the reason I was getting into the biology versus mind, psychology divide, is that just to kind of set up the fact that I think all of our experience is related to these biological events.

[1117] So whether they be naturally occurring neurotransmitters like serotonin and dopamine and noraphenephrin, et cetera, and a whole other sort of biological activity and kind of another layer up that we could talk about as network activity, communication amongst brain areas, like this is always going on, even if I just prompt you to think about a loved one, you know, like there's something happening biologically.

[1118] Okay, so that's always another side of the coin.

[1119] And another way to put that is all of our subjective experience outside of drugs.

[1120] It's all a controlled hallucination in a sense.

[1121] Like this is completely constructed.

[1122] Our experience of reality is completely a simulation.

[1123] So I think we're on solid ground to say that that's our best guess and that's a pretty reasonable thing to say scientifically.

[1124] All the rich complexity of the world emerges from just some biology and some chemicals.

[1125] So in that, you know, and that definition implied a causation, it comes from.

[1126] And so that's, that's what we know at least there's solid correlation there.

[1127] And so then we delve dig in, we delve deep into the philosophy of like idealism or materialism and things like this, which I'm not an expert in, but I know we're getting into that territory.

[1128] You don't even necessarily have to go there, like, you at least go to the level of like, okay, we know there's, there seems to be this one -on -one correspondence.

[1129] And that seems pretty solid.

[1130] Like you can't prove a negative and you can't prove, you know, it's in that category of like, you could come up with an experience that maybe doesn't have a biological correlate, but then you're talking about there's also the limits of the science.

[1131] So is it a false negative.

[1132] But I think our best guess and a very decent assumption is that every psychological event has a biological correlate.

[1133] So with that said, you know, the idea that you can throw, alter that biology in a pretty trivial manner.

[1134] I mean, you could take like a relatively small number of these molecules, throw them into the nervous system, and then have a 60 -year -old person who has, you name it, I mean, that has hiked to the top of Everest and that speaks five languages and that has been married and has kids and grandkids and has, you name it, you know, like, been at the top and say, this fundamentally changed who I am as a. person and the and what i think life is about like that's that's the thing about psychedelics that just floors me and it it never fails i mean sometimes you get bogged down by the paperwork and running studies and all the i don't know all of the the the BS that can come with being in academia and everything and then you and sometimes you get some dud sessions where it's not the full all the magic isn't happening and it's you know more or less it's or it's either a dud or somewhere and i don't mean to dismiss them but you know it's it's not like these magnificent sort of reports but sometimes you get the full monte report from one of these people and you're like oh yeah that's why we're doing this whether it's like therapeutically or just to understand the mind and you're like you're still floored like how is that possible how did we slightly alter serotonergic neurotransmission and say in this person is now saying that they're they're making fundamental differences in the in the priorities of their life after 60 years it also just fills you with awe of the possibility of experiences we're yet to have uncovered if just a few chemicals can change so much it's like man what if this could be opt I mean like how because we're just like took a little it's like lighting a match or something in the darkness and you could see there's a lot more there but you don't know how much more and that's and then like where's that going to go with like I mean I'm always like aware of the fact that like we always as humans and as scientists think that we figured out 99 % and we're working on that first 1 % and we got to keep reminding ourselves it's hard to do like we figured out like not even 1 % like we know nothing and so like I can't I can speculate, and I might sound like a fool, but like what are drugs, even the concept of drugs, like 10 years, 50 years, 100 years, a thousand years if we're surviving, like, you know, molecules that go to a specific area of the brain, in combination with technology, in combination with the magnetic stimulation, in combination with the, you know, like targeted pharmacology of like, oh, like this subset of serotonin 2A receptors in the clostrum, you know, at this time, in this particular sequence in combination with this other thing like this baseball cap you wear that like has you know has one of the is doing some of these things we can only do with these like giant like pieces of equipment now like where it's going to go is going to be endless and it becomes easy to combine within virtual reality where the virtual reality is going to move from being something out here to being more in there and then we're getting like we talked about before we're already in a virtual reality in terms of human perception and cognition models of the of the universe being all representations and you know sort of color not existing and just you know our representations of EM wavelengths etc you know sound being vibrations and all of this and so as the the external VR and the internal VR come closer to each other like this is what I think about in terms of the future of drugs like all of this stuff sort of combines and and like where that goes is just it's it's unthinkable like we we're probably going to you know again I might sound like a fool and this may not happen but I think it's possible you know to go completely offline like where most of people's experiences may be going into these internal worlds and I mean maybe you through through some through a combination of these techniques, you create experiences where someone could live a thousand years in terms of maybe they're living a regular lifespan, but over the next two seconds you're living a thousand years worth of experience.

[1135] Inside your mind.

[1136] Yeah, through this manipulation of the...

[1137] Like, is that possible?

[1138] Like, just based on, like, first principles?

[1139] Yeah, first principles, yes.

[1140] I think so.

[1141] Yeah.

[1142] Like, give us another 50, 500, 500, like, who knows, but, like, how could it not go there?

[1143] In a small tangent, what are your thoughts in this broader definition of drugs, of psychedelics, of mind -altering things?

[1144] What are your thoughts about neuralink and brain computer interfaces, sort of being able to electrically stimulate and read neuronal activity in the brain and then connect that to the computer, which is another way.

[1145] from a computational perspective for me, is kind of appealing, but it's another way of altering subtly the behavior of the brain that's kind of, if you zoom out, reminiscent of the way psychedelics do as well.

[1146] Right.

[1147] So what do you have, like what do you have Thosobal NeurLink?

[1148] What are your hopes as a researcher of mind -altering devices, systems, chemicals?

[1149] I guess broadly speaking, I'm all for it.

[1150] I mean, for the same reason I am with psychedelics, but it comes with all the caveats.

[1151] You know, you're going into a brave new world where it's like all of a sudden there's going to be a dark side.

[1152] There's going to be, you know, serious ethical considerations, but that that should not stop us from moving there.

[1153] I mean, particularly the stuff from an unknown expert, but on the short list in the short term, it's like, yeah, can we help these serious neurological disorders?

[1154] Like, hell yeah.

[1155] Like, and I'm also sensitive to something being someone that has lots of, you know, neuroscience colleagues.

[1156] You know, with some of the stuff, and I can't talk about particulars, I'm not recalling, but, you know, in terms of, you know, stuff getting out there and then kind of a mocking of, of, of, you know, oh, gosh, they're saying this is unique.

[1157] We know this, or sort of like this belittling of like, oh, you know, this sounds like it's just a. I don't know, a commercialization or like an oversimple.

[1158] I forget what the example was, but something like something that came off to some of my neuroscientific colleagues as an oversimplification or at least the way they said it.

[1159] Oh, from a NeurLink perspective.

[1160] Right.

[1161] Oh, we've known that for years.

[1162] Yes, I see.

[1163] But I'm very sympathetic to like, maybe it's because of my very limited, but relatively speaking, the amount of exposure to the psychedelic work has had to my limited experience of being out there.

[1164] and then you think about someone like Mike Musk who's like like really really out there and you just get all these arrows that like and it's hard to be like when you're plowing new ground like you're going to get you're going to criticize like every little word that you like this balance between speaking to like people to make it meaningful something scientists aren't very good at yes having people understand what you're saying and then being belittled by oversimplifying something in terms of the public message so I'm extremely sympathetic And I'm a big fan of what Elon Musk does, like, tunnels through the ground and SpaceX and all of this.

[1165] It's just like, hell yeah, like, this guy has some, he has some great ideas.

[1166] And there's something to be said.

[1167] It's not just the communication to the public.

[1168] I think his first principle is thinking, it's like, because I get this in the artificial intelligence world.

[1169] There's probably similar to neuroscience world where Elon will say something like, or I worked at MIT, I worked on autonomous vehicles.

[1170] And he's sort of, I can sense how much he pisses off, like, every roboticist at MIT and everybody who works on, like, the human factor side of safety of autonomous vehicles in saying, like, we don't need to consider human beings in the car.

[1171] Like, the car will drive itself.

[1172] It's obvious that neural networks is all you need.

[1173] Like, it's obvious that, like, we should be able to, systems that should be able to learn constantly.

[1174] And they don't really need LIDAR.

[1175] They just need cameras because we humans just use our eyes and that's the same as cameras.

[1176] So like it doesn't, why would we need anything else?

[1177] And you just have to make a system that learns faster and faster and faster.

[1178] And neural networks can do that.

[1179] And so that's pissing off every single community.

[1180] It's pissing off human factors community saying you don't need to consider the human driver in the picture.

[1181] You can just focus on the robotics problem.

[1182] It's pissing off every robotics person.

[1183] for saying LIDAR can be just ignored.

[1184] It can be camera.

[1185] Every robotics person knows that camera is really noisy that's really difficult to deal with.

[1186] But he's, and then every AI person who hears neural networks and says like neural networks can learn everything, like almost presuming that it's kind of going to achieve general intelligence.

[1187] The problem with all those haters in the three communities is that they're looking one year, five years ahead, the hilarious thing about the quote -unquote ridiculous things that Elon Musk is saying is they have a pretty good shot of being true in 20 years.

[1188] And so like when you just look at the, you know, when you look at the progression of these kinds of predictions, and sometimes first principles thinking can allow you to do that is you see that it's kind of obvious that things are going to progress this way.

[1189] And if you just remove the prejudice you hold about the particular battles of the current academic environment and just look at the big picture of the progression of the technology, you can usually see the world in the same kind of way.

[1190] And so in that same way looking at psychedelics, you can see like there is so many exciting possibilities here if we fully engage in the research.

[1191] Same thing with NeurRLink.

[1192] if we fully engage, so we go from 1 ,000 channels of communication of the brain to billions of channels of communication of the brain, and we figure out many of the details of how to do that safely with neurosurgery and so on, that the world would just change completely in the same kind of way that Elon is, it's so ridiculous to hear him talk about symbiotic relationship between AI and the human brain, but it's like, is it though like it's is it is it because it's I can see in 50 years that's going to be an obvious like everyone will have like obviously you have like why are we typing stuff in the computer doesn't make any sense that's stupid people used to type on a keyboard with a mouse what is that it seems pretty clear like we're going to be there yeah like and the only question is like what's the time frame is that going to be 20 or is it 50 or 100 like how could we not And the thing that I guess upsets with Elon and others is the timeline he tends to do, I think a lot of people tend to do that kind of thing.

[1193] I definitely do it, which is like it'll be done this year versus like it'll be done in 10 years.

[1194] The timeline is a little bit too rushed.

[1195] But from our leadership perspective, it inspires the engineers to do the best work of their life to really kind of believe.

[1196] Because to do the impossible, you have to first believe it, which is a really important aspect.

[1197] of innovation.

[1198] And there's the delay discounting aspect I talked about before.

[1199] It's like saying, oh, this is going to be a thing 20, 50 years from now.

[1200] It's like what motivates anybody?

[1201] And even if you're fudging it or like wishful thinking a little bit or, let's just say airing on one side of the probability distribution, like there's value in saying like, yeah, like there's a chance we could get this done in a year.

[1202] And you know what?

[1203] And if you set a goal for a year and you're not successful, hey, you might get it done in three years.

[1204] Whereas if you had aimed at 20 years Well, you either would have never done it at all Or you would have aimed at 20 years And then would have taken you 10 So the other thing I think about this Like in terms of his work And I guess we've seen it with psychedelics It's like there's a lack of appreciation For like sort of the variability You need a natural selection Sort of extrapolating from biological You know from evolution like Hey maybe he's wrong about Focusing only on the cameras And not these other things be empirically driven it's like yeah you need to like when he's you know when you need to get the regulation is it safe enough to get this thing on the road those are real questions and be empirically driven and if he can meet the whatever standard is is relevant that's the standard and be driven by that so don't let it affect your ethics but if he's on the wrong path how wonderful someone's exploring that wrong path he's going to figure out it's a wrong path and like other people he's damn it he's doing something yeah like he's you know and and so appreciate that variability, you know, that like it's valuable even if he's not on.

[1205] I mean, this is all over the place in science.

[1206] It's like a good theory.

[1207] One standard definition is that it generates testable hypotheses.

[1208] And like the ultimate model is never going to be the same as reality.

[1209] Some models are going to work better than others.

[1210] Like, you know, Newtonian physics got us a long ways, even if there was a better model like waiting.

[1211] And some models weren't as good as, you you know, we're never that successful, but just even, like, putting them out there and testing.

[1212] We wouldn't know something is a bad model until someone puts it out anyway, so.

[1213] Diversity of ideas is essential for progress, yeah.

[1214] So we brought up consciousness a few times.

[1215] There's several things I want to kind of disentangle there.

[1216] So one, you've recently wrote a paper titled Consciousness, Religion, and Gurus, Pitfalls of Psychedelic Medicine.

[1217] So that's one side of it.

[1218] you've kind of already mentioned that these terms can be a little bit misused or used in a variety of ways that they can be confusing.

[1219] But in a specific way, as much as we can be specific about these things, about the actual hard problem of consciousness or understanding what is consciousness, this weird thing that it feels like, it feels like something to experience things, have psychedelics giving you some kind of insight on what is consciousness?

[1220] You've mentioned that it feels like psychedelics allows you to kind of dismantle your sense of self, like step outside of yourself.

[1221] That feels like somehow playing with this mechanism of consciousness.

[1222] And if it is in fact playing with a mechanism of consciousness using just a few chemicals, it feels like we're very much in the neighborhood of being able to maybe understand the actual biological mechanisms of how consciousness can emerge from the brain.

[1223] So yeah, there's a bunch there.

[1224] I think my preface is that I certainly have opinions that are outside, that I can say, here are my best speculations as a, as just a person.

[1225] and an armchair philosopher, and that philosophy is certainly not my training and my expertise.

[1226] So I have thoughts there, but that I recognize are completely in the realm of speculation that are, like, things that I would love to wrap empirical science around, but that are, you know, there's no data and getting to the hard problem, like no conceivable way, even though I'm very open, like I'm hoping that that problem can be cracked.

[1227] And I do, as an armchair philosopher, I do think that is a problem.

[1228] I don't think it can be dismissed as some people argue it's not even really a problem.

[1229] It strikes me that explaining just the existence of phenomenal consciousness is a problem.

[1230] So anyway, I very much keep that divide in mind when I talk about these things, what we can really say about what we've learned through science, including by psychedelics, versus like what I can speculate on in terms of, you know, the nature of reality and consciousness.

[1231] this.

[1232] But in terms of by and large, skeptically, I have to say, psychedelics have not really taught us anything about the nature of consciousness.

[1233] I'm hopeful that they will.

[1234] They have been used around certain, I don't even know if features is the right term, but things that are called consciousness.

[1235] So consciousness can refer to not only just phenomenal consciousness, which is like, you know, the source of the hard problem and what it is to be like Nagle's description.

[1236] But the sense of self, which can be sort of like the experiential self moment to moment, or it can be like the narrative self, the stringing together of story.

[1237] So those are things that I think can be.

[1238] And a little bit's been done with psychedelics regarding that.

[1239] But I think there's far more potential.

[1240] But so like one story that unfolded is that psychedelics acutely have an effects on the default mode network, a certain pattern of activation amongst a subset of brain areas that is associated with self -referential processing.

[1241] It seems to be more active, more communication between these areas, like the posterior cingulate cortex and the medial prefrontal.

[1242] Cortex, for example, being parts of this and others that are tied with sort of thinking about yourself, remembering yourself in the past, projecting yourself into the future.

[1243] And so that it's an interesting story emerged when it was found that when psilocybin is on board, you know, in the person's system, that there's a, there's less communication amongst these these areas.

[1244] So with resting state fMRA imaging, that there's, there's less synchronization or presumably communication between these areas.

[1245] And so I think it has been overstated into, ah, we see this is like this is the dissolving of the ego.

[1246] This is it, the story made a whole lot of sense.

[1247] But there's several, I think that story is really being challenged.

[1248] Like one, we see increasing number of drugs that are, that, that decouple that network, including ones like that aren't psychedelic.

[1249] So this may just be a property, frankly, of being, like, you know, screwed up, you know, like, you know, being out of your head, being like, like, you know.

[1250] Anytime you mess with a perception system, maybe it screws up some, some, just our ability to just function in the holistically like we do in order, yeah, for the brain to perceive stuff, to be able to map it to memory, to connect things together, the whole recurre mechanism, that could just be messed with.

[1251] Right.

[1252] And it couldn't, I'm speculating, it could be tied to more if you had to download into the language, everyday language, like, not feeling like yourself.

[1253] Like, so whether that be, like, really drunk or really hopped up on amphetamine or, you know, on, like, we found it, like, decoupling in the default mode network on Salvin Ornay, which is a smokeable psychedelic, which is a non -classic psychedelic, but another one where, like DMT, where people are often talking to entities and that type of thing, that was a really fun study to run.

[1254] But nonetheless, most people say it's not a classic psychedelic and doesn't have some of those phenomenal features that people report from classic psychedelics and not sort of the clear sort of ego loss type, at least not in the way that people report it with classic psychedelic.

[1255] So you get it with all these different drugs.

[1256] And then you also see just broad changes in network activity with other networks.

[1257] And so I think that story took off a little too soon.

[1258] Although, so I think in the story that the DMN, the default mode network, relating to the self, and I know some neuroscientists, it drives them crazy if you say it's the ego.

[1259] Yeah.

[1260] But self -referential processing, if you go that far, like, that was already known before psychedelics.

[1261] Psychedelics didn't really contribute to that, the idea that this type of brain network activity was related to a sense of self.

[1262] But it is absolutely striking that psychedelics that people report with pretty high reliability, these unity experiences that where people subjectively, like they report losing or, again, like the boundaries of that, however you want to say it, like these unity experiences, I think we can do a lot with that in terms of figuring out the nature of the sense of self.

[1263] Now, I don't think that's the same as the hard problem or the existence of phenomenal consciousness, because you can build an AI system, and you correct me if I'm wrong, that, like, will pass a Turing test in terms of demonstrating the qualities of, like, a sense of self.

[1264] It will talk as if there's a self, and there's probably a certain, like, algorithm or whatever, like computational, like, you know, scaling up of computations that results.

[1265] And somehow, and I think this is the argument with humans, with some have speculated this, why do we have this illusion of the self that's evolved?

[1266] And we might find this with AI that like it works, you know, having a sense of self or in that state it wrong incorrectly, like acting as if there is an agent at play and damage behaviorally acting like, you know, there is a there is a self that might kind of.

[1267] work.

[1268] And so you can program a computer or a robot to basically demonstrate, have an algorithm like that and demonstrate that type of behavior.

[1269] And I think that's completely silent on whether there's an actual experience inside there.

[1270] I've been struggling to find the right words and how I feel about that whole thing.

[1271] But because I've said it poorly before.

[1272] I've before said that there's no difference between the appearance and the actual existence of consciousness or intelligence or any of that.

[1273] What I really mean is the more the appearance starts to be, look like the thing, the more there's this area where it's like, I don't think, I don't, our whole idea of what is real and what is just an illusion is not the right way to think about it.

[1274] So the whole idea is like if you create a system that looks like it's having fun, the more it's realistically able to portray itself as having fun, like there's a certain gray area at which the system is having fun.

[1275] And same with intelligence, same with consciousness.

[1276] And we humans want to simplify, like it feels like the way we simplify the existence and the illusion of something is missing the whole truth of the nature of reality, which we're not yet able to understand.

[1277] Like it's the 1 % we only understand 1 % currently, so we don't have the right physics to talk about things.

[1278] We don't have the right science to talk about things.

[1279] But to me, like the faking it and actually it being done.

[1280] true is um the the difference is much smaller than when humans would like to imagine that's my intuition but philosophers hate that because and uh guess what it's philosophers what have you actually built uh so like to me is that's the difference in philosophy and engineering it feels like if we push the creation the engineering like fake it until you make it all the way which is like fake consciousness until you realize, holy crap, this thing is conscious, fake intelligence until you realize, holy crap, this is intelligence.

[1281] And from the, my curiosity with psychedelics and just neurobiology, neuroscience is like, it feels, I'm, I love the armchair.

[1282] I love sitting in that armchair because it feels like at a certain point you're going to think about this problem and there's going to be an aha moment.

[1283] Like, that's what the armchair does.

[1284] Sometimes science prevents you from really thinking, wait, like, it's really simple.

[1285] There's something really simple.

[1286] Like there's some, there could be some dance of chemicals that we're totally unaware of, not from aspects of like which chemicals to combine with which biological architectures, but more like we were thinking of it completely wrong.

[1287] that out of the blue maybe the human mind is just like a radio that tunes into some other medium where consciousness actually exists like those weird sort of hypothetically like maybe we're just thinking about the human mind totally wrong maybe there's no such thing as individual intelligence maybe it is all collective intelligence between humans like maybe the intelligence is possessed in the communication of language between minds and then in fact consciousness is a property of that language versus a property of the individual minds and somehow the neurotransmitters will be able to connect to that so then AI systems can join that common collective intelligence that common language you know like just thinking completely outside of the box I just said a much of crazy thing I don't know but but thinking outside the box and there's something about subtle manipulation of the chemicals of the brain, which feels like the best, or one of the great chances of the scientific process leading us to an actual understanding of the hard problem.

[1288] So I am very hopeful that, and so I, I mean, I'm a radical empiricist, which I'm very strong with that.

[1289] Like, that's what, you know, so, you know, science isn't about ultimately being a materialist.

[1290] It's like, it's about being an empiricist in my view.

[1291] And so, for example, I'm very fascinated by the so -called sci phenomenon, you know, like stuff that people just kind of reject out of hand.

[1292] You know, I kind of orient towards that stuff with an idea of, you know, hey, look, you know, what we consider, like anything exists as natural.

[1293] And so, but the boundary of what we observe in nature, like what we recognize as in nature moves, like what we do today and what we know today would only be described as magic 500 years ago or even 100 years ago, something.

[1294] of it.

[1295] So there will surely be things that, like you explain these phenomena that just sound like completely, they're supernatural now, where there may be for some of it, like some of it might turn out to be a complete bunk and some of it might turn out to be, it's just another layer of nature, whether we're talking about multiple dimensions that were invoked or something that we don't even have the language towards.

[1296] And what you're saying about the moving together of the model and the real thing of conscious, like, I'm very sympathetic to that.

[1297] So that's that part of like on the armchair side where I want to be clear I can't say this as a scientist but just terms of speculating.

[1298] I find myself attracted to these more of the sort of the pan -psychism ideas and that kind of makes sense to me. I don't know if that's what you meant there, but it seemed like related the sense that ultimately if you were completely modeling, like it's like if you completely modeling unless you dismiss like the the idea that there is a phenomenal consciousness which i think is hard given that we all i seem like i have one that's really all i i i know but if that's so compelling i can't just dismiss that like if you're if you if you take that as a given then the only way for the model and the and the real thing to merge is if there is something baked into the nature of reality you know sort of like in the history of like there's certain just like fundamental forces or fundamental like in that and that's been useful for us and sometimes we find out that that's pointing towards something else or sometimes it's still a seem like it's a fundamental and sometimes it's a placeholder for someone to figure out but there's something like this is just a given you know this is just you know and sometimes something like gravity seems like a very good placeholder and then there's something better that comes to replace it so so you know I kind of think about like consciousness and I didn't I kind of had this inclination before I knew there was a term for it um Rosalian monosom, the idea that, which is a form of, again, I'm not, I'm an armchair philosopher, not a very good one.

[1299] Broadly panpsychism, by the way, is the idea that sort of consciousness permeates all matter.

[1300] Or it's a fundamental part of physics of the universe kind of thing.

[1301] Right.

[1302] And there's a lot of different flavors of it, as you're alluding to.

[1303] And something that struck me as like consistent with some just, you know, inclinations of mind, just total speculation is this idea of um everything we know of in science and and with most of the stuff we think of physics you know really describes it's all interactions it's not the thing itself like there there there is something to the and this sounds very new agey which is why it's it's very difficult and i have a high bullshit like meter and everything but like an isness I mean, I think about like Huxley, Aldous Huxley with his mescaline experience and doors of procession, like there's an isness there in, you know, Alan Watson, like there is a nature of being, again, very new agey sounding, but maybe there is something to, and when we say consciousness, we think of like this human experience, but maybe that's just, that's so processed and so, that's so far, so derivative of this kind of basic thing that we wouldn't even recognize the basic thing.

[1304] but the basic thing might just be this is not about the interaction between particles this is what it is like to exist as a particle and maybe it's not even particles maybe it's like spacetime itself I mean again totally in the speculation and something out of space time so it's funny because we don't have this neither the science nor the proper language to talk about it all we have is kind of little intuitions about there might be something in that direction of the darkness to pursue.

[1305] In that sense, I find panpsychism interesting in that, like, it does feel like there's something fundamental here.

[1306] The consciousness is not just like, okay, so the flip side consciousness could be just a very basic and trivial symptom, like a little hack of nature that's useful for, like, survival of an organism.

[1307] It's not something fundamental.

[1308] It's just this very basic, boring chemical thing that somehow is convinced us humans because we're very human -centric, we're very self -centric, that this is somehow really important, but it's actually pretty obvious.

[1309] Or it could be something really fundamental to the nature of the universe.

[1310] So both of those are, to me, pretty compelling.

[1311] And I think eventually scientifically testable, it is so frustrating that it's hard to design a scientific experiment currently.

[1312] But I think that's how Nobel Prizes are won, is nobody did it until they do it.

[1313] The reason I lean towards, and again, armchair spec, if I had to bet like $1 ,000 on which one of these ultimately be proved, I would lean towards, I'd put my bets on something like panpsychism rather than the emergence of phenomenal consciousness through complexity or computational complexity, because.

[1314] Although certainly, if there is some underlying fundamental consciousness, it's clearly being processed in this way through computation in terms of resulting in our experience and the experience presumably of other animals.

[1315] But the reason I would blend on panpsychism is to me, Occam's razor, it just, in terms of truly the hard problem, like at some point you have an inside looking out.

[1316] And even looking refers to vision and it doesn't, that's just an exact, you know, but just there's an inside experience something.

[1317] At some point of complexity, all of a sudden, you know, you start from this objective universe and all we know about is interactions between things and things happen.

[1318] And at this certain level of complexity, magically there's an inside.

[1319] That to me doesn't pass Occam's razor as easily as maybe there is a fundamental problem.

[1320] property of the universe of you know there's both subjective and objective there is both interactions amongst things and there is the thing itself yes but but yeah so i i'm of two minds i agree with you totally and half my mind and the other half is i've seen looking at cellular automata a lot which is complete it sure does seem that we don't understand anything about complexity like the emergence the just the property in fact that could be a fundamental property of reality is something within the emergence from simple things interacting somehow miraculous things happen and like that I don't understand that that could be that could be fundamental that like something about the layers of abstraction like layers of reality like really small things interacting and then on another layer emerges actual complicated behavior, even though the underlying thing is super simple.

[1321] Like that process, we don't really don't understand either.

[1322] And that could be bigger than any of the things we're talking about.

[1323] That's the basic force behind everything that's happening in the universe is from simple things, complex phenomena can happen.

[1324] And the thing that gives me pause is that I'm concerned about a threshold there like how is it likely that now there may be and there may be some qualitative shift that in the realm of like we don't even we don't even understand complexity yet like you're saying like so maybe there is but i do think like if it if it is a result of the complexity well you know just having helium versus hydrogen is a form of complexity having the existence of stars versus clouds of gas as a complexity the the entire universe has been this increasing complexity and so that kind of brings me back to then the other of like okay if there's if it's about complexity then we should then it exists at a certain level in these simple systems like a star or a you know they all have a complex atom psychism that's right but we humans uh the qualitative shift we might have evolved to appreciate certain kinds of thresholds right yeah i do think it's likely that this idea that whether or not there's an inner experience which is phenomenal it's the hard problem that acting like an agent like having an algorithm that basically like operates as if there is an agent that's clearly a thing that i think has worked and that there is a whole lot to figure out there that that and i think psychedelics will be extremely helpful in figuring more out about that because they do seem to a lot of times eliminate that or whatever, radically shift that sense of self.

[1325] Let me ask the craziest question.

[1326] Indulge me for a second.

[1327] This is a joke.

[1328] Weird of what we've been talking about?

[1329] Like, okay.

[1330] I got to get a seatbelt on.

[1331] All of this is a science.

[1332] All of that, despite the caveats about armchair, I think, is within the reach of science.

[1333] Let me ask one that's kind of also within the racial science, but as Joe likes to say, it's entirely possible, right?

[1334] Is it possible that with these DMT trips, when you meet entities, is it possible that these entities are extraterrestrial life forms?

[1335] Like our understanding of little green men with aliens that show up is totally off.

[1336] I often think about this.

[1337] Like, what would actual extraterrestrial intelligence look like.

[1338] And my sense is it will look like very different from anything we can even begin to comprehend.

[1339] And how would it communicate?

[1340] And how would it communicate?

[1341] Would it be necessarily spaceships with solar travel or?

[1342] Could it be communicating it through chemicals, through if there's the panpsychism situation?

[1343] If there's something, not if.

[1344] I almost for sure know we don't understand a lot about the function of our mind in connection to the fabric of the physics in the universe.

[1345] A lot of people seem to think we have theoretical physics pretty figured out.

[1346] I have my doubts because I'm pretty sure it always feels like we have everything figured out until we don't.

[1347] I mean, there's no grand unifying theory yet, right?

[1348] I mean, that's been widely recognized.

[1349] We could be missing out, like, the concept of the universe just can be completely off.

[1350] Like, how many other universes are there, all those, all those kinds of things.

[1351] I mean, just the basic nature of information, the time, time, all of those things.

[1352] Well, yeah, whether that's just like a thing we assign value to or whether it's fundamental or not, that's whole, I could talk to Shankar forever about whether time is emergent or fundamental to the reality.

[1353] But is it possible that the entities we meet are actual alien life forms?

[1354] do you ever think about that yeah yeah yeah yeah I do and and I've to some degree laid my cards out with by identifying as a radical empiricist you know it's like so the answer is it possible and I think you know ultimately if like if you're a good scientist you got to say now that's at the extremes it's a like yes yes you know and it might get more interesting when you had to you're asked to guess about the probability of that is that a one in a one in a million one in a trillion, one in a big, one in, uh, more than the number of atoms in the universe, uh, probability.

[1355] And as an empiric, is like, what, what is a good testable?

[1356] Like, how would you know the answer to that question?

[1357] Well, how would you be able to validate?

[1358] I mean, well, can you get some information that's verifiable?

[1359] Like, like, um, information that about some other planet that, that, that, or, or some aspect, some, some, and gosh, it would be an interesting range.

[1360] But what, like, um, information that, but what, range of discovery that we can anticipate we're going to know within um you know whatever a few years next five 10 20 years um and seeing if you can get that predict that information now and then over time it might be verified you know the type of thing like you know part of einstein's work was ultimately verified not until decades and decades later at least certain aspects through the um to empirical observations um but it but it's also possible that the alien beings have a very different value system and perception of the world where all of this little capitalistic improvements that we're all after like predicting the concept of predicting the future too is like totally useless to to other life forms that have that perhaps think in a much different way maybe a more transcendent way i don't know but so they wouldn't even sign the consent form to be a participant in our experiment.

[1361] They would not.

[1362] That would not.

[1363] And they wouldn't even understand the nature of these experiments.

[1364] I mean, that maybe it's purely in the realm of the consciousness thing that we talked about.

[1365] So communicating in a way that is totally different than the kinds of communication that we think of as on Earth.

[1366] Like, what's the purpose of communication for us?

[1367] for us humans the purpose of communication is sharing ideas it feels like like converging like it's the Dawkins like memes it's like we're sharing ideas in order to figure out how to collaborate together to get food into our systems and procreate and then like murder everybody in the neighboring tribe because they they'll steal our food like we are all about sharing ideas maybe it's possible to have another alien life form that's more about sharing experiences you know like it's less about ideas I don't know and maybe that'll be us in a few years like how could it not like instead of explaining something laboriously to you like having people to describe the ineffable psychedelic experience like if we could record that and then get the neural link of 50 years from now like oh just plug this into your just transferring the experiences it's like oh now you feel what it's what it's like and like in one sense like how could we not go there and then you get into the realm especially when you throw time into it are the aliens us yeah in the future or even like a transcendental temporal like the us beyond time like i don't know like you get into this realm there's a lot of possibilities yeah but i think you know there's one psychedelic researcher that's who did high -dose DMT um research in the 90s who speculated that um that and there was a lot of alien encounter experiences like maybe these are like entities from some other dimension or he labeled it as speculation but you know do you remember the name oh rick strassman who did yeah yeah the the DMT work he labeled it as speculation but you know i think that yeah i think we'd be wise to kind of you know it's always that balance between being empirically grounded and skeptical but also not being and i think in science often we are too closed.

[1368] Yeah.

[1369] Which relates to like you're talking about Elon, like in academia, it's like often, like, I think you're punished for thinking or even talking about 20 years from now because it's just so far removed from your next grant or for your next paper that you're, it's easy pickings.

[1370] And, you know, that you're not allowed to speculate.

[1371] So I think the, I'm a huge fan of, I think the best way, to me at least, to practice, like, science or to practice good engineering.

[1372] is to like do two things and just bounce off, like spend most of the time doing the rigor of the day -to -day of what can be accomplished now in the engineering space or in the science, like what can actually, what can you construct an experiment around do like that, the usual rigor of the scientific process.

[1373] But then every once in a while on a regular basis, to step outside and talk about aliens in consciousness.

[1374] And we just walk along, line of things that are outside the reach of science currently, free will, the illusion or the perception of the experience of free will, anything, just the entirety of it, being able to travel in time through warm holes, it's like it's really useful to do that, especially as a scientist.

[1375] Like if that's all you do, you go into a land where you're not actually able to think rigorously.

[1376] something, at least to me, that if you just hop back and forth, you're able to, I think, do exactly the kind of injection of out -of -the -box thinking to your regular day -to -day science that will ultimately lead to breakthroughs.

[1377] But you have to be the good scientists most of the time.

[1378] And that's consistent with what I think the great scientists of history.

[1379] Like in most of the history, you know, the greats, you know, the Newtons and, you know, Einstein's, I mean, they were, there was less of it.

[1380] And this change, I think, as time marched on, but less of a separation between those realms.

[1381] It's like there's the inclination now for it's like as a scientist.

[1382] And this is like, this is science, this is my work.

[1383] And then this is like my inclination is say, oh, Lex, don't take me too seriously because this is my armchair.

[1384] I'm not speaking as a scientist.

[1385] I'm bending over backwards to say, you know, to divide that self.

[1386] And maybe there's been less of, there's been that evolution.

[1387] And that's, and like the greats, like, didn't see that.

[1388] I mean, Newton, and you go back in time.

[1389] And it's like, that obviously, like, connects to it than religion, especially if that is the predominant world where Newton, like, how much, you know, like, how much time did he spend trying to, like, decode the Bible and whatnot, you know, and maybe that was a dead end.

[1390] But it's like, if, if you really believe in that, in that particular religion, and you're this mastermind and you're trying to figure things out.

[1391] It's not like, oh, this is what my job description is and this is what the grant wants.

[1392] It's like, no, I've got this limited time on the planet.

[1393] I'm going to figure out as much stuff as possible.

[1394] Nothing is off the table and you're just putting it all together.

[1395] So this is kind of this trajectory is really related to this siloing in science.

[1396] Like, again, related to my like, oh, I'm not a philosopher, you know, whether you can sit out of science or not empirical science, but like going to these different disciplines, like, you know, the greats, you know, didn't observe the boundaries didn't exist and they didn't observe them.

[1397] So speaking of the finiteness of our existence in this world, so on the front of psychedelics and teaching you lessons as a research as a human being, what have you learned about death, about mortality, about the finiteness?

[1398] of our existence.

[1399] Are you yourself afraid of death?

[1400] And how has your view, do you ponder it?

[1401] And has your view of your mortality changed with the research you've done?

[1402] Yeah.

[1403] Yeah.

[1404] So I do ponder it.

[1405] Are you afraid of death?

[1406] Probably on a daily basis, I ponder it.

[1407] I would, I'd have to pick it apart more and say, yeah, I am afraid of dying, like the process of dying.

[1408] I'm not afraid of being dead.

[1409] I mean, I'm not afraid of, I think it was Penn Gillette that said, and he may have gotten it from someone else, but like, I'm not afraid of the year, you know, 1862 before I existed.

[1410] I'm not afraid of the year 22, 62 after I'm gone.

[1411] Like, it's going to be fine.

[1412] But yeah, you know, dying.

[1413] Like, I'd be lying if I said I wasn't afraid of, you know, dying.

[1414] And so there's both like the process of dying, like, yeah, it's usually not good.

[1415] It'd be nice if it was after many, many years and just sort of, you know, I'd rather not fall, you know, die in my sleep.

[1416] I'd rather kind of be conscious, but sort of just fade out with old age maybe.

[1417] But, but like, you know, just being in an accident and like, you know, horrible diseases, I've seen enough loved ones.

[1418] It's like, yeah, this is not good.

[1419] This is enough to be, you know, I'd like to say that I'm peaceful and sort of balanced enough that I'm not concerned about.

[1420] But no, like, yeah, I'm afraid of dying.

[1421] but I'm also concerned about I think about family I'm really I'm afraid or at least concerned about like not being there like with a three year old not being there not being there for him and my wife and my mom the rest of her life I'm concerned about not I'm concerned more about like the harm that it would cause if I left prematurely and then kind of even bigger along the lines of some of the stuff that forward thinking we've been talking about, I think maybe way too much about just like, and I'll never know the answer.

[1422] So even if I lived to, you know, 120, like, but, like, I want to know as much as I can, but, like, how is this going to work out, like, as humans?

[1423] Are we, and a big one I think is, are we going to, and I don't think, unfortunately, I'm going to learn it in my lifetime, even if I lived to a ripe old age, but, well, I don't know.

[1424] Is this going to work out?

[1425] Like, are we going to escape the planet?

[1426] I think that's one of the, biggies like are we going to like the survival of the speed like I think the next like the time we're in now it's like with the nuclear weapons with pandemics and with um uh I mean we're going to get to the point where anyone can can build a hydrogen bomb like you know it's like you just like the or engineer like the you know something that's a million times worse than COVID and then just spread it's like yeah we're getting to this period of and then I you know not to mention climate change you know it's like although I think that's not there's probably going to be surviving with that regard, you know, but it could be really bad.

[1427] But these existential threats, I think the only real guarantee that we're going to get another, you name it, thousand, million, whatever years is like diversity, diversify our portfolio, get off the planet, you know, don't leave this one.

[1428] Hopefully we keep, you know, but like, and I, you know, it's like either we're going to get snuffed out, like, really quickly, or we're going to, Like, if we, if we reach that point, and it's going to be over the next, like, 100, 200 years.

[1429] Like, we're probably going to survive, like, until, like, I mean, you know, like our sun, like, and even beyond that, like, like, we're probably going to be talking about millions and millions of years.

[1430] It's like, and we're, we're, I don't know, in terms of the planet, four billion years into this.

[1431] And depending on how you count our species, you know, we're, you know, we're millions of years into this.

[1432] And it's like, it's, this is like the point of the relay race where we can really.

[1433] screw up.

[1434] So that would make you feel pretty good when you're on your deathbed at 120 years old and there's something hopeful about there's a colony starting up on Mars and it's like...

[1435] Yeah, Titan, like whatever, you know, like, yeah, like that we have these colonies out there that would tell me like, yeah, then at least we'd be good until like the, you know, hopefully probably until the sun goes red giant, you know what I mean?

[1436] Rather than, oh, like 20 years from now when there's some someone with their finger on the nuclear button that just you know misperceives a you know the radar you know like the signal they they think Russia's attacking they're really not or China and like that's probably how a nuclear accident war is going to start rather than you know or the like I said these other horrible things does it not make you sad that you won't be there if we are successful of proliferating throughout the observable universe that you won't be there to experience any of it?

[1437] Just the ego death, right?

[1438] It's the death because you're still going to die and it's still going to be over.

[1439] That's, you know, Ernest Becker and those folks really emphasize the terror of death that if we're honest, we'll discover if we search within ourselves, which is like, this thing is going to be over.

[1440] most of our existence is based on the illusion that is going to go forever and when you sort of realize it's actually going to be over like today like I might murder you at the end of this conversation it might be over today or like you on going home this might be your last day on this earth and it's I mean like pondering that And I suppose, I suppose one thing to be, I, I, I, if I were to push back, it's interesting, is you actually, I think you see comfort in the sadness of how unfortunate it would be for your family to not have you.

[1441] Because the really, even, even the deeper, yes, but that's the simple fear.

[1442] Even the deeper terror is like, like, this, this thing doesn't.

[1443] last forever.

[1444] Like, I think, I don't know, they're, like, it's hard to put the right words to it, but it feels like that's not truly acknowledged by us, by each of, each of us.

[1445] Yeah.

[1446] I think this is the, I mean, getting back to the psychedelics in terms of the people in our work with cancer patients who, we had psilocybin sessions to help them, and it did substantially help them.

[1447] The vast majority, in terms of dealing with these existential issues.

[1448] And I think, you know, it's something we, I could say that I really feel that I've come along in that both like being with folks who have died that are close to me and then also that work, I think are the two biggies and sort of like, you know, I think I've come along in that, that sort of acceptance of this, like, it's not going to last.

[1449] Any, whether we're at the personal level or even at the species levels, like at some point, all the stars are going to fade out and it's going to be the realm, of black which is going to be the vast majority if it can unless there's a big crunch which apparently doesn't seem likely like most of the universe there's this blink of an eye that's happening right now that life is even possible like the era of stars so it's like we're going to fade out at some point like you know and you know then we get at this level of consciousness and like okay maybe there is life after death maybe there's maybe times an illusion maybe we're like that part I'm ready for like I'm like you know like that that would be really great and I'm looking for I'm afraid of that at all.

[1450] It's like even if it's just strange, like if I could push a button to enter that door, I mean, I'm not going to, you know, die, you're not going to kill myself, but it's like if I could take a peek of what that reality is or choose, at the end of my life, if I could choose of entering into a universe where there is an afterlife of something completely unknown versus one where there's none, I think I'd say, well, let's see what's behind that.

[1451] That's a true scientist's way of thinking.

[1452] If there's a door, you're excited about opening it and going in.

[1453] Right.

[1454] But I am attracted to this idea like like you know it's and i recognize it's easier said than done to say i'm okay with not existing yeah it's like the real test is like okay check me on my deathbed you know it's like it's a oh oh so i'd be all right did it's beautiful thing and the humility of surrendering and i really hope and i think i'd probably be more likely to be in that realm right now than i would like if you or check me when i get a terminal cancer diagnosis and i really hope i'm more in that realm but i i i know enough about human nature to know that like I don't want to I can't really speak to that because I haven't been in that situation and I think there can be a beauty to that and the transcendence of like yeah and you know it was it was beautiful not just despite all that but because of that because ultimately there's going to be nothing and because we came from nothing and we dealt with all this shit the fact that there was still beauty and truth and connection like that you know like it just it's a beautiful thing but i i hope i'm in that it's easy to say that now like yeah do you think there's a meaning to this thing we got going on uh life existence on earth to us individuals from a psychedelic researcher perspective or from just a human perspective those those merged together for me like because it's it's just hard i've been doing this research for almost 17 years and like not just the cancer study but so many times people like I remember a session in this in one of our studies that someone who wasn't getting any treatment for anything but one of our healthy normal studies where he was contemplating the the suicide of his son and just these I mean just like the most intense human experiences that you can have in the most vulnerable situations sometimes like people like you know and it's just like you have that have a and you just feel lucky to be part of that process that people trust you to let their guards down like that um like I don't know the meaning I think the meaning of life is is defined meaning and I think I actually I think I just described it a minute ago it's like that transcendence of everything like the it's the beauty despite the absolute ugliness it's the it's the and as a species and i think more about this like i think about this a lot it's the fact that we are i mean we're we come from filth i mean we're we're you know we're animals we come from like we're all descendant from murderers and rapists like we despite that background we are capable of this the self -sacrifice and and the connection and figuring things out, you know, truth, science and other forms of truth, you know, seeking, and an artwork, just the beauty of music and other forms of art. It's like the fact that that's possible is the meaning of life.

[1455] I mean...

[1456] And ultimately, that feels to be creating more and richer experiences.

[1457] the, from a Russian perspective, both the dark, you mentioned the cancer diagnosis or losing a child to suicide or all those dark things is still rich experiences.

[1458] And also the beautiful creations, the art, the music, the science, that's also a rich experience.

[1459] So somehow we're figuring out from just like psychedelics expand our mind to the possibility of experiences, that somehow we're able to figure out different ways of society to expand the realm of experiences.

[1460] And from that would gain meaning somehow.

[1461] Right.

[1462] And that's part of like this, we're going across different levels here.

[1463] But like the idea that so -called bad trips or challenging experiences are so common in psychedelic experiences, it's like that's a part of that.

[1464] Like, yeah, it's tough.

[1465] And most of the important things in life are really, really tough and scary.

[1466] And most of the things like the death of a loved one, like it told, like the, the, like the, greatest learning experiences and things that make you who you are are the horrors and you know it's like yeah we try to minimize them we try to avoid them but and i don't know i think we all need to get into the mode of like giving ourselves a break both personally and societally i mean i went through like the i think a lot of people do these days in my 20s like oh the humans are just kind of a disease on the planet and like and then in terms of our country in terms of the united states it's like oh we have all these horrible you know sins in our past and it's like i think about that like the i think about it like my my three -year -old it's like yeah you can construct a story where this is all just horrible you can look at that stuff and say this is all just horror you know where you are is like there's no logical answer to our you know rational answer to say we're not a disease on the planet from one lens we are you know you know and like there's you could just look at humanity is that like nothing but this horrible thing you can look at any you and you name the system you know oh you know modern medicine western medicine you know the university system and it's like you can dismiss everything so you know big farm like hopefully these vaccines work and then like yeah i'd like to you know like i'm kind of glad big pharma was a part of that like you know and it's like the united states you can like point to the horrors like any other country that's been around a long time that has these legitimate horrors and kind of dismiss like These beautiful things, like, yeah, we have this, like, modifiable constitutional republic that just, like, I still think is the best thing going, you know, that as a model system of, like, how humans have to figure out how to work together.

[1467] It's like it's how there's no better system that I've come across.

[1468] Yeah, there's, if we're willing to look for it, there's a beautiful court to a lot of things we've created.

[1469] Yeah, this country is a great example.

[1470] of that, but most of the human experience has a beauty to it, even the suffering.

[1471] Right.

[1472] So the meaning is choosing to focus on that positivity and not forget it.

[1473] Beautifully put.

[1474] Speaking of experiences, this was one of my favorite experience in this podcast talking to you today, Matthew.

[1475] I hope we get a chance to talk again.

[1476] I hope to see you on Joe Rogan.

[1477] It's a huge honor to talk to you.

[1478] Can't wait to read your papers.

[1479] Thanks for talking today.

[1480] Likewise, I very much enjoyed it.

[1481] Thank you.

[1482] Thanks for listening to this conversation with Matthew Johnson, and thank you to our sponsors.

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[1488] If you enjoy this thing, subscribe on YouTube, review it with five stars on Apple Podcast, follow on Spotify, support on Patreon, or connect with me on Twitter at Lex Friedman.

[1489] And now let me leave you with some words from Terrence McKenna.

[1490] Nature loves courage.

[1491] You make the commitment, and nature will respond to that commitment by removing impossible obstacles.

[1492] Dream the impossible dream.

[1493] And the world will not grind you under.

[1494] It will lift you up.

[1495] This is the trick.

[1496] what all these teachers and philosophers who really counted, who really touched the alchemical gold, this is what they understood.

[1497] This is the shamanic dance in the waterfall.

[1498] This is how magic is done by hurling yourself into the abyss and discovering it's a feather bed.

[1499] Thank you for listening and hope to see you next time.